Association of apelin and AF in patients with implanted loop recorders undergoing catheter ablation

Uher, Tomáš; Böhm, Allan; Urban, L.; Tóthová, Ľubomíra; Bachárová, Ljuba; Musil, Peter; Kyselovič, Ján; Michalek, Peter; Vachalcová, Marianna; Olejník, Peter; Hatala, Róbert

doi:10.4149/bll_2020_079

Cited by 4 publications

(12 citation statements)

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“…Our previous research confirmed that apelin has high sensitivity and specificity to predict and quantify AF in patients with minimal cardiovascular comorbidities and low risk of stroke ( 27 , 28 ). However, this result is not sufficient for use in clinical practice where there would be more complex cases and it would not be known whether apelin would be able to provide sufficient diagnostic power in patients with multiple comorbidities who are at high risk of stroke.…”

Section: Discussionsupporting

confidence: 80%

“…In our previous research that included only patients with low risk of stroke, we showed that apelin is significantly decreased in patients with AF compared to patients without AF (27,28). Whether this result also applies to patients with cardiovascular comorbidities and high risk of stroke is unknown.…”

Section: Introductionmentioning

confidence: 86%

“…Our knowledge of AF pathogenesis has evolved and emerging evidence strongly links AF with inflammation, oxidative stress and atrial fibrosis (15)(16)(17)(18)(19)(20). Several plasmatic biomarkers for AF have been studied (21)(22)(23)(24)(25) and apelin, an endogenous regulatory peptide associated with many physiological and pathophysiological processes (26), has shown promising results (27)(28)(29). Among other effects on cardiovascular system, apelin shortens action potential duration in atrial myocytes via its effects on multiple ionic channels.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke

Böhm

Snopek

Tóthová

et al. 2021

Front. Cardiovasc. Med.

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Background: Atrial fibrillation (AF) is associated with high risk of stroke preventable by timely initiation of anticoagulation. Currently available screening tools based on ECG are not optimal due to inconvenience and high costs. Aim of this study was to study the diagnostic value of apelin for AF in patients with high risk of stroke.Methods: We designed a multicenter, matched-cohort study. The population consisted of three study groups: a healthy control group (34 patients) and two matched groups of 60 patients with high risk of stroke (AF and non-AF group). Apelin levels were examined from peripheral blood.Results: Apelin was significantly lower in AF group compared to non-AF group (0.694 ± 0.148 vs. 0.975 ± 0.458 ng/ml, p = 0.001) and control group (0.982 ± 0.060 ng/ml, p < 0.001), respectively. Receiver operating characteristic (ROC) analysis of apelin as a predictor of AF scored area under the curve (AUC) of 0.658. Apelin's concentration of 0.969 [ng/ml] had sensitivity = 0.966 and specificity = 0.467. Logistic regression based on manual feature selection showed that only apelin and NT-proBNP were independent predictors of AF. Logistic regression based on selection from bivariate analysis showed that only apelin was an independent predictor of AF. A logistic regression model using repeated stratified K-Fold cross-validation strategy scored an AUC of 0.725 ± 0.131.Conclusions: Our results suggest that apelin might be used to rule out AF in patients with high risk of stroke.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke

Böhm

Snopek

Tóthová

et al. 2021

Front. Cardiovasc. Med.

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“…This research follows and builds on previous fi ndings from our small pilot study, with the goal to better clarify the role of apelin in the management of AF patients (14). To our knowledge this is the fi rst study related to apelin and AF taking an advantage of data acquired from the patients with implantable loop-recorders and long-term follow-up.…”

Section: Discussionmentioning

confidence: 86%

“…One of the problems with studying and analysing the outcomes of PVI for AF is dichotomizing the patients into those responding and not responding to the therapy. Previous studies and our own experience showed several diffi culties in accurately identifying these patients (14,34). Using a continuous variable of AF burden, as used in this study, instead of dichotomous division to responders and non-responders offers a better insight into this problem and allows a more precise analysis of the relationship between apelin and atrial fi brillation.…”

Section: Discussionmentioning

confidence: 99%

Concentration of apelin inversely correlates with atrial fibrillation burden

Böhm¹,

Urban²,

Tóthová³

et al. 2021

BLL

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AIM: Asymptomatic atrial fi brillation (AF) detection and pulmonary veins isolation (PVI) outcome prediction remain challenging. Our aim was to study the association between apelin and paroxysmal AF in patients undergoing radiofrequency catheter PVI. METHODS: Sixty-three consecutive patients (55 ± 8years, 12 females) with paroxysmal AF without a structural heart disease and implanted ECG loop recorders undergoing PVI and healthy control group of 34 persons (41 ± 9.5years, 21 females) were included. Apelin plasmatic concentrations were measured before and three months after PVI. AF burden was continually assessed for three years. RESULTS: Apelin was signifi cantly decreased in AF patients compared to the healthy controls (0.79 ± 0.09 vs 0.98 ± 0.06 ng/ml; p < 0.00001). Apelin plasmatic concentration of 0.89 ng/ml had 94 % specifi city and 89 % sensitivity for AF prediction with the area under the curve (AUC) of 0.96. After propensity matching to sex, age and comorbidities, apelin concentration was signifi cantly lower in AF group (0.78 ± 0.1 vs 0.99 ± 0.06 ng/ml; p < 0.0001; AUC: 0.97). There was a signifi cant inverse correlation between apelin concentration and AF burden both before and after PVI (Rho =-0.22; p = 0.05) and (Rho =-0.51; p = 0.006), respecti vely. There was no signifi cant association between pre-PVI apelin and PVI long-term outcome. CONCLUSION: In patients without a structural heart disease apelin showed a signifi cant specifi city and sensitivity for AF prediction and inversely correlated with AF burden (Tab.

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Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers

Bachárová

Kollárová

Bezak

et al. 2023

IJMS

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Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the basic diagnosis detecting the increase in the LV size is the domain of imaging methods such as echocardiography and cardiac magnetic resonance. However, to evaluate the functional status indicating the gradual deterioration of the left ventricular myocardium, additional methods are available approaching the complex process of hypertrophic remodeling. The novel molecular and genetic biomarkers provide insights on the underlying processes, representing a potential basis for targeted therapy. This review summarizes the spectrum of the main biomarkers employed in the LVH valuation.

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Association of apelin and AF in patients with implanted loop recorders undergoing catheter ablation

Cited by 4 publications

References 0 publications

Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke

Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke

Concentration of apelin inversely correlates with atrial fibrillation burden

Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers

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