Association of an intronic SNP rs9939609 in FTO gene with type 2 diabetes mellitus among Bangladeshi population: A case–control study combined with updated meta-analysis

Kar, Kumkum; Munim, Md. Adnan; Fariha, Atqiya; Roy, Arpita Singha; Rahman, Md. Imranur; Akter, Shahana; Tonmoy, Mahafujul Islam Quadery; Alam, Mohammad Rahanur; Raunak, Ahmed Ifrad Bin; Selim, Shahjada; Hossain, Md. Murad; Reza, Hasan Al; Bahadur, Newaz Mohammed; Hossain, Md. Shahadat

doi:10.1016/j.humgen.2022.201133

Cited by 6 publications

(6 citation statements)

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“…In this study, the FTO gene of the SNP rs9939609 was analyzed in the normal-weight group and obese Iraqi patients, and the relationship between FTO gene polymorphism with some biochemical markers. The role of the FTO gene in obesity and predicting type II diabetes mellitus was also investigated [15].…”

Section: Discussionmentioning

confidence: 99%

Study the Association of Fat Mass and Obesity-associated (FTO) Gene Polymorphisms (SNP rs9939609) with Biochemical Markers in Obese Iraqi Patients

Hashim,

Sabah,

Abbas

2024

Iraqi Journal of Science

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This study aimed to evaluate the association of single nucleotide polymorphisms (SNP rs-9939609) of the fat mass and obesity-associated (FTO) gene with body mass index (BMI) and some biochemical markers in obese patients. The fat and mass obesity (FTO) gene variant specific single nucleotide polymorphism (SNP rs-9939609) with the T to A missense mutation may have a powerful association with obesity. This case-control study included 106 obese patients (57 males and 49 females) and 80 healthy control (40 males and 40 females). DNA was extracted from whole blood, and then the tetra-primer amplification refractory mutation system - polymerase chain reactions (ARMS.PCR) technique was used to limit the single nucleotide gene polymorphisms (rs9939609) of the FTO gene. Lipid profile, glycated hemoglobin (HbA1C), fasting blood sugar, insulin and FTO concentrations were measured by standard methods. In this study, the A allele in the rs9939609 was at a higher frequency of 35 (33.1%) in the obese patients and at a significant p-value = 0.039 compared with control 15 (18.7%). It significantly increased in the additive model and allele frequency (p= 0.003, 0.002 respectively). The rs9939608 SNP showed a significant association with increased BMI, insulin and homeostatic model assessment-insulin resistance (HOMO-IR) with p-values of 0.001, 0.001 and 0.028 respectively. After making adjustments for age and sex, lower levels of high-density lipoprotein (HDL) were observed in the AA and TA genotypes compared to the TT genotype (p = 0.004). While, no significant differences were recorded between the rs9939608 SNP and HbA1C, total cholesterol (TC), triglyceride (TG), very low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) in obese patients

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Section: Discussionmentioning

confidence: 99%

Study the Association of Fat Mass and Obesity-associated (FTO) Gene Polymorphisms (SNP rs9939609) with Biochemical Markers in Obese Iraqi Patients

Hashim,

Sabah,

Abbas

2024

Iraqi Journal of Science

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“…Genomic DNA was extracted from whole-blood specimens using Blood DNA Prep Plus, following the manufacturer’s protocol (A&A Biotechnology, Gdynia, Poland). FTO gene polymorphisms were assessed using the tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) technique, employing custom-designed oligonucleotide sequences for FTO rs1558902 ( Supplementary Materials Table S2 ) and previously described primers for FTO rs9939609 [ 25 ]. The PCR conditions were as follows: initial denaturation for 5 min at 94 °C; 34 cycles of 50 s at 94 °C, annealing step for 60 s at 61 °C, and 60 s at 72 °C; and final elongation at 72 °C for 5 min.…”

Section: Methodsmentioning

confidence: 99%

Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and FTO Gene Polymorphisms (rs9939609, rs1558902)

