Association of alcohol consumption with total serum immunoglobulin E levels and allergic sensitization in an adult population‐based survey

González‐Quintela, Arturo; Gudé, Francisco; Boquete, O.; Rey, José Manuel Gándara; Meijide, L. M.; Suarez, Felipe; Fernández-Merino, M C; Pérez, Luis‐Fernando; Vidal, Carmen

doi:10.1046/j.1365-2222.2003.01582.x

Cited by 90 publications

(127 citation statements)

References 38 publications

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“…In other studies, alcohol beverages consumption has been associated with increased risk for asthma and hay fever symptoms, allergic sensitization and serum IgE (45)(46)(47). The aMED score, used in the present study, considers total ethanol intake, irrespective of the different alcoholic beverages.…”

Section: Discussionmentioning

confidence: 98%

Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control

Barros

Moreira

Fonseca

et al. 2008

Allergy

121

104

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Background: The traditional Mediterranean diet is claimed to possess antioxidant and immune‐regulatory properties in several chronic diseases. Typical Mediterranean foods have recently been associated with improvement of symptoms of asthma and rhinitis in children. However the effect of adherence to Mediterranean diet on adult asthma outcomes is unknown. We aimed to investigate the association between adherence to Mediterranean diet and asthma control.Methods: Cross sectional study of 174 asthmatics, mean (SD) age of 40 (15) years. The patients were defined as controlled, in contrast to noncontrolled, if they showed FEV1 ≥ 80% of predicted, exhaled nitric oxide (NO) ≤35 ppb, and Asthma Control Questionnaire score <1. Dietary intake was obtained by a food frequency questionnaire, and Mediterranean diet was assessed by alternate Mediterranean Diet (aMED) Score. Logistic regression models adjusting for confounders were performed to estimate the association between Mediterranean diet and asthma control.Results: Controlled asthmatics (23%) had significantly higher aMED Score, intake of fresh fruit, and lower intake of ethanol compared to noncontrolled (77%). High adherence to Mediterranean diet reduced 78% the risk of noncontrolled asthma after adjusting for gender, age, education, inhaled corticosteroids and energy intake (OR = 0.22; 95% CI = 0.05–0.85; P‐trend = 0.028). The higher intake of fresh fruit decreased the probability of having noncontrolled asthma (OR = 0.29; 95% CI = 0.10–0.83; P‐trend = 0.015), while the higher intake of ethanol had the opposite effect (OR = 3.16; 95% CI = 1.10–9.11; P‐trend = 0.035).Conclusion: High adherence to traditional Mediterranean diet increased the likelihood of asthma to be under control in adults. The study introduces a novel link between diet and asthma control, as measured by symptoms, lung function and exhaled NO.

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Section: Discussionmentioning

confidence: 98%

Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control

Barros

Moreira

Fonseca

et al. 2008

Allergy

121

104

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“…A detailed description of the study has been reported elsewhere [35]. Briefly, it entails a cross-sectional survey of an age-stratified random sample of the adult population (≥18 years) from the municipality of A-Estrada (Spain).…”

Section: Methodsmentioning

confidence: 99%

“…The study profile is represented in figure 1. There were no differences in sex, age or habitat (rural/urban) between individuals who participated in the study and those who did not [35]. …”

Section: Methodsmentioning

confidence: 99%

“…Demographic data were assessed by means of an interviewer-administered questionnaire, as previously described [35, 36]. They included: (1) educational level in four categories: none, elementary (1–8 years), secondary (9–13 years), and university; (2) profession (farming/other); (3) smoking habit (yes/no); (4) alcohol consumption in three categories: none, 10–140 g/day, and more than 140 g/day; (5) habitat (rural/urban), and (6) pet (cat or dog) ownership (yes/no).…”

Section: Methodsmentioning

confidence: 99%

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<i>Toxocara</i> Infection Seroprevalence and Its Relationship with Atopic Features in a General Adult Population

