Association of age with risk of major depression among patients with chronic kidney disease over midlife: a nationwide cohort study in Taiwan

Chen, Shih-Feng; Chien, Yu-Huei; Chen, Pau‐Chung; Wang, I-Jen

doi:10.1017/s1041610218001576

Cited by 9 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the emotional suffering associated with a decrease in the standard of life among the elderly population is depression (Chen et al., 2019). It is associated with a decrease in the concentration of serotonin as it binds to specific 5‐HT receptors present outside of the cell.…”

Section: Biological Activity and Structure–activity Relationship Of P...mentioning

confidence: 99%

The medicinal chemistry of piperazines: A review

Faizan,

Kumar,

Mazumder

et al. 2024

Chem Biol Drug Des

View full text Add to dashboard Cite

The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases. Piperazine derivatives are unique and can easily be modified for the desired pharmacological activity. The two opposing nitrogen atoms in a six‐membered piperazine ring offer a large polar surface area, relative structural rigidity, and more acceptors and donors of hydrogen bonds. These properties frequently result in greater water solubility, oral bioavailability, and ADME characteristics, as well as improved target affinity and specificity. Various synthetic protocols have been reported for piperazine and its derivatives. In this review, we focused on recently published synthetic protocols for the synthesis of the piperazine and its derivatives. The structure–activity relationship concerning different biological activities of various piperazine‐containing drugs has also been highlighted to provide a good understanding to researchers for future research on piperazines.

show abstract

Section: Biological Activity and Structure–activity Relationship Of P...mentioning

confidence: 99%

The medicinal chemistry of piperazines: A review

Faizan,

Kumar,

Mazumder

et al. 2024

Chem Biol Drug Des

View full text Add to dashboard Cite

show abstract

“…Depression is the most common cause of emotional suffering related to a decrease in quality of life in the older population [1,2] . But, recently the prevalence of depression in young adults and adolescents has increased sharply [3] .…”

Section: Introductionmentioning

confidence: 99%

Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure‐Activity Relationships

et al. 2021

View full text Add to dashboard Cite

Depression is the single largest contributor to global disability with a huge economic and social burden on the world. There are a number of antidepressant drugs on the market, but treatment‐resistant depression and relapse of depression in a large number of patients have increased problems for clinicians. One peculiarity observed in most of the marketed antidepressants is the presence of a piperazine substructure. Although piperazine is also used in the optimization of other pharmacological agents, it is almost extensively used for the development of novel antidepressants. One common understanding is that this is due to its favorable CNS pharmacokinetic profile; however, in the case of antidepressants, piperazine plays a much bigger role and is involved in specific binding conformations of these agents. Therefore, in this review, a critical analysis of the significance of the piperazine moiety in the development of antidepressants has been performed. An overview of current developments in the designing and synthesis of piperazine‐based antidepressants (2015 onwards) along with SAR studies is also provided. The various piperazine‐based therapeutic agents in early‐ or late‐phase human testing for depression are also discussed. The preclinical compounds discussed in this review will help researchers understand how piperazine actually influences the design and development of novel antidepressant compounds. The SAR studies discussed will provide crucial clues about the structural features and optimizations required to enhance the efficacy and potency of piperazine‐based antidepressants.

show abstract