Association of Air Pollution Exposure With Psychotic Experiences During Adolescence

Newbury, Joanne B.; Arseneault, Louise; Beevers, Sean; Kitwiroon, Nutthida; Roberts, Stephen K.; Pariante, Carmine; Kelly, Frank J.; Fisher, Helen L.

doi:10.1001/jamapsychiatry.2019.0056

Cited by 155 publications

(138 citation statements)

References 69 publications

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“…For example, prenatal exposure to air pollution has been linked to increased risk for a range of psychiatric outcomes, including autism spectrum disorder in the first 5 years of life (Becerra et al, 2013;von Ehrenstein et al, 2014;Volk et al, 2011;Volk et al, 2013) and attention deficit hyperactivity disorder (ADHD) assessed through age 9 (Perera et al, 2012(Perera et al, , 2014Peterson et al, 2015). Exposure to air pollution, modeled at age 17, has also been linked to increases in psychotic experiences at age 18 (Newbury et al, 2019). Air pollution contains numerous potentially harmful compounds, including polycyclic aromatic hydrocarbons (PAH), which are common neurotoxicants released into the environment during incomplete combustion of fossil fuel, tobacco, and other organic material (Bostrom et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood

Pagliaccio

Herbstman

Perera

et al. 2020

Child Psychology Psychiatry

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Background: Risk for childhood psychopathology is complex and multifactorial, implicating direct and interacting effects of familial and environmental factors. The role of environmental neurotoxicants in psychiatric risk is of growing concern, including polycyclic aromatic hydrocarbons (PAH), common in air pollution. Prenatal PAH exposure is linked to adverse physical, behavioral, and cognitive outcomes as well as increasing psychiatric risk. It is unclear whether environmental exposures, like PAH, magnify the effects of exposure to early life stress (ELS), a critical risk factor for psychopathology. The current work aimed to test potential interactions between prenatal PAH exposure and psychosocial/socioeconomic stress on psychiatric symptoms in school-age children. Methods: Data were from the Columbia Center for Children's Environmental Health Mothers and Newborns longitudinal birth cohort study. Prenatal PAH exposure was ascertained though air monitoring during pregnancy and maternal PAH-DNA adducts at delivery. Mothers reported on ELS (child age 5) and on child psychiatric symptoms across childhood (child age 5, 7, 9, and 11) using the Child Behavior Checklist (CBCL). Results: Significant prenatal airborne PAH 9 ELS interactions (FDR-corrected) predicted CBCL Attention (b = 0.22, t(307) = 3.47, p < .001, p fdr = .003) and Thought Problems Tscores (b = 0.21, t(307) = 3.29, p = .001, p fdr = .004) at age 11 (n = 319). Relative to those with lower exposure, children with higher prenatal PAH exposure exhibited stronger positive associations between ELS and CBCL Attention and Thought Problem T-scores. This interaction was also significant examining convergent ADHD measures (Conners, DuPaul) and examining maternal PAH-DNA adducts (b = 0.29, t(261) = 2.48, p = .01; n = 273). A three-way interaction with assessment wave indicated that the PAH 9 ELS interaction on Attention Problems was stronger later in development (b = 0.03, t(1,601) = 2.19, p = .03; n = 477). Conclusions: Prenatal exposure to PAH, a common neurotoxicant in air pollution, may magnify or sustain the effects of early life psychosocial/socioeconomic stress on psychiatric outcomes later in child development. This work highlights the critical role of air pollution exposure on child mental health.

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Section: Introductionmentioning

confidence: 99%

Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood

Pagliaccio

Herbstman

Perera

et al. 2020

Child Psychology Psychiatry

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“…Accumulating evidence suggests that exposure to air pollution appears to adversely affect the brain [1], and air pollution has been associated with decreased cognitive function [2], dementia [3], and psychosis in adolescents [4]. Further, air pollution has been associated with smaller brain volumes, including smaller prefrontal volume in children [5] and older adults [6,7], smaller cortical whitematter volume in older women [8] and in children [1], and cortical gray matter [9].…”

Section: Introductionmentioning

confidence: 99%

Association between exposure to air pollution and thalamus volume in adults: A cross-sectional study

et al. 2020

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Background Air pollution has been associated with cognitive function and brain volume. While most previous research has examined the association between air pollution and brain volume in cortical structures or total brain volume, less research has investigated associations between exposure to air pollution and subcortical structures, including the thalamus. Further, the few available previous studies investigating associations between air pollution and thalamic volume have shown mixed results.

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“…Evidence from epidemiological and clinical studies supports the possibility that environmental toxicants such as mercury play a part in visual and auditory hallucinations. Exposure to environmental pollution, including heavy metals, has long been considered a possible risk factor for psychiatric disorders such as schizophrenia that are frequently accompanied by hallucinations [41][42][43]. Visual and auditory hallucinations often occur together, giving rise to the concept of 'bound' hallucinations [7].…”

Section: Plos Onementioning

confidence: 99%

Elemental imaging shows mercury in cells of the human lateral and medial geniculate nuclei

et al. 2020

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Interference with the transmission of sensory signals along visual and auditory pathways has been implicated in the pathogenesis of hallucinations. The relay centres for vision (the lateral geniculate nucleus) and hearing (the medial geniculate nucleus) appear to be susceptible to the uptake of circulating mercury. We therefore investigated the distribution of mercury in cells of both these geniculate nuclei. Materials and methods Paraffin-embedded tissue sections containing the lateral geniculate nucleus were obtained from 50 adults (age range 20-104 years) who at autopsy had a variety of clinicopathological conditions, including neurological and psychiatric disorders. The medial geniculate nucleus was present in seven sections. Sections were stained for mercury using autometallography. Laser ablation-inductively coupled plasma-mass spectrometry was used to confirm the presence of mercury. Results Ten people had mercury in cells of the lateral geniculate nucleus, and in the medial geniculate nucleus of three of these. Medical diagnoses in these individuals were: none (3), Parkinson disease (3), and one each of depression, bipolar disorder, multiple sclerosis, and mercury self-injection. Mercury was distributed in different groups of geniculate capillary endothelial cells, neurons, oligodendrocytes, and astrocytes. Mass spectrometry confirmed the presence of mercury. Conclusion Mercury is present in different combinations of cell types in the lateral and medial geniculate nuclei in a proportion of people from varied backgrounds. This raises the possibility that mercury-induced impairment of the function of the geniculate nuclei could play a part in the

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Association of Air Pollution Exposure With Psychotic Experiences During Adolescence

Cited by 155 publications

References 69 publications

Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood

Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood

Association between exposure to air pollution and thalamus volume in adults: A cross-sectional study

Elemental imaging shows mercury in cells of the human lateral and medial geniculate nuclei

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