Gonzalez-Quintela¹,

Gudé²,

Campos³

et al. 2006

Int Arch Allergy Immunol

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Background: The relationship of helminth infection with atopy is controversial. Toxocariasis is the most common helminth infection in industrialized countries. The study aimed to investigate the association between Toxocara exposure and atopic features. Methods: The study is based on a cross-sectional survey of 463 subjects, randomly selected (stratified by decades of age) from a general adult population. Toxocara exposure was defined by the presence of serum Toxocara antibodies. Main outcome measures included total serum IgE levels, skin prick tests (SPT) to a panel of 13 relevant aeroallergens, specific IgE to aeroallergens (Phadiatop test), and respiratory symptoms evaluated by means of a questionnaire. Results: A total of 134 subjects (weighted proportion 28.6%, 95% CI 26.5–30.7%) showed Toxocara exposure. Pet ownership, rural habitat, farming, and low educational level were associated with Toxocara exposure. Toxocara exposure was associated with both positive SPT (particularly to mites) and positive specific IgE (Phadiatop test) after adjusting for potential confounders. The effect of Toxocara exposure on total serum IgE levels and blood eosinophil count was different in SPT-positive subjects and SPT-negative individuals. In SPT-negative individuals, Toxocara exposure was associated with an increase in both serum IgE levels and eosinophil counts, whereas an opposite trend was observed in SPT-positive individuals. Toxocara exposure was not associated with respiratory symptoms. Conclusions: In this adult population, Toxocara exposure is associated with allergic sensitization, particularly to mites. There is evidence of an intriguing interaction between Toxocara exposure and allergic sensitization for both total serum IgE levels and blood eosinophil counts.

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“…Our evidence that EtOH polarizes the immune response toward Th2-driven immunity, deregulating the Th I response may explain the immunological impairments observed in alcohol abusers (1,3,(29)(30).…”

Section: Discussionmentioning

confidence: 76%

Chronic and Acute Alcohol Exposure Prevents Monocyte-Derived Dendritic Cells from Differentiating and Maturing

Buttari

Profumo

Mancinelli

et al. 2008

Int J Immunopathol Pharmacol

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Increasing evidence suggests that alcohol abuse may be linked to adverse immunomodulatory effects on immune responses. Our study was undertaken to clarify the immunological consequences of chronic and acute alcohol exposure on differentiation and maturation of human dendritic cells (DCs). Using immunochemical and cytoftuorimetric analysis we determined the phenotype and functions of monocyte-derived DCs from alcoholics and healthy subjects and analyzed their ability to respond to lipopolysaccharide (LPS) in the presence or absence of ethanol (EtOH) exposure. Our results showed that alcoholics' monocytes differentiated to immature DCs with altered phenotype and functions (aleiDCs). Alc-iDCs showed fewer Clrla" cells, weaker CD86 expression and higher HLA-DR expression associated with lower endocytosis and allostimulatory functions than iDCs from healthy subjects (control-iDCs). Despite these impairments, alc-iDCs produced TNF-a and IL-6 in large amounts. LPS stimulation failed to induce full phenotypical and functional alc-iDC maturation. In vitro acute EtOH exposure also prevented alc-iDCs and control-iDCs from maturing in response to LPS. T-cell priming experiments showed that EtOH treatment prevented LPS-stimulated control-iDCs from priming and polarizing naive allogeneic T cells into Thl cells, thus favouring a predominant Th2 environment. Collectively, our results provide evidence that chronic and acute alcohol exposure prevents DCs from differentiating and maturing in response to a microbial stimulus.Emerging evidence shows an increased incidence of infectious diseases, as well as a greater susceptibility to cancer in humans chronically abusing alcohol (1-5). Evidence from human and animal studies in vivo, as well as from in vitro experiments suggests that alcohol abuse may exert adverse immunomodulatory effects on innate and adaptive immune responses (4, 6-9). Alcoholinduced immune dysfunctions depend on various factors including the dose and duration of alcohol exposure (chronic vs acute) and on the presence and characteristics of additional stimuli such as microbial molecules.In chronic alcoholics and in a chronic ethanolfeeding model in mice, impaired antigen-specific T cell proliferation and a delayed-type hypersensitivity

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Association of alcohol consumption with total serum immunoglobulin E levels and allergic sensitization in an adult population‐based survey

Abstract: Alcohol consumption above a certain threshold is associated with an increase in total serum IgE levels. Alcohol consumption may also be associated with an increased prevalence of pollen sensitization.

Cited by 90 publications

References 38 publications

Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control

Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control

<i>Toxocara</i> Infection Seroprevalence and Its Relationship with Atopic Features in a General Adult Population

Chronic and Acute Alcohol Exposure Prevents Monocyte-Derived Dendritic Cells from Differentiating and Maturing

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