Association of angiotensin converting enzyme gene insertion/deletion polymorphism with lung cancer in Turkey

Nacak, Muradiye; Nacak, İbrahim; Şanlı, Maruf; Özkur, Mehtap; Pektaş, Mehtap; Aynacıoğlu, A. Şükrü

doi:10.1016/j.cancergencyto.2009.11.019

Cited by 28 publications

(31 citation statements)

References 36 publications

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“…46 The frequency of the D allele among controls in our study, which was 0.51, is lower than the study in the Malaysian population 41 and approximately lower than in the Turkish population. 47 54 The inconsistency in results might be explained by the genetic and environmental heterogeneity among different ethnic groups, differences in ACE inhibitors 55 used and study sample size. The conflicting results among the various populations led us to determine the relationship between the ACE I/D gene polymorphism and BP response to an ACEIs enalapril and lisinopril in an appropriate sample size of 142 Malay male hypertensive subjects.…”

Section: Discussionmentioning

confidence: 99%

Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene among Malay male hypertensive subjects in response to ACE inhibitors

Heidari

Ramachandran

Ali³

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Introduction: Several studies show that the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with hypertension in various populations. The present study sought to determine the association of the I/D gene polymorphism among Malay male essential hypertensive subjects in response to ACE inhibitors (enalapril and lisinopril). Materials and methods: A total of 72 patients with newly diagnosed hypertension and 72 healthy subjects were recruited in this study. Blood pressure was recorded from 0 to 24 weeks of treatment with enalapril or lisinopril. Genotyping of the I/D polymorphism was carried out using a standard PCR method. Results: Statistically significant association of the D allele of the ACE gene was observed between the case and control subjects (p < 0.01). There was a decrease in blood pressure in the patients carrying the DD genotype (SBP=18.5±8.1 mmHg, DBP=15.29±7.1 mmHg) rather than the ID (SBP=4.1±3.3 mmHg, DBP=9.1±3.5 mmHg) and II genotypes (SBP= 3.0±0.2 mmHg, DBP 0.11±6.1 mmHg) of the ACE gene. Conclusion: Patients carrying the DD genotype had higher blood pressure-lowering response when treated with ACE inhibitors enalapril or lisinopril than those carrying ID and II genotypes, suggesting that the D allele may be a possible genetic marker for essential hypertension among Malay male subjects.

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Section: Discussionmentioning

confidence: 99%

Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene among Malay male hypertensive subjects in response to ACE inhibitors

Heidari

Ramachandran

Ali³

et al. 2014

J Renin Angiotensin Aldosterone Syst

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show abstract

“…24 A case-control study suggested that the ACE I/D polymorphism could be a risk factor for patients with lung cancer in Turkey. 25 A case-control study indicated that the ID genotype of the ACE gene might be protective against breast cancer among Brazilian women. 26 A casecontrol study suggested that the DD genotype of the ACE gene might accompany poor prognostic factors and influence the tumor course of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion gene polymorphisms is associated with risk of glioma in a Chinese population

Lian

Jiang

Wang

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Introduction:The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has recently been linked to the pathogenesis and progression of human cancers. The aim of this study was to evaluate the potential association between ACE I/D polymorphism and glioma in a Chinese population. Materials and methods: A case-control study involving patients with 800 glioma and 800 controls was conducted. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the ACE I/D genotypes. Results: Glioma cases had a significantly higher frequency of DD genotype [odds ratio (OR) = 1.61, 95% confidence interval (CI) = 1.12, 2.32; p = 0.01] than controls. When stratified by the grade of glioma, cases with WHO IV glioma had a significantly higher frequency of DD genotype (OR = 1.51, 95% CI = 1.03, 2.21; p = 0.03). When stratified by the histology of glioma, there was no significant difference in the distribution of each genotype. Conclusion: Our study suggested that the ACE DD genotype was associated with a higher glioma risk in this Chinese population. To the best of our knowledge, this is the first report describing the potential association between ACE I/D polymorphism and glioma. Additional studies are needed to confirm this finding.

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“…In recent years there are many studies that investigated the incidence of specific thrombophilic gene mutations in lung cancer. Some showed significant association (Bennet et al, 2007;Dahlback, 2008;Nacak et al, 2010;Kiyohara et al, 2011;Su et al, 2011;Tug et al, 2011) but still some reports showed lack of any association (Liu et al, 2009;Arslan et al, 2011;Dević et al, 2012;Zhang et al, 2012). According to the some resent reports the high portion of lung cancers in never smokers may be attributable to heritable different molecular genetic and epigenetic parameters.…”

Section: Introductionmentioning

confidence: 99%

“…Nacak et al (2010) showed decreased ACE enzyme activity and plasma concentrations that associated with poor prognosis in lung cancer (Nacak et al, 2010). A meta-analysis of ACE gene I/D polymorphism suggest that the ACE gene A-240T polymorphism might be a genetic marker for the development of lung cancer .…”

mentioning

confidence: 99%

Combined Germline Variations of Thrombophilic Genes Promote Genesis of Lung Cancer

Özen

Polat²,

Arslan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Association of angiotensin converting enzyme gene insertion/deletion polymorphism with lung cancer in Turkey

Cited by 28 publications

References 36 publications

Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene among Malay male hypertensive subjects in response to ACE inhibitors

Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene among Malay male hypertensive subjects in response to ACE inhibitors

Angiotensin-converting enzyme insertion/deletion gene polymorphisms is associated with risk of glioma in a Chinese population

Combined Germline Variations of Thrombophilic Genes Promote Genesis of Lung Cancer

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