Association of allergic diseases with children’s life satisfaction: population-based study in Finland

Haanpää, Leena; Ursin, Piia af; Nermes, Merja; Kaljonen, Anne; Isolauri, Erika

doi:10.1136/bmjopen-2017-019281

Cited by 18 publications

(16 citation statements)

References 40 publications

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“…The patients were divided into three subgroups according to the level of asthma: controlled, partly controlled, and uncontrolled asthma. Allergic rhinitis was diagnosed and classified (as seasonal or perennial, and mild, moderate, or severe, and allergic or non-allergic) according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines [14]. Atopic dermatitis was diagnosed according to the Hanifin and Rajka criteria based on patient history and clinical characteristics [19].…”

Section: Methodsmentioning

confidence: 99%

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Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases

et al. 2019

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Background Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-γ) stimulation. We investigated neopterin, tryptophan, and kynurenine levels as biomarkersof the Th1 immune system activation and changes in IDO-1 activityin children with asthma, allergic rhinitis, and atopic dermatitis, as well as the relationship between these biomarkers and the total IgE level, age, and disease severity. Methods We divided 205 children (80 girls and 125 boys, four months to 17 years old) into four groups: controls, patients with asthma, patients with allergic rhinitis, and patients with atopic dermatitis. Peripheral venous blood samples were collected. Neopterin levels were determined by an enzyme immunoassay. Tryptophan and kynurenine levels were analyzed using HPLC. IDO-1 enzyme activity was calculated using tryptophan and kynurenine levels. IgE levels were measured. The Mann-Whitney U test, Kruskal-Wallis test, and Conover post-hoc method were used for statistical analysis. Results Neopterin, tryptophan, and kynurenine levels were higher and IgE levels and IDO-1 enzyme activity were lower in patients with asthma and allergic rhinitis than in controls ( P <0.05). Patients with atopic dermatitis showed higher neopterin, tryptophan, and kynurenine levels, higher IDO-1 activity, and lower IgE levels thancontrols ( P <0.05). Conclusions The Th1/Th2 balance is disrupted in children with allergic diseases, concomitant with increased Th1-mediated immune response activation and reduced IgEproduction, which is promoted by Th2-type cytokines.

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Section: Methodsmentioning

confidence: 99%

“…Allergic diseases, one of the most common chronic conditions in childhood, include allergic rhinitis, asthma, dermatitis, conjunctivitis, anaphylaxis, and food and drug allergies, and affect approximately one in five people globally [12]. Allergies are immune reactions that affect various tissues and organs in many diseases [3].…”

Section: Introductionmentioning

confidence: 99%

Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases

et al. 2019

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“…& Local area: Feeling safe, access to resources and social connectedness have been found to positively relate to subjective well-being (Eriksson et al 2011;Oberle et al 2011;Kaye-Tzadok et al 2017;Lee and Yoo 2015;Newland et al 2015;Lawler et al 2017;Newland et al 2018). & Health: Several health-related factors including physical fitness (positive association) and illness or disease (negative association) have been found to relate to children's LS (Marques et al 2017;Klocke et al 2014;Kleszczewska et al 2018;Haanpää et al 2018;Lew et al 2018). & Time use (including ICT use): Time use, particularly in relation to ICT use, has been found to predict variation in LS, and also varies according to gender, thus potentially explaining gender differences in LS (Rees 2017;Larson and Verma 1999;Amin and Chandrasekhar 2012;Ersado 2005;Dornan and Woodhead 2015;Iannotti et al 2009;Fergusson et al 2015;Boniel-Nissim et al 2015) & Rights: Children's awareness of their rights as children and, especially, perceiving that these rights are respected by adults are positively associated with SWB (Casas et al 2018).…”

Section: Other Factorsmentioning

confidence: 99%

Can Schools and Education Policy Make Children Happier? A Comparative Study in 33 Countries

Marquez

Main

2020

Child Ind Res

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Our understanding of child subjective well-being and how to promote it has improved substantially over the last decade. In relation to the role of education policy in shaping subjective well-being, although valuable research has been conducted, many questions remain unanswered. This paper aims to fill this gap by studying the links between education policy and students' life satisfaction. We use linear and multilevel regression to analyse PISA 2015 data on 15-year-old students in 33 countries. Our interest is in within society differences and how these vary across societies. We find that (1) there is an association between multiple education policy-relevant factors and students' life satisfaction, which is particularly prominent-and observed in a larger number of countries-in the domains of family relationships, schoolwork-related anxiety and bullying. Our models explain between one-fifth and one-third of the variation in students' life satisfaction. Results also indicate that (2) schools may play an important role in shaping students' life satisfaction. This is supported by evidence that these associations tend to vary by school; by evidence on the existence of school effects in all countries but two; and by the finding that a proportion-substantial in some countriesof the variation in students' life satisfaction is explained by differences between schools. Finally, we find that (3) in relation to both questions, there are important differences across societies. Overall, these results provide evidence that an association between education policy and children's subjective well-being seems to exist but is of a complex nature.

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“…The prevalence of AR shows an increasing trend worldwide, especially among school-aged children [1,2]. Active allergic disease reduces children’s quality of life [3,4], and imposes a considerable socioeconomic burden [4,5]. Therefore, it is of interest to determine whether AR in a specific child will deteriorate or develop into asthma or other allergic diseases; moreover, caregivers require counseling regarding how their children’s diseases are likely to change over time.…”

Section: Introductionmentioning

confidence: 99%

Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization

et al. 2019

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IntroductionIt is difficult to accurately predict the natural course of allergic rhinitis (AR), because it is affected by a wide variety of environmental influences, as well as genetic predisposition. Considering the high prevalence of allergic rhinitis in children and adolescents, caregivers should be given appropriate information regarding the disease course. This study aimed to understand the prognosis of allergic rhinitis by examining the relationship between allergic sensitization and rhinitis symptoms during this developmental period.MethodsThis cross-sectional study included 1069 children aged 9–16 years from the Korean International Study of Asthma and Allergies in Childhood Survey database who had completed health questionnaires, and for whom skin prick test results were available. Data were collected during May 2016. The distribution of sensitization and allergic symptoms was compared by age groups (elementary, middle, and high school). Data were analyzed using linear-by-linear analysis.ResultsSensitization to at least one tested allergen differed by age (59.2%, 58.3%, 68.2%, in elementary, middle, and high school students, respectively; p = 0.025), and seasonal allergen sensitization (35.0%, 37.1%, 53.9%, respectively) increased with age (p < 0.001). Conversely, the proportion of rhinitis symptoms among sensitized children decreased as age increased (58.80%, 52.90%, 49.70%, respectively; p = 0.047). However, the rate of non-allergic rhinitis was age-independent.ConclusionWith increasing age during childhood and adolescence, symptomatic allergic rhinitis decreases; thus, subclinical allergic rhinitis increases. This suggests that the symptoms of later-sensitized children are less clearly manifested, or that the symptoms reduce as previously sensitized children mature. This should be clarified further in a longitudinal study.

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Association of allergic diseases with children’s life satisfaction: population-based study in Finland

Cited by 18 publications

References 40 publications

Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases

Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases

Can Schools and Education Policy Make Children Happier? A Comparative Study in 33 Countries

Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization

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