Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth

Venkatesh, Kartik K.; Riley, Laura E.; Castro, Víctor M.; Perlis, Roy H.; Kaimal, Anjali J

doi:10.1097/aog.0000000000001397

Cited by 41 publications

(29 citation statements)

References 25 publications

(23 reference statements)

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“…Third, we were unable to evaluate the treatment received for PTSD, so are unable to comment on how this might modify the association with obstetric complications. There is extensive research and debate over the potential effects of serotonin‐altering medications in pregnancy; whilst we could not explicitly adjust for the use of such medications, the observation that a current PTSD diagnosis but not current depression diagnosis was associated with our outcomes of interest makes it unlikely that this class of medications, which are most commonly used for depression, explains the association. Fourth, as in any observational work there is the possibility of unobserved and residual confounders.…”

Section: Commentmentioning

confidence: 99%

Post‐traumatic Stress Disorder and Antepartum Complications: a Novel Risk Factor for Gestational Diabetes and Preeclampsia

Shaw

Asch

Katon

et al. 2017

Paediatric Perinatal Epid

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Section: Commentmentioning

confidence: 99%

Post‐traumatic Stress Disorder and Antepartum Complications: a Novel Risk Factor for Gestational Diabetes and Preeclampsia

Shaw

Asch

Katon

et al. 2017

Paediatric Perinatal Epid

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“…9 In contrast to our findings, a recent study demonstrated an association of a positive screen for depression using Edinburgh Postnatal Depression Scale (EPDS) with preterm birth and SGA, but it noted that such risk was not apparent among women who were treated with an antidepressant medication. 27 The difference in results may be partially explained by methodology since in our study we identified patients with depression or anxiety based on ICD-9 coding and we compared identified patients with depression or anxiety with those who were not unaffected based on the use of psychotropic drugs. In the aforementioned study, patients were identified by EPDS, and all patients who received antidepressants (either screen-positive or screennegative) were compared with all those who did not use antidepressants (both screen-positive and screen-negative).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

AJP Rep

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Objective To determine independent perinatal associations of anxiety and depression in women who were and were not treated with psychotropic drugs in comparison to unaffected pregnancies. Study Design From 2013 to 2014, 978 (6.3%) cases of anxiety/depression, of which 35% used psychotropic drugs, were compared with 14,514 (93.7%) unaffected pregnancies using logistic regression. Results Subjects were more likely to be Non-Hispanic Whites, use tobacco and illegal substances, be unmarried, use public insurance, and have medical complications of pregnancy. For independent maternal outcomes, untreated anxiety/depression was associated with labor induction (adjusted odds ratio [aOR] ¼ 2.02), cesarean deliveries (aOR ¼ 1.69), longer length of stay (aOR ¼ 1.96), readmission (aOR ¼ 2.40), fever (aOR ¼ 2.03), magnesium exposure (aOR ¼ 1.82), and postpartum hemorrhage (aOR ¼ 2.57), whereas treated cases were associated with increased blood transfusion (aOR ¼ 4.81), severe perineal lacerations (aOR ¼ 2.93), and postpartum hemorrhage (aOR ¼ 3.85), but decreased risk of cesarean deliveries (aOR ¼ 0.59). Independent neonatal outcomes included small for gestational age (aOR ¼ 3.04), meconiumstained fluid (aOR ¼ 1.85; 2.61), respiratory failure (aOR ¼ 5.84), neonatal adaptation syndrome (aOR ¼ 11; 10.2), and neonatal seizures (aOR ¼ 12.3) in treated cases, whereas untreated cases were associated with hypoxia (aOR ¼ 2.83), low Apgar score (aOR ¼ 3.82), and encephalopathy (aOR ¼ 18.3). Exposure to multiple psychotropic medications independently increased the risk of neonatal adaptation syndrome, neonatal length of stay, and hypoglycemia. Conclusion Untreated cases were associated with increased maternal adverse outcomes, whereas treated cases were associated with more adverse neonatal outcomes when compared with unaffected pregnancies.

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“…For example, emotional distress may provoke unhealthy dietary patterns [28] and higher risk of preterm birth and low birth weight [29,30], which are in turn associated with higher risk for both clinical and subsyndromal mental disorders in offspring [31,32,33,34,35,36,37,38,39,40,41,42]. Importantly, subthreshold forms of depression can be identified in preschool children and represent a robust marker of subsequent clinical depression [43].…”

Section: Mental Health Societal Health: Avoiding Mother Blamementioning

confidence: 99%

Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective

Prescott

Logan²

2016

IJERPH

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The influential scientist Rene J. Dubos (1901–1982) conducted groundbreaking studies concerning early-life environmental exposures (e.g., diet, social interactions, commensal microbiota, housing conditions) and adult disease. However, Dubos looked beyond the scientific focus on disease, arguing that “mere survival is not enough”. He defined mental health as fulfilling human potential, and expressed concerns about urbanization occurring in tandem with disappearing access to natural environments (and elements found within them); thus modernity could interfere with health via “missing exposures”. With the advantage of emerging research involving green space, the microbiome, biodiversity and positive psychology, we discuss ecological justice in the dysbiosphere and the forces—financial inequity, voids in public policy, marketing and otherwise—that interfere with the fundamental rights of children to thrive in a healthy urban ecosystem and learn respect for the natural environment. We emphasize health within the developmental origins of health and disease (DOHaD) rubric and suggest that greater focus on positive exposures might uncover mechanisms of resiliency that contribute to maximizing human potential. We will entrain our perspective to socioeconomic disadvantage in developed nations and what we have described as “grey space”; this is a mental as much as a physical environment, a space that serves to insidiously reinforce unhealthy behavior, compromise positive psychological outlook and, ultimately, trans-generational health. It is a dwelling place that cannot be fixed with encephalobiotics or the drug-class known as psychobiotics.

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Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth

Abstract: In a large cohort of women screened for depression antepartum, those with depressive symptoms had an increased likelihood of preterm and very preterm delivery as well having an SGA neonate. Such risk was not apparent among women who were treated with an antidepressant medication.

Cited by 41 publications

References 25 publications

Post‐traumatic Stress Disorder and Antepartum Complications: a Novel Risk Factor for Gestational Diabetes and Preeclampsia

Post‐traumatic Stress Disorder and Antepartum Complications: a Novel Risk Factor for Gestational Diabetes and Preeclampsia

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Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective

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