Association of Age With Risk of Hospitalization for Respiratory Syncytial Virus in Preterm Infants With Chronic Lung Disease

Winterstein, Almut G.; Choi, Yoonyoung; Meissner, H. Cody

doi:10.1001/jamapediatrics.2017.3792

Cited by 15 publications

(7 citation statements)

References 24 publications

(47 reference statements)

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“…All children living in the province of Ontario and who were between 0 and 36 months of age between Sept 1, 2011 -Aug 31, 2012 were eligible for cohort inclusion. We chose to include only young children as this would capture the majority of RSV hospitalizations [16]. Children who were hospitalized for RSV were matched 1:4 to children who were not hospitalized for RSV over the study period based on age (same year of birth ±1 month) and sex.…”

Section: Patients and Settingmentioning

confidence: 99%

The association between climate, geography and respiratory syncitial virus hospitalizations among children in Ontario, Canada: a population-based study

et al. 2020

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Background: Respiratory syncytial virus (RSV) infection is a major cause of hospitalization in young children in Canada, despite routine immunoprophylaxis in those with medical risk factors. We aimed to determine if cold temperatures are associated with RSV hospitalization. Methods: We conducted a population-based nested case-control study of children in Ontario, Canada, using health administrative data. We compared children hospitalized for RSV between September 1, 2011 and August 31, 2012 to age and sex matched controls. We used multivariable logistic regression to identify associations between minimum daily temperature and RSV hospitalizations with adjustment for sociodemographic and environmental factors. Results: We identified 1670 children with RSV hospitalizations during the study period and 6680 matched controls. Warmer temperatures (OR = 0.94, 95%CI: 0.93, 0.95) were associated with lower odds of RSV hospitalization. Southern ecozone (OR = 1.6, 95%CI: 1.2, 2.1), increased ozone concentration (OR = 1.03, 95%CI: 1.01, 1.06) and living in a lower income neighbourhood (OR = 1.3, 95%CI: 1.1, 1.5) significantly increased the odds of RSV hospitalization, as did living in a household with a larger number of siblings in a sub-cohort of children (OR = 1.34, 95%CI: 1.26, 1.41). Conclusions: In Ontario, the likelihood of having an RSV hospitalization is associated with colder temperature exposures and socioeconomic factors.

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Section: Patients and Settingmentioning

confidence: 99%

The association between climate, geography and respiratory syncitial virus hospitalizations among children in Ontario, Canada: a population-based study

et al. 2020

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“…Adjustment variables were sex, severe bronchopulmonary dysplasia, breastfeeding at discharge, mother's educational level, presence of siblings at home and childcare at one year of age. These factors are among the most important risk factors for RSV infections 15,16 and were also associated with full RSV prophylaxis in the EPIPAGE‐2 cohort 11 …”

Section: Methodsmentioning

confidence: 99%

Full compliance with Respiratory syncytial virus prophylaxis was associated with fewer respiratory‐related hospital admissions in preterm children: A cohort study

Torchin

Charkaluk

Rousseau³

et al. 2020

Acta Paediatrica

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Aim Although well documented in randomised trials, the efficacy of prophylaxis against respiratory syncytial virus (RSV) in real‐word conditions is less studied. The objective was to assess the impact of partial versus full RSV prophylaxis for acute respiratory infections (ARIs) and ARI‐related hospital admissions in preterm children. Methods This study included children born preterm in 2011 in France who were eligible for RSV prophylaxis and received at least one palivizumab dose from October 2011 to March 2012. Full prophylaxis was defined as receiving at least one palivizumab dose for each month of RSV exposure in the community. Children with full and partial prophylaxis were matched, and odds of ARIs and ARI‐related hospital admission were compared by logistic regression. Results Full prophylaxis concerned 861/1083 (80%) children. As compared with full prophylaxis, partial prophylaxis was not associated with ARI occurrence (odds ratio OR 1.3, 95% confidence interval CI 0.9‐1.9) but was significantly associated with ARI‐related hospital admission during the RSV epidemic (OR 1.9, 95% CI 1.2‐2.9). Conclusion During the 2011‐2012 RSV epidemic, hospital admission rates were higher for preterm children with partial than full RSV prophylaxis. Improving compliance could help alleviate the burden of RSV on healthcare systems.

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“…We chose to include only young children as this would capture the majority of RSV hospitalizations. 16 Children who were hospitalized for RSV were matched 1:4 to children who were not hospitalized for RSV over the study period based on age (same year of birth ±1 month) and sex. RSV exposure status, and whether they were RSV positive or negative was not examined for the non-hospitalized children.…”

Section: Patients and Settingmentioning

confidence: 99%

The association between climate, geography and respiratory syncitial virus hospitalizations among children in Ontario, Canada: a population-based study

Radhakrishnan

Ouedraogo

Shariff

et al. 2020

Preprint

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Background: Respiratory syncytial virus (RSV) infection is a major cause of hospitalization in young children in Canada, despite routine immunoprophylaxis in those with medical risk factors. We aimed to determine if cold temperatures are associated with RSV hospitalization. Methods: We conducted a population-based nested case–control study of children in Ontario, Canada, using health administrative data. We compared children hospitalized for RSV between September 1, 2011 and August 31, 2012 to age and sex matched controls. We used multivariable logistic regression to identify associations between minimum daily temperature and RSV hospitalizations with adjustment for sociodemographic and environmental factors. Results: We identified 1670 children with RSV hospitalizations during the study period and 6680 matched controls. Warmer temperatures (OR=0.94, 95%CI: 0.93, 0.95) were associated with lower odds of RSV hospitalization. Southern ecozone (OR=1.6, 95%CI: 1.2, 2.1), increased ozone concentration (OR=1.03, 95%CI: 1.01, 1.06) and living in a lower income neighbourhood (OR=1.3, 95%CI: 1.1, 1.5) significantly increased the odds of RSV hospitalization, as did living in a household with a larger number of siblings in a sub-cohort of children (OR=1.34, 95%CI: 1.26, 1.41). Conclusions: In Ontario, the likelihood of having an RSV hospitalization is associated with colder temperature exposures and socioeconomic factors.

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Association of Age With Risk of Hospitalization for Respiratory Syncytial Virus in Preterm Infants With Chronic Lung Disease

Cited by 15 publications

References 24 publications

The association between climate, geography and respiratory syncitial virus hospitalizations among children in Ontario, Canada: a population-based study

The association between climate, geography and respiratory syncitial virus hospitalizations among children in Ontario, Canada: a population-based study

Full compliance with Respiratory syncytial virus prophylaxis was associated with fewer respiratory‐related hospital admissions in preterm children: A cohort study

The association between climate, geography and respiratory syncitial virus hospitalizations among children in Ontario, Canada: a population-based study

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