Association of anemia with functional and nutritional status in the German multicenter study “GeriAnaemie2013”

Röhrig, Gabriele; Rücker, Ymkje; Becker, Ingrid; Schulz, Ralf-Joachim; Lenzen-Großimlinghaus, R.; Willschrei, Peter; Gebauer, Sybille; Modreker, Mirja Katrin; Jäger, Martin; Wirth, Rainer

doi:10.1007/s00391-016-1092-3

Cited by 12 publications

(8 citation statements)

References 29 publications

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“… 21 Preliminary results of the first German multi-center study on anemia prevalence among geriatric inpatients found a prevalence of >55% and confirmed the previous findings of the monocentric studies. 22 …”

Section: Anemia In the Agedmentioning

confidence: 99%

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Anemia in the frail, elderly patient

Röhrig¹

2016

CIA

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103

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Anemia and frailty are two common findings in geriatric patients and have been shown to be associated with poor outcomes in this patient group. Recent studies have contributed to the growing evidence of a possible association with the age-related chronic inflammatory status known as “inflammaging”. These findings do not only give a better insight into the pathogenesis of anemia in frailty, but also offer new treatment options. The present article focuses on this assumed association between anemia, frailty, and inflammaging and summarizes current management options for anemia in frail patients.

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Section: Anemia In the Agedmentioning

confidence: 99%

“… 18 This finding was confirmed by the German multicenter study on anemia prevalence among geriatric inpatients. 22 …”

Section: Anemia In the Agedmentioning

confidence: 99%

Anemia in the frail, elderly patient

Röhrig¹

2016

CIA

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103

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“…Our results also showed that patients with OPC had a higher incidence of critical weight loss and grade 3–4 anaemia than patients without OPC during RT. Weight loss and anaemia are commonly used indicators of malnutrition [ 24 – 26 ]. In cancer patients, a variety of factors, including the tumour, the host response to the tumour, and anticancer treatment, may cause malnutrition and cachexia [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of 606 cases of nasopharyngeal carcinoma with or without oropharyngeal candidiasis during radiotherapy

Qiu

Xia

et al. 2017

PLoS ONE

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BackgroundTo evaluate the clinical characteristics, treatment-related toxicities and survival in patients with nasopharyngeal carcinoma (NPC) with or without oropharyngealcandidiasis (OPC) during radiotherapy.MethodsThe current study was conducted with NPC patients undergoing radiotherapy at Sun Yat-Sen University Cancer Center between June 2011 and May 2012. A clinical diagnosis of candidiasis was determined on the basis of a positive potassium hydroxide (KOH) test and the presence of pseudomembranous (white) form of candidal overgrowth. The Cox proportional hazard regression model was used to test the association of OPC and related survival rates.ResultsCompared with the non-OPC group, the OPC group had significantly increased occurrence rates of grade 3–4 mucositis (14.5% vs. 7.4%, P = 0.049), anaemia (11.3% vs. 4.4%, P = 0.020), hepatotoxicity (4.8% vs. 1.1%, P = 0.021) and critical weight loss (85.5% vs. 56.6%, P<0.001) during radiotherapy. The OPC group had a significantly lower disease-free survival (DFS) (70.9% vs. 82.6%, P = 0.012), mainly as a result of a reduction in locoregional relapse-free survival (LRFS) (87.0%vs. 94.9%, P = 0.025). After stratification by T stage, the 5-year DFS in T3-4 patients were 82.0% and 68.8% in non-OPC and OPC groups, respectively (P = 0.022). Multivariate analyses indicated that OPC was a prognostic factor for LRFS and DFS.ConclusionsOPC during radiotherapy may worsen the nutritional status of NPC patients according to weight loss and anaemia, leading to a negative impact on 5-year locoregional relapse-free survival and disease-specific survival. Further investigations are needed to explore whether prevention and treatment of OPC during radiotherapy will be useful.

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“…Although, polymedication was considered independent risk factor for anemia, a 12-35% higher chance of anemia was seen in aspirin users alone. Other drugs like corticosteroids and anti-acids were also seen associated with IDA [43,44]. Screening for under nutrition should be included in assessment of anemia in geriatric patients as low serum albumin levels are found as independent risk factors for anemia in geriatric patients [44,45].…”

Section: Etiopathogenesismentioning

confidence: 99%

Geriatric Anemia

Rana¹,

Rana²

2021

Update in Geriatrics

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Anemia is growing in importance as a public health issue and a biomedical research priority in the geriatric age group but data on the causes and prevalence is not substantial. World health organization (WHO) has defined anemia as hemoglobin concentration (Hb %) below 12 g/dL in women and below 13 g/dL in men. Although it was previously believed that decline in Hb levels might be a normal consequence of aging, later suggested that anemia does reflect underlying poor health and makes elders vulnerable to adverse outcomes. Geriatric anemia has been found to be prevalent in up to 21.1% of patients in Europe and 11.0% of men and 10.2% of women of 65 years and older in the US. There is little literature that explores the various causes of anemia and its association with socio-demographic profile with underlying diseases, hence lesser research has led anemia to go undiagnosed and untreated.

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Association of anemia with functional and nutritional status in the German multicenter study “GeriAnaemie2013”

Abstract: Polymedication and low serum albumin were independent risk factors for anemia in geriatric patients, probably reflecting disease severity.

Cited by 12 publications

References 29 publications

Anemia in the frail, elderly patient

Anemia in the frail, elderly patient

A retrospective study of 606 cases of nasopharyngeal carcinoma with or without oropharyngeal candidiasis during radiotherapy

Geriatric Anemia

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