Association of Allelic Gene Polymorphisms of Matrix Gla-Protein System with Ischemic Atherothrombotic Stroke

Harbuzova, V. Yu.; Stroy, Dmitriy A; Dosenko, Viktor Е.; Dubovyk, Yevheniy I.; Borodenko, Anastasia O.; Shimko, Kristen; Obukhova, Olga A.; Атаман, Олександр Васильович

doi:10.1615/intjphyspathophys.v7.i1.30

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“…This study aimed to examine the four major VDR polymorphisms: ApaI, TaqI, BsmI, and FokI, plasma concentrations of 25-hydroxy metabolites, and occurrence of such conditions as hypertension, diabetes, obesity, hypercholesterolemia in Polish patients with CVD. Allele frequencies observed in the studied Polish population were similar to those reported by Harbuzova et al [38] and Ortlepp et al [17] in Ukrainian and German patients. In addition, frequencies of VDR polymorphisms were compared with healthy volunteers in Poland [37] and similar results were observed.…”

Section: Discussionsupporting

confidence: 89%

Vitamin D Receptor Gene Polymorphism and Vitamin D Status in Population of Patients with Cardiovascular Disease—A Preliminary Study

et al. 2021

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The association between vitamin D receptor (VDR) polymorphism and the risk of cardiovascular diseases (CVD) remains unclear. This study aimed to assess a relationship between the VDR genotypes, plasma concentrations of vitamin D metabolites, and the occurrence of cardiovascular and metabolic disorders. Fifty-eight patients treated for various cardiological afflictions were included. Identification of VDR polymorphisms: ApaI, TaqI, BsmI, and FokI were carried out using the PCR-RFLP method. Plasma concentrations of 25-hydroxyvitamin-D2, 25-hydroxyvitamin-D3, and 3-epi-25-hydroxyvitamin D3 were assessed by the UPLC-MS/MS method. Lower incidence of BsmI AA genotype in the studied patients was observed compared with healthy controls, but the difference was insignificant. Among patients with the TT genotype, frequency of hypertension was higher than among carriers of other ApaI genotypes (p < 0.01). In addition, carriers of the TT ApaI, TC TaqI, and GA BsmI genotypes had an increased risk of obesity, while the presence of the FokI TT genotype was associated with a higher incidence of heart failure and hypertension. In conclusion, the BsmI AA genotype can be protective against CVD, but this observation needs study on a larger group of patients. Particular VDR genotypes were associated with 25-hydroxyvitamin-D levels, and the mechanism of this association should be further investigated.

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Section: Discussionsupporting

confidence: 89%