Association of alcohol consumption with coronary artery disease severity

Chagas, Patrícia; Mazocco, Letícia; Piccoli, Jacqueline da Costa Escobar; Ardenghi, Thiago Machado; Badimon, Lina; Caramori, Paulo; Pellanda, Lúcia C.; Gomes, Irênio; Schwanke, Carla Helena Augustin

doi:10.1016/j.clnu.2016.06.017

Cited by 17 publications

(22 citation statements)

References 24 publications

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“…Previous studies have revealed an association of alcohol consumption and cardiovascular disease (CVD) and related traits, including blood pressure (BP) and hypertension, but causation has not been definitively established. Additionally, some observational studies have reported J-shaped curves in the relationship between alcohol use and CVD, where light-to-moderate alcohol use is cardio-protective 2 , 3 . However, observational studies are subject to bias due to confounding and reverse causality.…”

Section: Introductionmentioning

confidence: 99%

Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans

Cho

Kwak

Lewis

et al. 2018

Sci Rep

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Previous studies have indicated an association of higher alcohol intake with cardiovascular disease and related traits, but causation has not been definitively established. In this study, the causal effect of alcohol intake on hypertension in 2,011 men and women from the Ansan-Ansung cohort was estimated using an instrumental variable (IV) approach, with both a phenotypic and genotypic instrument for alcohol intake: alcohol flushing and the rs671 genotype (in the alcohol dehydrogenase 2 [ALDH2] gene), respectively. Both alcohol flushing and the rs671 genotype were associated with alcohol intake (difference in alcohol intake with alcohol flushers vs. non-flushers: −9.07 g/day; 95% confidence interval [CI]: −11.12, −7.02; P-value: 8.3 × 10−18 and with the rs671 GA + AA vs. GG genotype: −7.94 g/day; 95% CI: −10.20, −5.69; P-value: 6.1 × 10−12). An increase in alcohol intake, as predicted by both the absence of alcohol flushing and the presence of the rs671 GG genotype in the IV analyses, was associated with an increase in blood pressure in men from this Korean population. In conclusion, this study supports a causal effect of alcohol intake on hypertension and indicated that alcohol flushing may be a valid proxy for the ALDH2 rs671 polymorphism, which influences alcohol intake in this Korean population.

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Section: Introductionmentioning

confidence: 99%

Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans

Cho

Kwak

Lewis

et al. 2018

Sci Rep

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show abstract

“…These results are in agreement with other studies reporting the differential effects of age on the association of gene polymorphisms with cardiovascular disease [ 32–34 ]. Previous studies have reported the associations between alcohol intake and CAD [ 35–37 ]. In the present study, the association between rs6458155 polymorphism and CAD risk was more pronounced in non-drinking individuals.…”

Section: Discussionmentioning

confidence: 99%

Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population

et al. 2018

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Endothelin-1 (ET-1) plays important roles in endothelial dysfunction, vascular physiology, inflammation, and atherosclerosis. Nonetheless, the role of ET-1 (EDN1) gene variants on coronary artery disease (CAD) risk remains poorly understood. The aim of the present study was to evaluate the role of EDN1 gene polymorphisms on individual susceptibility to CAD. We genotyped five tagSNPs (single-nucleotide polymorphisms) (rs6458155, rs4145451, rs9369217, rs3087459, and rs2070699) within EDN1 gene in 525 CAD patients and 675 control subjects. In a multivariate logistic regression analysis, we detected an association of rs6458155 in EDN1 gene with the CAD risk; compared with the TT homozygotes, the CT heterozygotes (odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.02–2.29, P=0.040) and the CC homozygotes (OR = 1.55, 95% CI = 1.01–2.36, P=0.043) were statistically significantly associated with the increased risk for CAD. A similar trend of the association was found in dominant model (OR = 1.53, 95% CI = 1.05–2.25, P=0.029). Consistently, the haplotype rs6458155C-rs4145451C containing rs6458155 C allele exhibited the increased CAD risk (OR = 1.22, 95% CI = 1.03–1.43, and P=0.018). In addition, CT genotype of rs6458155 conferred the increased plasma ET-1 levels compared with TT genotype (P<0.05). No association of the other four tagSNPs in EDN1 gene with CAD risk was observed. In conclusion, our study provides the first evidence that EDN1 tagSNP rs6458155 is associated with CAD risk in the Chinese Han population, which is probably due to the influence of the circulating ET-1 levels.

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“…Alcohol (ethanol) consumption in mild to moderate doses is generally considered to be cardioprotective, while in high doses, the opposite is true. 7,[193][194][195][196][197] This is quite alarming since the current 1 year prevalence of alcohol use disorder in the US population over 18 years is 10% in women and 18% in men. Of these about one-half are moderate or heavy drinkers.…”

Section: Ethanolmentioning

confidence: 99%

Comprehensive review of cardiovascular toxicity of drugs and related agents

Mladěnka

Applová

Patočka

et al. 2018

Medicinal Research Reviews

193

120

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Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta‐blockers, calcium channel blockers, female hormones, nonsteroidal anti‐inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.

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Association of alcohol consumption with coronary artery disease severity

Cited by 17 publications

References 24 publications

Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans

Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans

Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population

Comprehensive review of cardiovascular toxicity of drugs and related agents

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