Association of Alcohol Consumption with Increase in Aortic Stiffness. A 9-Year Longitudinal Study in Middle-Aged Japanese Men.

Nakanishi, Noriyuki; Kawashimo, Haruhito; Nakamura, Koji; Suzuki, Kenji; Yoshida, Hiroshi; Uzura, Sachiko; Tatara, Kozo

doi:10.2486/indhealth.39.24

Cited by 32 publications

(32 citation statements)

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“…Namekata et al reported that alcohol intake and PWV were not related in men (12). In contrast, Nakanishi et al reported that excessive alcohol intake was associated with a risk of increased PWV in a prospective study (13). Mahmud and Feely demonstrated that while excessive alcohol intake increased the PWV in men, the increase was not significant when corrected for blood pressure (14).…”

Section: Discussionmentioning

confidence: 93%

Excessive Alcohol Intake Increases the Risk of Arterial Stiffening in Men with Normal Blood Pressure

Kurihara¹,

Tomiyama²,

Hashimoto

et al. 2004

Hypertens Res

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Excessive alcohol intake is a known atherosclerotic cardiovascular risk factor. However, the relation between excessive alcohol intake and atherosclerotic cardiovascular risk in subjects with normal blood pressure has not been fully elucidated. This cross-sectional study investigated the relationship between alcohol intake and arterial stiffness, as assessed using brachial-ankle pulse wave velocity, in men with normal blood pressure. Middle-aged male workers who were found to have a normal blood pressure during an annual health check-up performed in May-July 2000 (n 1,682) were enrolled in the study. The subjects' laboratory data were analyzed, and information on drinking and smoking habits was obtained by a self-administered questionnaire. The brachial-ankle pulse wave velocity was measured using volume plethysmography. The tween excessive alcohol intake and a marker capable of predicting future atherosclerotic cardiovascular events may provide some information about this inconclusive matter. Pulse wave velocity (PWV), which is a measure of arterial stiffness, has been demonstrated to be a clinical predictor of atherosclerotic cardiovascular disease and cardiovascular disease-related mortality that is independent of other conventional atherosclerotic risk factors (6)(7)(8).In the present study, the PWV was measured in a cohort of men with normal blood pressure, and the relation between alcohol intake and PWV was examined after controlling for conventional atherosclerotic risk factors.

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Section: Discussionmentioning

confidence: 93%

Excessive Alcohol Intake Increases the Risk of Arterial Stiffening in Men with Normal Blood Pressure

Kurihara¹,

Tomiyama²,

Hashimoto

et al. 2004

Hypertens Res

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“…A cross-sectional study in Japanese-American men and women reported that the risk for high aortic PWV was lower among current drinkers and ex-drinkers than among non-drinkers [26]. In a follow-up study in middle-aged Japanese men the incidence of aortic stiffness was not related to alcohol intake [27], whereas another longitudinal study in Japanese men from the same group of investigators suggested that alcohol is an important risk factor for development of aortic stiffness at an intake of more than 16 glasses of alcoholic beverage per week [28]. We recently showed an inverse association between alcohol consumption and aortic PWV in a cross-sectional study among postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and arterial stiffness in men

Sierksma

Muller

Schouw

et al. 2004

Journal of Hypertension

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Objective Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between alcohol intake and aortic stiffness.Design A cross-sectional study.Setting The male population of Utrecht.Participants Of 370 men, aged 40-80 years, alcohol intake was calculated from a standardized questionnaire and aortic stiffness was non-invasively assessed by pulsewave velocity (PWV) measurement of the aorta.Results There were no non-drinkers; therefore the group consuming 0-3 glasses of alcoholic beverage per week was chosen as the reference group in the analyses. Those drinking 4-10, 11-21 and 22-58 glasses of alcoholic beverage per week had a 20.77 m/s (95% confidence interval, 21.26 to 20.28), 20.57 m/s (95% confidence interval, 21.07 to 20.08) and 20.14 m/s (95% confidence interval, 20.65 to 0.36) difference in mean PWV compared with those drinking 0-3 glasses per week. Adjustment for factors that correlated with PWV or alcohol consumption did not change the strength of the association.Conclusion Among men aged 40-80 years there is a J-shaped association between alcohol consumption and PWV. This further supports a decreased risk of cardiovascular disease with moderate alcohol consumption.

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“…As discussed in an accompanying editorial, 16 the findings are not easy to reconcile with the association of alcohol with isolated systolic hypertension 6 nor with a 9-year longitudinal study showing an association between alcohol consumption and increased aortic stiffness in middle-aged Japanese men who were initially free of aortic stiffness. 17 …”

Section: Effects On Large Vessel Structure and Functionmentioning

confidence: 99%

Alcohol and Hypertension

2006

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G iven the social significance of alcohol worldwide it is not surprising that there is continuing strong interest in the relation between alcohol and hypertension. Recent research continues to address unresolved questions concerning the balance between the medical hazards and the cardiovascular benefits of alcohol, the possible significance of different types of beverage, the role of different drinking patterns for cardiovascular morbidity and mortality, and mechanisms underlying the pressor effects of ethanol. These issues all need to be considered in the context of social aspects of drinking and effects on noncardiovascular morbidity and mortality. Epidemiologic data relating the type or quantity of alcohol consumption to blood pressure or cardiovascular disease needs to be viewed with circumspection from a number of viewpoints. First, heavier drinkers or problems drinkers are far less likely to participate in surveys than others. Second, alcohol consumption past or present is notoriously underreported. Third, drinking patterns are difficult to quantify and often not reported at all. The type, quantity, and pattern of drinking are all highly correlated with socioeconomic and other lifestyle behaviors, 1 many of which may not be measured or not measured accurately enough for adequate adjustments in statistical models. A relation between average weekly alcohol consumption, blood pressure level, and hypertension prevalence has been consistent worldwide and continues to be studied in different populations to evaluate its contribution in relation to other risk factors. However, because of the above issues some caveats should be put on interpretation of data where authors emphatically imply causal relationships from statistical associations.The more recent cross-sectional studies have concentrated on the effects of pattern of drinking and the consumption of alcohol with or without food, beverage type, and the relative effects of alcohol on hypertension subtypes. Pattern of Drinking, Beverage Type, and Effects on Hypertension SubtypesThe relationship between the pattern of alcohol drinking and the risk of hypertension was addressed in a cross-sectional study of 2609 New Yorkers free from other cardiovascular disease 2 and considered further in an accompanying editorial 3 in which some of the key issues surrounding the topic were discussed. Compared with lifetime abstainers, those who reported drinking on a daily basis or apart from food had a significantly higher risk of hypertension, but this effect disappeared after accounting for the amount of alcohol consumed in the previous 30 days. When current drinkers only were studied and adjustment made for the amount of alcohol consumed in the previous 30 days, the risk of being hypertensive increased (64%) only in those who said they drank without food. Preference for any one type of beverage did not influence the association but the important potential confounder of dietary habits was not assessed. Nevertheless this finding was consistent with an earlier study of Italian...

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Association of Alcohol Consumption with Increase in Aortic Stiffness. A 9-Year Longitudinal Study in Middle-Aged Japanese Men.

Cited by 32 publications

References 11 publications

Excessive Alcohol Intake Increases the Risk of Arterial Stiffening in Men with Normal Blood Pressure

Excessive Alcohol Intake Increases the Risk of Arterial Stiffening in Men with Normal Blood Pressure

Alcohol consumption and arterial stiffness in men

Alcohol and Hypertension

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