Association of Androgen Receptor (AR) CAG Repeats and Cytochrome P450 3A5*3 (CYP3A5*3) Gene Polymorphisms in South Indian Men with Prostate Cancer

Daram, Swarnalatha; Zubeda, Syeda; Poornima, Subhadra; Boppana, Srinadh; Prabhala, Shailaja; Annamaneni, Sandhya; D, Ramakrishna; Hasan, Qurratulain

doi:10.7860/jcdr/2019/41564.13077

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“…The base line clinical characteristics of the cohort studied have been discussed in our previous publication [20].…”

Section: Results and Discussion Clinical Characteristicsmentioning

confidence: 99%

“…Our prior publication shows that men with less than 22 CAG repeats of Androgen Receptor (AR) gene, along with 'GG' genotype of Cytochrome P4503A5*3 (CYP3A5*3) gene polymorphism are at a higher risk of developing PCA. These polymorphisms play an important role in the metabolism of testosterone and are involved in the growth and differentiation of prostate lesions [20].…”

Section: Related Workmentioning

confidence: 99%

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Association of Regulatory Factor X 6 gene (rs339331) polymorphism with Prostate Cancer A case-control study from South India

Daram¹,

Poornima²,

Zubeda³

et al. 2019

IJSRBS

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Prostate Cancer (PCA) is a heterogeneous disease which exhibits clinical variability, morphological differences and molecular marker diversity. Currently, Prostate specific antigen (PSA) evaluation is the only clinically relevant non-invasive marker for PCA screening. A number of genome wide association studies (GWAS) have identified many susceptibility markers for PCA, one of which is a single nucleotide polymorphism (SNP) rs339331, in Regulatory Factor X 6 (RFX6) gene. The present study evaluated this polymorphism g.16677T>C of RFX6 gene, in PCA, benign prostate hyperplasia (BPH) and controls by PCR using specifically designed primers, followed by restriction digestion. Results show that the frequency of 'C' allele is 0.74 in PCA and 0.20 in BPH, which is lower than the frequency in controls, which is 0.35. The 'C' allele of RFX6 genotype is significantly associated with PCA (P<0.05). This is the first case-control study from India which shows an association of 'C' allele of RFX6 gene g.16677T>C polymorphism with high risk of developing PCA and a potential to use it as a biomarker for identifying men at risk of developing PCA.

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“…The base line clinical characteristics of the cohort studied have been discussed in our previous publication [20].…”

Section: Results and Discussion Clinical Characteristicsmentioning

confidence: 99%

Section: Related Workmentioning

confidence: 99%

Association of Regulatory Factor X 6 gene (rs339331) polymorphism with Prostate Cancer A case-control study from South India

Daram¹,

Poornima²,

Zubeda³

et al. 2019

IJSRBS

Self Cite

View full text Add to dashboard Cite

show abstract

Association of Androgen Receptor (AR) CAG Repeats and Cytochrome P450 3A53 (CYP3A53) Gene Polymorphisms in South Indian Men with Prostate Cancer

Cited by 1 publication

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Association of Regulatory Factor X 6 gene (rs339331) polymorphism with Prostate Cancer A case-control study from South India

Association of Regulatory Factor X 6 gene (rs339331) polymorphism with Prostate Cancer A case-control study from South India

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