Association of alopecia areata with hospitalization for mental health disorders in US adults

Singam, Vivek; Patel, Kevin R.; Lee, Harrison H.; Rastogi, Shipra; Silverberg, Jonathan I.

doi:10.1016/j.jaad.2018.07.044

Cited by 32 publications

(37 citation statements)

References 4 publications

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“…Finally, other inflammatory skin diseases, e.g. alopecia areata (AA), were previously found to be associated with MH comorbidities [6]. Though, little is known about how the MH comorbidities of psoriasis compared with other skin diseases.…”

Section: Introductionmentioning

confidence: 99%

Association of Psoriasis with Psychiatric Hospitalization in United States Children and Adults

et al. 2019

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Background: Psoriasis is associated with psychosocial distress. Little is known about the relationship between psoriasis and mental health (MH) emergencies. Objective: To examine the associations of psoriasis and MH hospitalizations in the USA. Methods: Data from the 2002–2012 National Inpatient Sample were analyzed, including an approximately 20% sample of all US hospitalizations (n = 87,053,155 children and adults). Results: Hospitalization for MH disorders occurred more commonly in those with psoriasis compared to those without psoriasis (4.04 vs. 2.21%). In multivariable logistic regression models, psoriasis was associated with higher odds of admission for any MH disorder overall (adjusted odds ratio [95% confidence interval]: 2.32 [2.24–2.41]), as well as 9 of the 15 MH-specific disorders examined. Associated MH disorders included: anxiety, schizophrenia, personality disorder, depression, substance use disorders, history of MH disorder, alcohol-related disorders, adjustment disorders, and cognitive disorders. Children with versus those without psoriasis were also more likely to have a primary hospitalization for any MH disorder (2.82 [2.24–3.56]). Psoriasis inpatients were also more likely to have a primary hospitalization for any MH disorder compared to those with alopecia areata (1.99 [1.45–2.74]) or hidradenitis suppurativa (3.97 [3.49–4.52]). Psoriasis patients hospitalized with any MH disorder had higher mean [95% confidence interval] cost of inpatient care (USD 11,004 [10,846–11,241] vs. 9,547 [8,730–10,364]; p < 0.0001) compared to those without psoriasis, with USD 1,610,860 excess costs annually, with the majority of the costs coming from depression and mood disorders. Conclusions: Children and adults with psoriasis had increased hospitalization for multiple MH disorders, which were associated with a considerable financial burden.

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Section: Introductionmentioning

confidence: 99%

Association of Psoriasis with Psychiatric Hospitalization in United States Children and Adults

et al. 2019

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“…In a recent cross-sectional study using a US national database of hospitalizations, patients with alopecia areata were found to have higher rates of schizophrenia compared to controls [61]. An earlier study using a Danish cohort found a higher lifetime prevalence of alopecia areata among schizophrenic patients [15].…”

Section: Resultsmentioning

confidence: 99%

A Review of Skin Disease in Schizophrenia

2020

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Background: Schizophrenia is a debilitating neuropsychiatric condition that affects 0.5% of the North American population. Skin disease in schizophrenia has not been well described. Identifying skin diseases that are commonly comorbid with schizophrenia may help clinicians address the burden of skin disease in patients with schizophrenia. Summary: We conducted a nonsystematic review of the literature to identify skin diseases that may be associated with schizophrenia. We searched MEDLINE, EMBASE, and PsycINFO for articles published in English from December 2000 through April 2020 using the key words “skin disease” or “dermatological” or “dermatology” and “schizophrenia.” Based on our results, we further refined the search terms to include more specific skin diseases. Schizophrenia appears to be associated with a number of skin diseases, including inflammatory dermatoses, autoimmune diseases, and certain genodermatoses. Limitations include being a nonsystematic review and the relative paucity of more rigorous clinical research using longitudinal study designs.

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“…To the Editor: I read with great interest the article on the association between alopecia areata (AA) and mental health disorders by Singam et al 1 Among several conditions evaluated in their study, schizophrenia, attention-deficit disorder, and conduct disorders were positively associated with AA, different from findings of a previous report. 2 I have 2 comments regarding the disagreement between these 2 studies.…”

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confidence: 75%

“…Also, the risk of attention-deficit disorder and personality disorder were not reduced in patients with AA. 2 I speculate that the severity of disorders contributes to the association because Singam et al 1 reported some discrepancies with the association by selecting primary or secondary diagnosis or primary hospitalization as independent variables. Although the authors handled a great number of samples, the characteristics of each variable would influence the association.…”

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confidence: 99%

Comment on “Association of alopecia areata with hospitalization for mental health disorders in US adults”

Kawada

2019

Journal of the American Academy of Dermatology

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Association of alopecia areata with hospitalization for mental health disorders in US adults

Cited by 32 publications

References 4 publications

Association of Psoriasis with Psychiatric Hospitalization in United States Children and Adults

Association of Psoriasis with Psychiatric Hospitalization in United States Children and Adults

A Review of Skin Disease in Schizophrenia

Comment on “Association of alopecia areata with hospitalization for mental health disorders in US adults”

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