Association of angiotensin-converting enzyme insertion/deletion polymorphism with type 1 diabetic nephropathy: a meta-analysis

Xu, Haiyan; Liu, Mingming; Wang, Xu; He, Xueyuan

doi:10.1080/0886022x.2016.1216707

Cited by 7 publications

(4 citation statements)

References 20 publications

(19 reference statements)

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“…However, the correlation between ACE I/D and DN remains controversial. Our findings from the present meta-analysis are consistent with the findings of the previous meta-analyses, in which significant association between the ACE gene I/D and DN risk was inferred (65)(66)(67). In support of this higher ACE activity level was documented in DD and ID+DD carriers (40).…”

Section: Discussionsupporting

confidence: 92%

Genetic association of ACE gene I/D polymorphism with the risk of diabetic kidney disease; a meta-analysis

et al. 2019

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Introduction: Diabetic nephropathy (DN) is a progressive renal disease characterized by persistent albuminuria that leads to end-stage renal disease in both type 1 diabetes (T1DM) and type 2 diabetes (T2DM) patients. The renin-angiotensin-aldosterone system (RAAS) plays a major role in the onset and progression of DN. Objectives: The present meta-analysis is intended to synthesize evidence on the association between ACE gene insertion and deletion (ACE I/D) polymorphism and the risk of DN. Methods: PubMed, Scopus, Google Scholar and Embase were searched to retrieve relevant publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association between ACE I/D polymorphism and DN risk. The Cochrane Q test and I2 statistic were used to detect heterogeneity. To assess between-study heterogeneity, subgroup analysis and sensitivity analysis were performed. Funnel plots and Egger’s test were used to estimate publication bias. Results: Around 45 articles (47 studies) with 6124 patients of DN and 2492 T2DM patients (controls) were ultimately considered for meta-analysis. Overall, the ACE I/D polymorphism was associated with DN under three different genetic models (allelic model: OR = 1.34; 95% CI: 1.20- 1.49; P<0.001; dominant model: OR= 1.54; 95% CI: 1.31- 1.81; P<0.001; and recessive model: OR= 1.39; 95% CI: 1.19- 1.63; P<0.001). Significant heterogeneity (I2 > 50%) was present in the analysis for all ethnic groups. Further, there is no evidence for publication bias in this meta-analysis. Conclusion: The current meta-analysis provided confirmation that the ACE I/D polymorphism is correlated with an increased risk of DN in patients with T2DM and the D allele of ACE I/D was a susceptible factor.

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Section: Discussionsupporting

confidence: 92%

Genetic association of ACE gene I/D polymorphism with the risk of diabetic kidney disease; a meta-analysis

et al. 2019

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“…The more severe prognosis of patients of older age may also been related to distinct mechanisms, such as the age-associated decline in the molecular machinery involved in removing cytosolic DNA [98]. Also, patients with hypertension or diabetes show high rate of ACE2 genetic polymorphism that could influence ACE2 or Ang1-7 levels in the human body [64,[99][100][101]. Therefore, a negative correlation between ACE2 expression and mortality has been suggested [64].…”

Section: Aceis/arbs Treatment During the Covid-19 Pandemicmentioning

confidence: 99%

COVID‐19 and renin‐angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) ‐ Is there any scientific evidence for controversy?

et al. 2020

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Renin–angiotensin system (RAS) blockers are extensively used worldwide to treat many cardiovascular disorders, where they are effective in reducing both mortality and morbidity. These drugs are known to induce an increased expression of angiotensin‐converting enzyme 2 (ACE2). ACE2 acts as receptor for the novel SARS coronavirus‐2 (SARS‐CoV‐2) which raising the important issue of possible detrimental effects that RAS blockers could exert on the natural history and pathogenesis of the coronavirus disease‐19 (COVID‐19) and associated excessive inflammation, myocarditis and cardiac arrhythmias. We review the current knowledge on the interaction between SARS‐CoV‐2 infection and RAS blockers and suggest a scientific rationale for continuing RAS blockers therapy in patients with COVID‐19 infection.

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“…13,[27][28][29][30][31][32][33][34][35] Other meta-analysis reports performed in different diabetic diseases confirm significant association. [36][37][38] The strength of this current study was implemented the purely Saudi women to identify the accurate risk in the Saudi population. The non-Saudi women has been excluded as this is a major part of this study.…”

Section: Discussionmentioning

confidence: 99%

Genetic association between angiotensin converting enzyme gene in Saudi obese women established gestational diabetes; Non-replication of case-control studies in insertion and deletion polymorphism

Alodhayani

2018

Preprint

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Introduction: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance detected during pregnancy and resolves after delivery. Presently, GDM was identified with biochemical but not with molecular analysis. Therefore, this study investigated the genetic, biochemical, clinical association between ACE polymorphism in GDM women.Methods: In this case-control study, 400 pregnant women were selected to inspect the ACE genotyping. Two hundred GDM cases were compared with 200 non-GDM subjects.Genotyping was carried out with direct primer sequence followed with 3% agarose gel electrophoresis. Results: Statistical association was identified between GDM and non-GDM subjects with D allele, ID genotype and dominant model (D vs I: OR-1.62 [95%CI: 1.09-2.41]; p=0.01; ID vs II: OR-1.58 [95%CI: 1.02-2.42]; p=0.03; DD+ID vs II; OR-1.62 [95%CI: 1.09-2.40]; p=0.01). when comparison was carried out in obese and non-obese of GDM subjects' negative association was confirmed (p>0.05) and Weight cum BMI associated positively with ACE II, ID and DD genotypes (p=0.07 and p=0.02). Conclusion: This results confirm positive association with ACE variant in GDM subjects;confirms the association between GDM and obesity in Saudi women. However, future studies should be implement in other diseases in Saudi as well as GDM with obesity studies in global populations to rule out the diseases.

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Association of angiotensin-converting enzyme insertion/deletion polymorphism with type 1 diabetic nephropathy: a meta-analysis

Abstract: Objective: This study aimed to systematically evaluate the effect of an angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism on type 1 diabetic nephropathy (DN

Cited by 7 publications

References 20 publications

Genetic association of ACE gene I/D polymorphism with the risk of diabetic kidney disease; a meta-analysis

Genetic association of ACE gene I/D polymorphism with the risk of diabetic kidney disease; a meta-analysis

COVID‐19 and renin‐angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) ‐ Is there any scientific evidence for controversy?

Genetic association between angiotensin converting enzyme gene in Saudi obese women established gestational diabetes; Non-replication of case-control studies in insertion and deletion polymorphism

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