Association of Ambient Air Pollution With Presence of Respiratory Symptoms Among Children With Asthma

Lewis, Toby; Robins, Thomas; Mentz, Graciela; Yip, Fuyuen; Dvonch, J. Timothy; Keeler, Gerald J.; Ramirez, Erminia; Parker, Edith A.; Israel, Barbara A.

doi:10.1097/00001648-200407000-00081

Cited by 1 publication

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“…[22][23][24][25][26][27][28][29] Studies of the impact of ambient pollution on asthma symptoms and lung function have also been inconsistent, with some studies finding air pollution results in poor asthma outcomes, [30][31][32] others finding no impact, 33,34 and others finding associations only for specific subgroups of children. 35,36 One explanation for these conflicting results is exposure misclassification or measurement error due to using community ambient air quality monitoring sites to assess an individual's exposure level. 37,38 Children spend a majority of their time indoors 39 , and there can be large differences between indoor and outdoor levels of air pollutants.…”

Section: Introductionmentioning

confidence: 99%

Breathing zone pollutant levels are associated with asthma exacerbations in high-risk children

Moore,

Thornburg,

Secor

et al. 2023

Preprint

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Background: Indoor and outdoor air pollution levels are associated with poor asthma outcomes in children. However, few studies have evaluated whether breathing zone pollutant levels associate with asthma outcomes. Objective: Determine breathing zone exposure levels of NO2, O3, total PM10 and PM10 constituents among children with exacerbation-prone asthma, and examine correspondence with in-home and community measurements and associations with outcomes. Methods: We assessed children's personal breathing zone exposures using wearable monitors. Personal exposures were compared to in-home and community measurements and tested for association with lung function, asthma control, and asthma exacerbations. Results: 81 children completed 219 monitoring sessions. Correlations between personal and community levels of PM10, NO2, and O3 were poor, whereas personal PM10 and NO2 levels correlated with in-home measurements. However, in-home monitoring underdetected brown carbon (Personal:79%, Home:36.8%) and ETS (Personal:83.7%, Home:4.1%) personal exposures, and detected black carbon in participants without these personal exposures (Personal: 26.5%, Home: 96%). Personal exposures were not associated with lung function or asthma control. Children experiencing an asthma exacerbation within 60 days of personal exposure monitoring had 1.98, 2.21 and 2.04 times higher brown carbon (p<0.001), ETS (p=0.007), and endotoxin (p=0.012), respectively. These outcomes were not associated with community or in-home exposure levels. Conclusions: Monitoring pollutant levels in the breathing zone is essential to understand how exposures influence asthma outcomes, as agreement between personal and in-home monitors is limited. Inhaled exposure to PM10 constituents modifies asthma exacerbation risk, suggesting efforts to limit these exposures among high-risk children may decrease their asthma burden.

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