Association of ApoE genotype with clinical features and outcome in idiopathic normal pressure hydrocephalus (iNPH): a preliminary report

Abstract

Fifteen patients suspected of having iNPH were clinically evaluated and their ApoE genotype determined prior to a possible ventriculoperitoneal shunt insertion. All patients fulfilling our criteria for intervention and who had a shunt implanted with good results were homozygous for the ApoE3/3 genotype.

APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus

“…Furthermore, APOE genotypes did not predict shunt response in our 121 shunted iNPH patients. Instead, in a series of 15 iNPH patients evaluated by gait analysis before and after CSF drainage, the APOE ɛ3/ɛ3 genotype seemed to predict improved gait 30. It should be noted that the cited study bears significant weaknesses, including a very small number of patients and no detection of primary or comorbid AD patients by means of brain biopsy, potentially invalidating the shunt response.…”

“…To date, the APOE4 allele is the most important independent genetic risk factor for late onset AD25–27 (http://www.alzgene.org). APOE4 is also associated with other neurological disorders,16 28 including iNPH 29 30. To date, the possible association of APOE and NPH has been explored in only two small cohorts.…”

A Segmental Copy Number Loss of the SFMBT1 Gene Is a Genetic Risk for Shunt-Responsive, Idiopathic Normal Pressure Hydrocephalus (iNPH): A Case-Control Study

“…The increased allele frequency of apolipoprotein E epsilon4 (ApoE4) was reported to be a possible genetic risk for iNPH in a small number of iNPH samples (n = 13) [17]. Later, in another study (n = 15), the ApoE3/3 genotype was shown to be more frequently observed in shunt-responsive iNPH patients as compared with other genotypes [18]. However, in a recent study using more samples of iNPH, ApoE genotypes have been shown to distribute similarly in shunt-responsive (n = 94) and non-responsive (n = 16) iNPH patients and healthy controls [19].…”

Cerebrospinal fluid biomarkers and genetic factors associated with normal pressure hydrocephalus and Alzheimer’s disease: a narrative review

“…APOE4 allele is the most significant independent genetic risk factor for late-onset AD [88][89][90] APOE4 is also correlated with other neurological diseases [91,92]. Studies showed that homozygous ApoE3/3 genotype was slightly associated with gait improvement in patients with iNPH but there was no other evidence for the correlation of APOE4 genotype, iNPH disease, and response to shunt [93][94][95].…”