Association of angiotensin-converting enzyme (ACE) and fatty acid binding protein 2 (FABP2) genes polymorphism with type 2 diabetes mellitus in Northern India

Abstract

Background: Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world with an expected doubling of the incidence to millions of affected individuals in the last decades. At present, adequate data are not available regarding the ACE and FABP2 polymorphisms and their susceptibility with T2DM cases in the North Indian population. Thus we conceived the need for further study of ACE (I/D) and FABP2 (Ala54Thr) genes polymorphism and its susceptibility to T2DM in the North Indian population. Materials and methods:In this study, a total of 300 subjects (including 190 T2DM cases and 110 controls) participated. ACE and FABP2 gene polymorphisms in the cases and controls were evaluated by polymerase chain reaction and restriction fragment length polymorphism. Results: The frequencies of ACE I/I, I/D and D/D genotypes in T2DM cases and controls were 28.73%, 55.17%, 16.09% and 13.63%, 57.95%, 28.40%, respectively. The frequencies of FABP2 Ala54Ala, Ala54Thr and Thr54Thr in T2DM cases were 18.39%, 66.66%, 14.94% and 22.72%, 61.36%, 15.90% in controls, respectively. ACE I/I genotype was significantly more frequent in cases as compared to controls (p = 0.003, χ 2 = 9.13).Conclusion: It appears that the ACE I/I genotype frequency was significantly higher in the T2DM cases as compared to the controls.

Association between FABP2 Ala54Thr polymorphisms and type 2 diabetes mellitus risk: a HuGE Review and Meta‐Analysis

“…A total of thirteen publications involving 2020 T2DM cases and 2910 controls met the inclusion criteria and were ultimately analysed . Table presents the main characteristics of these studies.…”

The intestinal fatty acid binding protein-2 Ala54Thr polymorphism is associated with diabetic retinopathy in Chinese population

“…Genomic DNA was prepared from white blood cells using the Puregene® DNA Isolation kit (Gentra Systems, Inc.). The genotyping of the Ala54Thr polymorphism was performed by PCR amplification as previously described [ 3 , 7 ]. For all samples, reading of the genotype was independently carried out by two individuals.…”

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Glutathione S-transferase (T1 & M1) Null Genotypes as Risk Determinants in Sudanese for Developing Type Two Diabetes Mellitus

“…GTTs have an essential role in the detoxification of oxidative stress products, which are one of many risks factors that may be associated with several types of disease affect processes such as T2DM (Sombié et al, 2020). T2DM is growing in a quick manner whole over the world (Raza et al, 2014a;2014b). Type 2 diabetes is also one of the multifactorial disorders with heterogeneous disturbances of metabolism, the genetics and environmental factors playing important role in its causes (Dadbinpour et al, 2013;Kerner and Brückel, 2014).…”