Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.

Pei, York; Scholey, James W.; Thai, Kerri; Suzuki, Masataka; Cattran, Daniel C.

doi:10.1172/jci119596

Cited by 113 publications

(106 citation statements)

References 41 publications

(57 reference statements)

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“…Moreover, in the stratified analysis relating to ethnicity, our results indicated that the A1166C polymorphism was not associated with IgAN risk in Asians. However, as only one paper involving a Caucasian population was identified (Pei et al, 1997), further studies focusing on Caucasian patients should be carried out in future. No publication bias was evident in this meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, five studies published between 1997 and 2013 were included in our meta-analysis (Pei et al, 1997;Maruyama et al, 2001;Lau et al, 2004;Huang et al, 2010;You et al, 2013), incorporating 579 IgAN cases and 483 controls (Figure 1). One involved Caucasian subjects (Pei et al, 1997), while four focused on Asian populations (Maruyama et al, 2001;Lau et al, 2004;Huang et al, 2010;You et al, 2013). The countries in which these investigations were carried out included Canada, Japan, Singapore, and China.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis

Jm¹,

Song²,

Gao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a metaanalysis. Articles were identified in the PubMed, Google Scholar, and China National Knowledge Infrastructure databases, and after selection, five eligible studies were included. Statistical analyses were carried out using Stata 12.0, combining data from all the relevant studies. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 19371-19381 (2015) AC vs AA+CC: OR = 0.96, 95%CI = 0.70-1.31]. In conclusion, the AGTR1 gene A1166C polymorphism may not be correlated with IgAN susceptibility. However, further studies should be performed to confirm this finding.

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Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis

Jm¹,

Song²,

Gao³

et al. 2015

Genet. Mol. Res.

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“…Polymorphic variations in the human AGT gene have been shown to be associated with 18 an increased risk of essential hypertension, [18][19][20][21][22] and a decline in renal function. 23 Although it is possible that the AGT gene polymorphisms influence gemcitabine PK through yet unknown mechanisms, the result and the suggested hypothesis in our study should be evaluated both in replication study using another sample set and also in biological functional analyses. Many biomedical researchers have used the KruskalWallis test for finding significant SNPs, and visually checked PK-genotype response patterns.…”

Section: Discussionmentioning

confidence: 81%

A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies

et al. 2008

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Biomedical researchers usually test the null hypothesis that there is no difference of the population mean of pharmacokinetics (PK) parameters between genotypes by the Kruskal-Wallis test. Although a monotone increasing pattern with a number of alleles is expected for PK-related genes, the Kruskal-Wallis test does not consider a monotonic response pattern. For detecting such patterns in clinical and toxicological trials, a maximum contrast method has been proposed. We show how that method can be used with pharmacogenomics data to a develop test of association. Further, using simulation studies, we compare the power of the modified maximum contrast method to those of the maximum contrast method and the KruskalWallis test. On the basis of the results of those studies, we suggest rules of thumb for which statistics to use in a given situation. An application of all three methods to an actual genome-wide pharmacogenomics study illustrates the practical relevance of our discussion.

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“…7). Studies have found that the DD genotype is associated with a more rapid loss of renal function in diabetic nephropathy, 23 IgA nephropathy 24 and adult polycystic kidney disease, 25 when compared to the II or DI genotypes. The genotype does not appear to initiate or cause renal disease per se; rather it is associated with more rapid loss of renal function after disease development.…”

Section: Discussionmentioning

confidence: 99%

Loss of renal function following bone marrow transplantation: an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors

Juckett

Cohen

Keever-Taylor

et al. 2001

Bone Marrow Transplant

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Summary:Chronic renal failure is an acknowledged late complication of BMT. It is related to the intensive chemotherapy, radiation and supporting medications. Polymorphism in the angiotensin converting enzyme (ACE) gene is associated with progression of nephropathy caused by diabetes and IgA nephropathy. We sought to determine whether ACE genotype and other clinical factors were associated with loss of renal function after BMT. We determined the genotype of 106 adult allogeneic BMT recipients, who received a similar preparative regimen, survived 1 year, and had assessment of renal function up to 3 years after BMT. We found that the distribution of genotypes was similar to the general population; 29%, 51%, and 20% for the DD, DI, and II genotypes, respectively. There was no statistical difference in patient survival between the three groups. Among all patients, the average creatinine clearance declined from 124 (95% CI 117, 131) to 89 (95% CI 78, 100) ml/min over the 36 months after BMT. Decline in renal function over time was less for patients with the DD compared to the II genotype (P = 0.040). Renal function in patients with the DD genotype was also better than those with the DI genotype, but this was of borderline statistical significance (P = 0.055). Renal shielding reduced decline in renal function compared to no shielding (P = 0.026). We conclude that the ACE genotype does not seem to influence survival, but the DD genotype may be protective against renal injury after BMT. Furthermore, we confirm that renal shielding during TBI reduces the renal injury after BMT. Bone Marrow Transplantation (2001) The late occurrence of chronic renal failure is a known complication of allogeneic bone marrow transplantation. 1 The combined effects of intensive radiation and chemotherapy are implicated in the pathogenesis of acute and chronic renal insufficiency. Factors contributing to acute renal failure include hypotension, sepsis and the administration of nephrotoxic medications such as aminoglycoside antibiotics, cyclosporine, tacrolimus and amphotericin. A distinct syndrome of chronic renal failure after BMT termed 'bone marrow transplant nephropathy' has been described that consists of azotemia, disproportionate anemia, and hypertension. 2,3 This syndrome is thought to be due to either microvascular or renal parenchymal damage from the preparative regimen and in its most severe form resembles hemolytic uremic syndrome (HUS).Studies using animal models of BMT nephropathy have shown that angiotensin converting enzyme (ACE) inhibitors can effectively prevent and treat the syndrome. 4,5 This finding implicates the renin-angiotensin axis in the pathogenesis of the disorder. ACE is responsible for the cleavage of angiotensin I to angiotensin II, which has potent effects on vascular tone, growth and repair. The ACE gene contains a polymorphism based on the presence or absence of a 287-base pair intron. 6 The presence of the intron has been termed the 'insertion' or 'I' allele, and the absence of the intron the 'deletion' or...

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Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.

Cited by 113 publications

References 41 publications

Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis

Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis

A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies

Loss of renal function following bone marrow transplantation: an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors

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