Association of an early respiratory syncytial virus infection and atopic allergy

Juntti, Hanna; Kokkonen, Jorma; Dunder, Teija; Renko, Marjo; Niinimäki, Aila; Uhari, Matti

doi:10.1034/j.1398-9995.2003.00233.x

Cited by 48 publications

(49 citation statements)

References 26 publications

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“…56 -58 Two other articles did not show an association between RSV infection and physician-diagnosed asthma 52,53 : Juntti did not find an association, although in children with asthma the disease appeared significantly sooner in those who had a history of RSV. 52 Finally, Korppi followed-up children with RSV infection and a control group for 20 years, and found that RSV was a risk factor for altered pulmonary function independent of atopia. He concluded that RSV bronchiolitis was not a predisposing factor for the development of asthma and atopia, although it might be a marker for immunologic changes that are common to both disorders.…”

Section: Resultsmentioning

confidence: 98%

The Association Between Respiratory Syncytial Virus Infection and the Development of Childhood Asthma

Pérez-Yarza

Moreno²,

Lázaro³

et al. 2007

Pediatric Infectious Disease Journal

105

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On the basis of this systematic review of the literature, it can be concluded that a significant association exists between RSV infection in childhood and the long-term development of subsequent episodes of recurrent wheezing or asthma. However, the methodologic quality of the articles evaluated is limited, and hence additional studies are needed, ideally, with specific therapeutic interventions aimed at reducing RSV replication.

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Section: Resultsmentioning

confidence: 98%

The Association Between Respiratory Syncytial Virus Infection and the Development of Childhood Asthma

Pérez-Yarza

Moreno²,

Lázaro³

et al. 2007

Pediatric Infectious Disease Journal

105

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“…An early case control study from the US showed an increased risk of bronchiolitis in families with C1 smoker (McConnochie and Roghmann 1960) but several other prospective case-control studies showed a significant effect in univariate analysis (P = 0.018 and 0.0004, respectively) but not in multivariate analysis (Bulkow et al 2002;Sigurs et al 1995;Juntti et al 2003). A large cohort study in Arizona showed no significant effect of environmental tobacco smoke exposure in a multivariate analysis (Holberg et al 1991) while a more recent large nested casecontrol study from the Danish birth cohort (2564 infants and children hospitalized with RSV and 12816 age-matched controls) (Stensballe et al 2006), found an association between tobacco smoke exposure and an increased risk of hospitalization with RSV (odds ratio: 1.35; 95 % confidence interval: 1.20-1.52).…”

Section: Risk Factors For Infection and Diseasementioning

confidence: 96%

Clinical and Epidemiologic Features of Respiratory Syncytial Virus

Hall

Simões

Anderson

2013

Current Topics in Microbiology and Immunology

127

135

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Since its discovery in 1955, respiratory syncytial virus (RSV) has consistently been noted to be the single most important cause of lower respiratory tract illness in infants <1 year of age. RSV also causes repeat infections and significant disease throughout life. In addition to the young child, persons with compromised immune, pulmonary or cardiac systems, and the elderly have significant risk from infection. Though RSV causes the full spectrum of acute respiratory illnesses, it is most notably associated with signs and symptoms of increased airway resistance manifested as wheezing and, in the young child, diagnosed as bronchiolitis. In temperate climates, RSV occurs as yearly outbreaks usually between late fall and early spring lasting 3-4 months in a community. The timing of outbreaks varies between years and in the same year between regions and even between nearby communities. RSV can be a serious nosocomial pathogen in high risk individuals but nosocomial transmission that can often be prevented with meticulous attention to good infection control practices. High risk groups include the premature infants and persons of any age with compromised cardiac, pulmonary, or immune systems. Risk factors for infection include increased number of children in the household and day care center attendance. There are reasonable estimates of the sizable burden of RSV disease in infants and young children and the elderly but less data on disease in older children, the role of RSV in later reactive airway disease (see chapter by M.T. Lotz et al. , this volume), and RSV-associated mortality in developing countries. The available data on burden of disease suggests there are at least four potential target populations for a vaccine, the young infant, young children >4-6 months of age, pregnant women, and the elderly. A link between infection in the young infant and later reactive airway disease and mortality in developing countries is needed. Each target population has different vaccine safety and efficacy concerns and may warrant a different type of vaccine.

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“…RSV is implicated in asthma and allergy, although reports are conflicting with some suggesting that prior RSV infection protects against development of atopy as determined by skin prick test [41] and others suggesting that RSV infection predisposes to the development of allergic conditions such as asthma [42,43]. Serum collected from RSV-infected patients contains elevated Th2 cytokines and IgE [44,45], suggesting that viral infection induces an allergy-like condition.…”

Section: Discussionmentioning

confidence: 99%

DP2 (CRTh2) Antagonism Reduces Ocular Inflammation Induced by Allergen Challenge and Respiratory Syncytial Virus

Stebbins¹,

Broadhead²,

Musiyenko

et al. 2011

Int Arch Allergy Immunol

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Background: Allergic conjunctivitis is characterized by itchy, watery and swollen eyes which occur in response to exposure to seasonal or environmental allergens. The early phase reaction of allergic conjunctivitis is primarily mediated by mast cell degranulation while the late phase reaction is driven by Th2 cells and eosinophils. Prostaglandin D₂ (PGD₂), released from mast cells, is present in allergic conjunctival tears and may elicit classical allergic responses via interaction with the high-affinity DP2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells, CRTh2). Furthermore, antagonism of this receptor is well known to inhibit eosinophil chemotaxis, basophil activation and Th2 cytokine production. PGD₂, therefore, may be involved in both early and late phase reactions in response to allergen challenge. Methods: Thus, we explored whether our novel and selective DP2 antagonist AM156 would be efficacious in animal models of allergic conjunctivitis. Furthermore, as respiratory syncytial virus (RSV) has been implicated in the pathogenesis of allergic conjunctivitis, we examined the effects of DP2 antagonism in a murine model of RSV ocular infection. Results: Utilizing a guinea pig ovalbumin model and a murine ragweed model we demonstrated that AM156 reduces redness, discharge and swelling in response to allergen challenge. These effects were equal to or greater than those of current clinical treatment options for allergic conjunctivitis including topical corticosteroids and a dual-mechanism antihistamine and decongestant. AM156 significantly reduced RSV-induced ocular inflammation and IL-4 production. Conclusion: These results suggest that a topical DP2 antagonist such as AM156 may represent a novel therapeutic for allergic conjunctivitis.

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Association of an early respiratory syncytial virus infection and atopic allergy

Abstract: An early RSV infection results in reduction of SPT positivity but not of occurrence of atopic diseases. This finding might explain why there is less atopic sensitization in countries with a greater probability of acquiring RSV infection at an early age.

Cited by 48 publications

References 26 publications

The Association Between Respiratory Syncytial Virus Infection and the Development of Childhood Asthma

The Association Between Respiratory Syncytial Virus Infection and the Development of Childhood Asthma

Clinical and Epidemiologic Features of Respiratory Syncytial Virus

DP2 (CRTh2) Antagonism Reduces Ocular Inflammation Induced by Allergen Challenge and Respiratory Syncytial Virus

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