Association of an Abnormal Exercise Heart Rate Recovery With Pulmonary Function Abnormalities

Seshadri, Niranjan; Gildea, Thomas R.; McCarthy, Kevin; Pothier, Claire E.; Kavuru, Mani S.; Lauer, Michael S.

doi:10.1378/chest.125.4.1286

Cited by 39 publications

(49 citation statements)

References 23 publications

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“…However, the literature is scares regarding the relationship between HRR after the 6MWT and prognosis in patients with chronic obstructive pulmonary disease (COPD) (4)(5). In chronic respiratory entities, abnormal autonomic cardiac response could be consequence of a lower parasympathetic activation and/or increased sympathetic tone, being widely accepted that parasympathetic activations plays a protective role (6)…”

Section: Introductionmentioning

confidence: 99%

Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD

Rodríguez

Kortianou

Alison

et al. 2017

Lung

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Section: Introductionmentioning

confidence: 99%

Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD

Rodríguez

Kortianou

Alison

et al. 2017

Lung

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“…Lacasse ve ark.ları (21) bisiklet ergometresi testi sonrası KOAH'lı hastalardaki anormal KH toparlanması oranının %66 olduğunu; Seshadri ve ark.ları (24) ise solunum fonksiyon testi anormallikleri olan olgularda, koşu bandı sonrası %36 oranında anormal KH toparlanması olduğunu belirledi. Çalışmamızdaki olguların FEV 1 değerleri, Lacasse ve ark.nın (21) çalışmadaki değerlere benzer olduğundan, anormal KH toparlanma sıklığının bizim çalışmamız-da daha düşük olması, bisiklet ergometresinde oluşan kardiyovasküler zorlanmanın, koşu bandındakinden daha az olmasından ve bizim çalışmamızdaki olguların daha genç olmasından kaynaklanmış olabilir.…”

Section: Kalp Hızı Toparlanmasıunclassified

“…Kalp hızı toparlanmasındaki değişimin %49'unu, FEV 1 ve FVC, bağımsız olarak açıkladı. Literatürde KOAH'lı hastalarda düşük FEV 1 düzeyinin, anormal KH toparlanması cevabı ile birlikte olduğu gösterilmiştir (21,24). Bizim çalışmamızda FEV 1 ve KH toparlanması arasında orta düzeyde anlamlı bir ilişki olduğu saptandı.…”

Section: Kalp Hızı Toparlanmasıunclassified

“…Seshadri ve ark.ları (24) solunum fonksiyon testinde bozukluk olan olgularda, ileri yaş, yüksek istirahat KH, erkek olmak, düşük fonksiyonel kapasite, düşük FEV 1 ve sigara içiminin, anormal KH toparlanmasını tahmin ettiğini gösterdi. Kalp hızı toparlanması vagal reaktivasyonla sağlanır; KH'nın azalma hızı, egzersiz sırasında gerekli olan sempatik modülasyondan daha hızlı toparlanmayı yansıtır (41).…”

Section: Kalp Hızı Toparlanmasıunclassified

“…Parasempatik fonksiyonun değerlendirildiği çalışmalarda (19)(20)(21)(22)(23), egzersiz (20) veya postüral değişiklikleri (19,22) sırasında KH değişkenliğinin azaldığı (19,20,22) ve maksimal bisiklet ergometresi efor testi sonrası, KH toparlanmasının geciktiği (21,23) belirlenmiştir. Kronotropik indeksin ise, bir çalışmada incelendiği ve sonuçların obstrüksiyonu olmayan hastaların değerleri ile birlikte rapor edildiği görülmektedir (24).…”

Section: Introductionunclassified

See 2 more Smart Citations

Cardiac autonomic responses to exercise testing in patients with chronic obstructive pulmonary disease

İnce¹,

Savcı²,

Arıkan³

et al. 2010

Anadolu Kardiyol Derg

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Kronik obstrüktif akciğer hastalarında egzersiz testine kardiyak otonom yanıtlarCardiac autonomic responses to exercise testing in patients with chronic obstructive pulmonary disease 104 ABSTRACT Objective: Incremental exercise testing is used to evaluate exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). The purpose of this cross-sectional, observational study was to compare cardiac autonomic responses of patients to exercise testing with healthy subjects and to investigate their determinants. Methods: Twenty-five COPD patients and 20 healthy subjects participated in the study. Pulmonary function test, arterial blood gas analysis and exercise test were performed. Heart rate, blood pressure and dyspnea were measured before and after the test. Peak oxygen uptake, chronotropic index and heart rate recovery were recorded. Dyspnea perception during daily activities was measured using the modified Medical Research Council dyspnea scale. Student t test, Mann Whitney u test, Spearman correlation coefficients and multiple linear regression analysis were used for statistical analysis.Results: Peak heart rate, chronotropic index and peak oxygen uptake were significantly lower and exercise dyspnea perception was significantly higher in COPD patients than those of healthy subjects (p<0.05). Forty-eight percent of patients had chronotropic incompetence. Body weight and body mass index of these patients were significantly higher than in those with normal chronotropic response (p<0.05). Baseline, peak and recovery heart rate were significantly lower in patients with chronotropic incompetence (p<0.05

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Hemodynamic response, arrhythmic risk, and overall safety of Regadenoson as a pharmacologic stress agent for myocardial perfusion imaging in chronic obstructive pulmonary disease and bronchial asthma patients

Husain

Palani

Cabrera

et al. 2011

Int J Cardiovasc Imaging

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Regadenoson (REG) is a A2a receptor selective pharmacologic SPECT imaging agent. Its safety in unselected chronic obstructive pulmonary disease (COPD) or asthma (AM) undergoing SPECT imaging has not been well evaluated. We retrospectively identified 228 patients (COPD n = 126 and AM n = 102, Grp 1) undergoing REG SPECT from Jan to Nov 2009 and compared to 1,142 patients without COPD and AM (control, Grp 2). A standard 400 μg REG bolus was used and gated Tc-99 m tetrofosmin SPECT done. Patient demographics, REG SPECT data, side effects, arrhythmia occurrences, and any exacerbation of COPD or AM leading to treatment, hospitalization or death were evaluated. The side effect profile of Grp 1 was also compared to a historical cohort who underwent intravenous dipyridamole thallium-201 imaging and adenosine SPECT. Both groups were comparable with regards to baseline characteristics. There was 0% incidence of clinical exacerbation of COPD or AM after REG. COPD patients had more non-significant arrhythmias (58.3% vs. Grp 2, 43%, P = 0.004). There was 0% incidence of any atrio-ventricular block and only 2 instances of brief supraventricular tachycardia. When compared to the historical cohort of COPD who underwent IV dipyridamole thallium imaging, COPD in Grp 1, had more dyspnea and flushing and when compared to COPD/AM patients who underwent adenosine SPECT, Grp 1 pts had more of flushing and headache (24.9% vs. 2.8%, P = <0.001) but less of bronchospasm (1.3% vs. 6.9%, P = 0.022) and AV block (0% vs. 4.2%, P = 0.014). REG SPECT can be safely performed in COPD and AM population.

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Association of an Abnormal Exercise Heart Rate Recovery With Pulmonary Function Abnormalities

Cited by 39 publications

References 23 publications

Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD

Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD

Cardiac autonomic responses to exercise testing in patients with chronic obstructive pulmonary disease

Hemodynamic response, arrhythmic risk, and overall safety of Regadenoson as a pharmacologic stress agent for myocardial perfusion imaging in chronic obstructive pulmonary disease and bronchial asthma patients

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