2018
DOI: 10.1055/s-0038-1672137
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Association of Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism with Recurrent Pregnancy Loss: a Meta-Analysis of 26 Case-Control Studies

Abstract: Objective Previous studies investigating the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and recurrent pregnancy loss (RPL) risk has provided inconsistent results. The aim of our study was to assess the association between the ACE I/D polymorphism and risk of RPL. Methods All studies published up to January 30, 2018 on the association of ACE I/D polymorphism with RPL were identified by searching the PubMed, Web of Knowledge, and Google scholar … Show more

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Cited by 9 publications
(17 citation statements)
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“…The most common and significant DNA polymorphism detected in the ACE gene is the I/D polymorphism (rs4646994) (10,25). The I/D polymorphism is an insertion or deletion of a 287 bp fragment in intron 16 (10,25).…”
Section: The Insertion/deletion (I/d) Polymorphism In the Ace Genementioning
confidence: 99%
See 4 more Smart Citations
“…The most common and significant DNA polymorphism detected in the ACE gene is the I/D polymorphism (rs4646994) (10,25). The I/D polymorphism is an insertion or deletion of a 287 bp fragment in intron 16 (10,25).…”
Section: The Insertion/deletion (I/d) Polymorphism In the Ace Genementioning
confidence: 99%
“…The most common and significant DNA polymorphism detected in the ACE gene is the I/D polymorphism (rs4646994) (10,25). The I/D polymorphism is an insertion or deletion of a 287 bp fragment in intron 16 (10,25). The D allele is associated with elevated plasma ACE levels and, thus, with enhanced ACE activity (11) More specifically, the homozygotes for the D allele (D/D) tend to have twice higher levels of the encoded enzyme circulating in blood plasma in comparison with individuals homozygous for the I allele (I/I), which is linked to the lowest ACE levels (26).…”
Section: The Insertion/deletion (I/d) Polymorphism In the Ace Genementioning
confidence: 99%
See 3 more Smart Citations