Association of Apgar score at five minutes with long-term neurologic disability and cognitive function in a prevalence study of Danish conscripts

Ehrenstein, Véra; Pedersen, Lars; Grijota, Miriam; Nielsen, Gunnar Lauge; Rothman, Kenneth J.; Sørensen, Henrik Toft

doi:10.1186/1471-2393-9-14

Cited by 141 publications

(135 citation statements)

References 36 publications

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“…18,19 In term deliveries, low Apgar score at 5 and 10 minutes frequently reflects perinatal asphyxia and acidosis, and predicts neonatal morbidity and mortality. [20][21][22] Here, as in previous studies, 10, 23 both postterm and earlyterm birth led to increased risk for low Apgar score, known to associate with long-term neurologic disability, decreased cognitive function, 24 epilepsy, 25 and CP. 21 In our study, the strongest risk factor for neurologic morbidity was low Apgar score at 1 minute, possibly explained by limitations in recording Apgar score at 5 minutes in the MBR.…”

Section: Figuresupporting

confidence: 60%

Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth

Seikku¹,

Gissler

Andersson

et al. 2016

Pediatrics

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Section: Figuresupporting

confidence: 60%

Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth

Seikku¹,

Gissler

Andersson

et al. 2016

Pediatrics

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“…5min after birth for the Apgar score), they have a high specificity and NPV; the converse is true when they are assessed at a later time (e.g. 10min or more after birth for the Apgar score), [2][3][4][5] as shown in Table II. A combination of clinical variables is more predictive of subsequent outcome than individual analyses; for example, Apgar scores of 0 to 3, measured 5 minutes after birth, have greater prognostic value when combined with clinical presentations of peripartum complications, fetal acidaemia, and signs of neonatal encephalopathy.…”

Section: Prognostic Indicators Response To Resuscitationmentioning

confidence: 99%

Early predictors of outcome in infants treated with hypothermia for hypoxic–ischaemic encephalopathy

Merchant

Azzopardi

2015

Develop Med Child Neuro

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Hypoxic–ischaemic encephalopathy (HIE) is a leading cause of acquired neonatal brain injury. Assessment of the severity of cerebral injury and likely neurological outcome in infants with HIE is important for determining management and prognosis, for counselling parents, and for selection for neuroprotective trials. The condition of the infant at birth, the severity of HIE, neurophysiological tests, including amplitude‐integrated electroencephalography (aEEG), biochemical markers, and neuroimaging have been used to assess prognosis and predict long‐term outcome. The predictive accuracy of these indicators in the early postnatal period is modest. Neurophysiological assessment seems to be most helpful during the first 24 to 48 hours after birth whilst magnetic resonance imaging (MRI) seems most informative later. Several biochemical markers, including serum S100β and neuron‐specific enolase (NSE), are also associated with HIE but their levels depend on the timing of sampling and their prognostic value is uncertain. Comprehensive neurophysiological assessment and neuroimaging may be limited to specialist centres. Therapeutic hypothermia is now standard care in infants with moderate to severe HIE so it is important to examine the influence of hypothermia on the assessment of prognosis in these infants.

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“…Se ha descripto la asociación entre puntaje de Apgar y trastornos del neurodesarrollo, 23 y también entre un bajo puntaje Apgar y déficit atencional e hiperactividad en niños de edad escolar. 24 Aunque la puntuación de Apgar menor a 7 es un índice fiable de la condición del recién nacido inmediatamente después del nacimiento, la asociación entre baja puntuación Apgar y discapacidad neurológica no predice qué alteraciones neurológicas pueden ocurrir a largo plazo.…”

Section: Factores Pre Y Perinatalesunclassified

Riesgo neurológico en el niño de mediano riesgo neonatal

Vericat

Orden

2017

Acta Pediatr Mex

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255www.actapediatrica.org.mx Artículo de revisión Acta Pediatr Mex. 2017 jul;38(4):255-266. Riesgo neurológico en el niño de mediano riesgo neonatalResumen INTRODUCCIÓN: los neonatos de mediano riesgo suelen presentar alteraciones del neurodesarrollo, sutiles o inaparentes, que pueden evidenciarse a mediano y a largo plazos; es por ello que se les considera niños de riesgo neurológico. La identificación de los factores de riesgo asociados con los problemas del neurodesarrollo es un primer paso para prevenir o reducir sus efectos.OBJETIVO: con esta revisión cualitativa de la literatura especializada pretendemos describir las características de un grupo de neonatos denominados colectivamente recién nacidos de mediano riesgo neonatal y que, al nacer, no presentan compromiso evidente del desarrollo neurológico. Indagamos, también sobre los factores etiológicos asociados con esta condición. MATERIALES Y MÉTODOS:realizamos una búsqueda bibliográfica en las bases Scientific Electronic Library Online (SciELO), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS), la Biblioteca Nacional de Medicina de Estados Unidos de Norte América (NLM-Medline) y la Red de Revistas Científicas de América Latina y el Caribe, España y Portugal (RedALyC) centrada en factores de riesgo neurológico.RESULTADOS: el incremento de los controles prenatales, la reducción de los nacimientos pretérmino y del parto por cesárea son factores relevantes para el óptimo neurodesarrollo. Luego del parto es necesario extremar los cuidados del neonato en las Unidades de Cuidado Intensivo Neonatal controlando cuadros tales como la hiperbilirrubinemia, la sepsis neonatal y la dificultad respiratoria, asociados con alteraciones del desarrollo en los neonatos de mediano riesgo.CONCLUSIONES: las intervenciones para evitar o reducir el riesgo neurológico en los neonatos de mediano riesgo deben establecerse desde el inicio de la gestación y continuar durante toda la permanencia en las Unidades de Cuidado Intensivo Neonatal.PALABRAS CLAVE: recién nacido, trastornos del neurodesarrollo, factores de riesgo, neonatología, desarrollo infantil. OBJECTIVE:To describe the characteristics of a group of newborns collectively referred to as moderate-risk neonates, who at birth do not show neurodevelopmental disorders, and to investigate the etiological factors associated with this condition. METHODS:We carried a bibliographic search was performed in the SciELO, LILACS, Medline and RedALyC databases focused on neurological risk factors. RESULTS:Increased prenatal control and the reduction of preterm and cesarean delivery are important factors for optimal neurodevelopment. After delivery, newborn care in NICUs is critical, by controlling pathologies such as hyperbilirubinemia, neonatal sepsis, and respiratory distress associated with developmental abnormalities in MRN. CONCLUSIONS:Interventions to avoid or reduce neurological risk in MRN must be established from the beginning of pregnancy and continued during the NICU stay.

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Association of Apgar score at five minutes with long-term neurologic disability and cognitive function in a prevalence study of Danish conscripts

Cited by 141 publications

References 36 publications

Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth

Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth

Early predictors of outcome in infants treated with hypothermia for hypoxic–ischaemic encephalopathy

Riesgo neurológico en el niño de mediano riesgo neonatal

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