Association of anxiety level with polymorphic variants of serotonin transporter gene in Russians and Tuvinians

Reconstruction and Analysis of Gene Networks of Human Neurotransmitter Systems Reveal Genes with Contentious Manifestation for Anxiety, Depression, and Intellectual Disabilities

“…Many studies have shown a relationship between 5-HTTLPR polymorphism and anxiety [2], depression, and bipolar disorder, antidepressant sensitivity [28], risk of depression, and suicide [29]. However, in a recent study, it has been shown to reverse the effects of this polymorphism in several Asian populations such as Japanese [12], Chinese [30], and Tuvinians [11]. HLA-B (human leukocyte antigen) is one of the genes of the histocompatibility complex of class 1 in humans.…”

“…Genetic features indicate the likelihood of pathology, but this probability is modulated by many other factors, both increasing and reducing the risk of disease [10]. The search for the relationship between genetic and personal psychological characteristics in healthy people shows that such relationships are reliably detected in groups of people living in approximately the same socio-climatic conditions [11,12]. Associations between genetic and psychological characteristics identified in one of these groups may not be observed, or may even vary to the extent of inverse relationship, in other groups of people [11,13,14,15].…”

“…The search for the relationship between genetic and personal psychological characteristics in healthy people shows that such relationships are reliably detected in groups of people living in approximately the same socio-climatic conditions [11,12]. Associations between genetic and psychological characteristics identified in one of these groups may not be observed, or may even vary to the extent of inverse relationship, in other groups of people [11,13,14,15]. A similar situation is observed for the study of the relationship between neurophysiological (brain electrophysiological or hemodynamic activity), behavioral, and psychological characteristics of healthy people and clinical patients.…”

ICBrainDB: An Integrated Database for Finding Associations between Genetic Factors and EEG Markers of Depressive Disorders

“…In this connection, most of the open databases, including EEG, genotyping data, and psychological surveys, do not take into account the regional specifics of the survey participants. However, there are also studies [2,3], according to which the associations between genetic and neurophysiological factors on the one hand, and the risk of mental disorders and psychological personality traits, on the other hand, are significantly modulated by climatic and ethnographic characteristics of people. The novelty of our database is that it contains the results of a survey of people from four regions (Siberian industrial city, rural areas of Western Siberia, the Republic of Tuva, and the Republic of Yakutia), which differ greatly both in climate and ethnic composition of the population.…”