Association of ANRIL polymorphisms with coronary artery disease

Abstract

Background: The long noncoding RNAs have gradually been reported to be an important class of RNAs with pivotal roles in the development and progression of myocardial infarction (MI). In this study, we hypothesized that genetic variant of cyclin-dependent kinase inhibitor 2B antisense RNA (ANRIL) may affect the prognosis of MI patients. Methods: A systematic review and meta-analysis of studies including 11,269 cases and 10,707 controls on the association of 5 ANRIL single nucleotide polymorphism and the overall risk of MI or coronary artery disease (CAD) was performed. Results: In the meta-analysis, rs4977574 A > G, rs1333040 C > T, rs1333042 A > G and rs10757274 A > G ANRIL polymorphisms were correlated with overall MI or CAD risk. No significant associations were found between ANRIL rs1333049 G > C polymorphism and CAD risk. Conclusions: The results indicated that ANRIL polymorphism (rs4977574, rs1333040, rs1333042, and rs10757274) were more generally associated with CAD or MI risk. Further experimental studies to evaluate the limits of this hypothesis are warranted, and future functional studies are required to clarify the possible mechanisms.

CDKN2B‐AS1 gene rs4977574 A/G polymorphism and coronary heart disease: A meta‐analysis of 40,979 subjects

“…52,53 The CDKN2B-AS1 gene rs1333040C>T, rs1333042 A>G and rs10757274 A>G variants might also affect the pathogenesis of CHD patients. 50 In sum, CDKN2B-AS1 gene rs4977574 polymorphism was evidently relevant to CHD risk, particularly in the Asian population.…”

“…The microeffects of other genes involved in CHD have yet to be adequately clarified (eg PCSK9 gene E670G polymorphism and TGF ‐ β1 gene‐509C/T polymorphism) 52,53 . The CDKN2B ‐ AS1 gene rs1333040C>T, rs1333042 A>G and rs10757274 A>G variants might also affect the pathogenesis of CHD patients 50 …”

“…In 2020, Zhang et al performed a meta‐analysis on this subject and obtained a similar conclusion. 50 Nevertheless, they also included studies deviating from HWE. In addition, they mixed Asian and Caucasian studies and did not divide them into two subgroups.…”

“…Several new studies published after 2018 were also included. In 2020, Zhang et al performed a meta-analysis on this subject and obtained a similar conclusion 50. Nevertheless, they also included studies deviating from HWE.…”

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

“…LncRNA ANRIL is the prime candidate gene at Chr9p21 and widely recognized as a critical part of endothelial inflammation and cell proliferation (91,(94)(95)(96)(97). Single nucleotide polymorphisms (SNPs) and splice variants of ANRIL were reported to regulate endothelial cell activities involved in coronary artery heart disease (CAD) and MI (98)(99)(100)(101)(102)(103). Abnormal expression of ANRIL is associated with vascular endothelium injury and proliferation, migration, and apoptosis of VSMCs; which also contribute to mononuclear cell adhesion and proliferation (104,105).…”