Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer

Vairaktaris, Eleftherios; Yapijakis, Christos; Tsigris, Christos; Vassiliou, Stavros; Derka, Spyridoula; Nkenke, Emeka; Spyridonidou, Sofia; Vylliotis, Antonis; Vorris, E.; Ragos, Vasileios; Neukam, Friedrich Wilhelm; Patsouris, Efstratios

doi:10.1080/02841860701373579

Cited by 26 publications

(15 citation statements)

References 21 publications

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“…28 A case-control study showed that the I/D polymorphism, by affecting the ACE gene expression, was associated with the progress of oral oncogenesis. 29 Another study showed that ACE was expressed locally in gastric cancer and that the I/D polymorphism influenced metastatic behavior. 30 A case-control study showed that the ACE I/D polymorphism might be linked to the development of early gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion gene polymorphisms is associated with risk of glioma in a Chinese population

Lian

Jiang

Wang

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Introduction:The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has recently been linked to the pathogenesis and progression of human cancers. The aim of this study was to evaluate the potential association between ACE I/D polymorphism and glioma in a Chinese population. Materials and methods: A case-control study involving patients with 800 glioma and 800 controls was conducted. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the ACE I/D genotypes. Results: Glioma cases had a significantly higher frequency of DD genotype [odds ratio (OR) = 1.61, 95% confidence interval (CI) = 1.12, 2.32; p = 0.01] than controls. When stratified by the grade of glioma, cases with WHO IV glioma had a significantly higher frequency of DD genotype (OR = 1.51, 95% CI = 1.03, 2.21; p = 0.03). When stratified by the histology of glioma, there was no significant difference in the distribution of each genotype. Conclusion: Our study suggested that the ACE DD genotype was associated with a higher glioma risk in this Chinese population. To the best of our knowledge, this is the first report describing the potential association between ACE I/D polymorphism and glioma. Additional studies are needed to confirm this finding.

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Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion gene polymorphisms is associated with risk of glioma in a Chinese population

Lian

Jiang

Wang

et al. 2014

J Renin Angiotensin Aldosterone Syst

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“…The angiotensin-converting enzyme (ACE), a key enzyme in the renin-angiotensin system, plays the important roles of regulating of blood pressure and serum electrolytes [1,2]. It has also been implicated in the pathogenesis of several cancers, such as lung cancer, breast cancer, prostate cancer, gastric cancer and oral cancer [2-6].…”

Section: Introductionmentioning

confidence: 99%

“…It has also been implicated in the pathogenesis of several cancers, such as lung cancer, breast cancer, prostate cancer, gastric cancer and oral cancer [2-6]. It is differentially expressed in several carcinomas and may affect tumor cell proliferation, migration, angiogenesis, and metastatic behaviors [7].…”

Section: Introductionmentioning

confidence: 99%

The insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme gene and cancer risk: a meta-analysis

Zhang

Deng

et al. 2011

BMC Med Genet

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BackgroundThe insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to cancer, but a large number of studies have reported inconclusive results. The aim of this study is to assess the association between the I/D polymorphism in the ACE gene and cancer risk by meta-analysis.MethodsA search was performed in Pubmed database, Embase database, Chinese Biomedical (CBM) database, China National Knowledge Infrastructure (CNKI) database and Weipu database, covering all studies until August 31, 2010. Statistical analysis was performed by using Revman4.2 and STATA 10.0.ResultsA total of 25 case-control studies comprising 3914 cancer patients and 11391 controls were identified. No significant association was found between the I/D polymorphism and over all cancer risks (OR = 0.88, 95%CI = 0.73-1.06, P = 0.17 for DD+DI vs. II). In the subgroup analysis by ethnicity, no significant association was found among Asians and Europeans for the comparison of DD+DI vs. II. In the subgroup analysis by cancer types, no significant associations were found among lung cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated the lack of associations between this polymorphism and cancer risks.ConclusionsThis meta-analysis suggested that the ACE D/I polymorphism might not contribute to the risk of cancer.

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“…32 Moreover, some researchers reported that the II genotype was associated with a significantly increased risk of breast cancer 18,19 and oral cancer. 37 Although the reason for these discrepancies remains unknown, it is likely that the ACE I/D polymorphism may have different roles in different cancer types. This phenomenon was confirmed by a recently published metaanalysis study that reported a significantly decreased incidence of the ACE I/D polymorphism in patients with prostate cancer or breast cancer, but not in patients with colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…11 It has been reported that individuals with the D allele have higher plasma ACE activity. [11][12][13] Recently, numerous studies have been carried out to examine the association between the ACE I/D polymorphism and susceptibility to a range of cancers, including breast cancer, 14-21 gastric cancer, [22][23][24][25][26] colorectal cancer, [27][28][29][30][31] prostate cancer, [32][33][34] lung cancer, 35,36 oral cancer, 37,38 and renal cancer. 39 No studies to date have evaluated the relationship between the ACE I/D polymorphism and NPC risk.…”

Section: Introductionmentioning

confidence: 99%

No association betweenACEolymorphism and risk of nasopharyngeal carcinoma

Pan

Han

et al. 2011

J Renin Angiotensin Aldosterone Syst

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Emerging evidence has shown that angiotensin I-converting enzyme (ACE) plays pivotal roles not only in the regulation of cardiovascular homeostasis but also in the process of tumorigenesis. A common ACE I/D polymorphism has been found to be functional, with the D allele displaying a higher plasma ACE level and ACE activity. The purpose of this study was to investigate whether the ACE I/D polymorphism was related to the risk of nasopharyngeal carcinoma (NPC). The study included 175 patients with NPC and 279 age-and sex-matched control subjects.

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Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer

Abstract: These findings suggest that the I/D polymorphism, by affecting the ACE gene expression, is associated with the progress of oral oncogenesis.

Cited by 26 publications

References 21 publications

Angiotensin-converting enzyme insertion/deletion gene polymorphisms is associated with risk of glioma in a Chinese population

Angiotensin-converting enzyme insertion/deletion gene polymorphisms is associated with risk of glioma in a Chinese population

The insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme gene and cancer risk: a meta-analysis

No association betweenACEolymorphism and risk of nasopharyngeal carcinoma

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