Association of antibody responses to microbial antigens and complications of small bowel Crohn’s disease

Mow, William; Vasiliauskas, Eric A.; Lin, Ying; Fleshner, Phillip; Papadakis, Konstantinos A.; Taylor, Kent D.; Landers, Carol J.; Abreu-Martin, Maria T.; Rotter, Jerome I.; Yang, Huiying; Targan, Stephan R.

doi:10.1053/j.gastro.2003.11.015

Cited by 462 publications

(389 citation statements)

References 39 publications

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“…Rather the response to commensal bacteria is characterized by development of regulatory T cells and secretion of IgA. By contrast, patients with IBD have aberrant T cell responses to the host flora (57,58) and express anti-microbial Abs that correlate with severity of disease (59). At least part of the reason for the normal hyporesponsiveness to commensal flora is the presence of regulatory CD4 ϩ CD25 ϩ T cells that secrete IL-10 (60, 61).…”

Section: Role Of Tlrs In the Regulation Of The Adaptive Immune Responmentioning

confidence: 99%

TLR Signaling in the Gut in Health and Disease

Abreu

Fukata

Arditi

2005

The Journal of Immunology

526

374

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The human intestine has evolved in the presence of diverse enteric microflora. TLRs convert the recognition of pathogen-associated molecules in the gut into signals for anti-microbial peptide expression, barrier fortification, and proliferation of epithelial cells. Healing of injured intestinal epithelium and clearance of intramucosal bacteria require the presence of intact TLR signaling. Nucleotide oligomerization domain (Nod)1 and Nod2 are additional pattern recognition receptors that are required for defense against invasive enteric pathogens. Through spatial and functional localization of TLR and Nod molecules, the normal gut maintains a state of controlled inflammation. By contrast, patients with inflammatory bowel disease demonstrate inflammation in response to the normal flora. A subset of these patients carry polymorphisms in TLR and CARD15/NOD2 genes. A better understanding of the delicate regulation of TLR and Nod molecules in the gut may lead to improved treatment for enteric infections and idiopathic inflammatory bowel diseases.

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Section: Role Of Tlrs In the Regulation Of The Adaptive Immune Responmentioning

confidence: 99%

TLR Signaling in the Gut in Health and Disease

Abreu

Fukata

Arditi

2005

The Journal of Immunology

526

374

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“…This gene encodes a protein directly involved in the innate immune response to microbial antigens. This fact and evidence derived from animal models and clinical studies [11][12][13] suggest that an inappropriate innate response to normal constituents of the luminal microflora plays a crucial role in the development of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

et al. 2009

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The aim of this study was to determine the role of the ATG16L1 (rs2241880) and IRGM (rs13361189 and rs4958847) genes polymorphism in Crohn's disease (CD) and ulcerative colitis (UC). Our study included 557 CD and 425 UC patients and 672 ethnically matched Spanish controls and a meta-analysis with the data published to date. The polymorphisms were genotyped using predesigned TaqMan single nucleotide polymorphism genotyping assays. There was a statistically significant difference in the distribution of the ATG16L1 rs2241880 G allele between CD patients and controls in the Spanish population: P ¼ 6.5 Â 10 À9 , odds ratio (OR) ¼ 1.62. Although no differences were observed between UC patients and controls in the Spanish cohort, a meta-analysis demonstrated that the ATG16L1 G allele increase significantly risk for UC (P ¼ 0.0003, pooled OR ¼ 1.08). In addition, our meta-analysis data showed that IRGM rs13361189 and rs4958847 polymorphisms were associated with CD (rs13361189 C allele P ¼ 1.07 Â 10 À19 , pooled OR ¼ 1.34; rs4958847 A allele P ¼ 2.78 Â 10 À17 , pooled OR ¼ 1.31) and UC (rs13361189 P ¼ 0.0069, pooled OR ¼ 1.16; rs4958847 P ¼ 0.014, pooled OR ¼ 1.13). In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.

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“…The inheritance is more commonly seen in CD than in UC [101,102]. Patients from IBD have activated innate and acquired immune responses and loss of tolerance to endogenous gut microbiota [103][104][105][106].…”

Section: Gastrointestinal Illnesses A) Clostridium Difficile Infectionmentioning

confidence: 99%

Commensal Bugs from the Gut-Shaping Human Health and Disease

Chowdhury¹

2014

JIG

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Association of antibody responses to microbial antigens and complications of small bowel Crohn’s disease

Cited by 462 publications

References 39 publications

TLR Signaling in the Gut in Health and Disease

TLR Signaling in the Gut in Health and Disease

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

Commensal Bugs from the Gut-Shaping Human Health and Disease

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