Czarnecka,

Purzycka-Bohdan,

Zabłotna

et al. 2024

Biomedicines

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This study aimed to comprehensively analyze the problem of overweight and obesity among psoriatic patients by investigating the influence of body mass composition, anhedonia and depression, environmental factors and FTO gene polymorphisms. Methods: The study enrolled 30 overweight or obese adult patients with chronic plaque psoriasis and 30 overweight or obese volunteers (northern Poland region, Caucasian population). Mood disorders, body mass composition by using bioelectrical impedance analysis (BIA) and FTO gene polymorphisms (rs9939609, rs1558902) by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) were assessed. Results: Results revealed significantly higher visceral adipose tissue levels in psoriatic patients (5.23 ± 2.29 [L] vs. 3.41 ± 1.86 [L]), p = 0.001), especially among men, along with elevated rates of moderate and severe depression (26.67% vs. 6.67% and 13.33% vs. 3.33%, p = 0.048 respectively). Additionally, FTO gene polymorphisms correlated with waist–hip ratio differences in both groups. Conclusions: The study highlights the importance of evaluating body composition beyond body mass index, recognizing its influence on psoriasis and associated conditions like depression. The FTO gene may serve as a potential genetic link between psoriasis and obesity, warranting further research for validation. Adiposity emerges as a key and modifiable risk factor, underscoring the clinical implications of body composition complexities in psoriasis management.

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“…Overall, while the research on FTO polymorphism and obesity in the Bangladeshi population is limited, the available studies suggest a possible association between the FTO gene and obesity in this population 17 . However, Kar et al did not find any association between FTO polymorphism and obesity in Bangladeshi adults 18 . Extensive research with larger sample sizes, as well as more biochemical and behavioral parameter, is needed to better understand about the relationship between FTO polymorphism and obesity in the Bangladeshi population.…”

Section: Introductionmentioning

confidence: 92%

“… 17 However, Kar et al did not find any association between FTO polymorphism and obesity in Bangladeshi adults. 18 Extensive research with larger sample sizes, as well as more biochemical and behavioral parameter, is needed to better understand about the relationship between FTO polymorphism and obesity in the Bangladeshi population.…”

Section: Introductionmentioning

confidence: 99%

Crosstalk between FTO gene polymorphism (rs9939609) and obesity‐related traits among Bangladeshi population

Shill

Alam

2023

Health Science Reports

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Background and Aims: Obesity is a growing public health concern in Bangladesh, which is influenced by a complex interplay of genetic and environmental factors. The genetic variant rs9939609 of the FTO (fat mass and obesity-associated) gene has been found to be associated with an increased risk for obesity, depending on the population studied. The purpose of this cross-sectional study is to examine the relationship between the FTO gene polymorphism (rs9939609) and lifestyle-related risk factors, and their impact on obesity-related traits and biochemical parameters in the Bangladeshi population.Methods: A total of 280 participants were enrolled in this study, comprising of 140 individuals with overweight and obesity (body mass index [BMI] ≥ 23.0) and 140 non-overweight healthy individuals (18.5 ≤ BMI ≥ 22.9). Demographic information, dietary behaviors, and physical activity-related data were collected using a structured questionnaire. Additionally, anthropometric assessments and measurements of biochemical parameters such as lipid profile and C-reactive protein were performed. The amplification refractory mutation system-polymerase chain reaction technique was used to identify single-nucleotide polymorphism in the FTO gene.Descriptive statistics, χ, 2 and one-way ANOVA were performed to evaluate the relationships between independent and dependent variables.Results: The presence of rs9939609 was strongly associated with the obesity risk factors of increased BMI, cholesterol, triglycerides, and low-density lipoprotein. We also found a significant association (p < 0.05) of rs9939609 with overweight and obesity in codominant AA versus TT (odds ratio [OR] = 0.299, 95% CI: 0.129−0.695) and AA versus AT (OR = 2.273, 95% CI: 1.023−5.053), recessive TT versus AA+AT (OR = 5.154, 95% CI: 2.463−10.782), and overdominant AT versus AA+TT (OR = 0.244, 95% CI: 0.122−0.488) models. Conclusion:FTO variant rs9939609 is significantly linked to obesity and an increased risk of hyperlipidemia in the Bangladeshi population. However, this association is intertwined with environmental factors such as diet and physical activity.

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Association of an intronic SNP rs9939609 in FTO gene with type 2 diabetes mellitus among Bangladeshi population: A case–control study combined with updated meta-analysis

Cited by 6 publications

References 66 publications

Study the Association of Fat Mass and Obesity-associated (FTO) Gene Polymorphisms (SNP rs9939609) with Biochemical Markers in Obese Iraqi Patients

Study the Association of Fat Mass and Obesity-associated (FTO) Gene Polymorphisms (SNP rs9939609) with Biochemical Markers in Obese Iraqi Patients

Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and FTO Gene Polymorphisms (rs9939609, rs1558902)

Crosstalk between FTO gene polymorphism (rs9939609) and obesity‐related traits among Bangladeshi population

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