Association of Age with Mortality Rate after Femoropopliteal Endovascular Therapy for Intermittent Claudication

Abstract

This study aimed to reveal the mortality risk by age in patients undergoing femoropopliteal endovascular therapy for intermittent claudication, in comparison to the national age-specific standard value. Methods:We analyzed 2056 patients undergoing endovascular therapy for moderate to severe intermittent claudication between 2010 and 2018, performed at five cardiovascular centers in Japan. The 3-year mortality risk by age was compared with the data from year-and sex-matched Japanese citizens, which were obtained from Japan's national life table data. Clinical characteristics associated with age in the study patients were also explored. Results:The mean age was 73 9 years. The 3-year mortality risk was increased with age in the patient population, from 6.4% for patients aged 65 years to 21.2% for those aged ≥ 85 years. On the contrary, its risk ratio relative to the matched citizens of the same age was decreased with age; the relative risk ratio was 3.08 for patients aged 65 years (P 0.001) and 0.60 for those aged ≥ 85 years (P 0.016). Current smoking, body mass index ≥ 25 kg/m 2 , hyperlipidemia, diabetes mellitus, and dialysis dependence were inversely associated with age (all P 0.05). Conclusion:Mortality risk increased with age, but the risk ratio relative to the matched citizens decreased with age. Younger patients had a higher mortality risk relative to the matched citizens, whereas patients aged ≥ 85 years had a lower mortality risk relative to the matched citizens. Younger patients were more likely to accumulate cardiovascular risk factors. endovascular therapy in older patients.Age is a well-known risk factor for mortality in various populations, and there is no exception in a population with peripheral artery disease 5) . Furthermore, many previous studies have reported that the mortality risk of patients with intermittent claudication is two to three times higher than that of the general population with adjustment for age 6,7) . In this context, older patients with intermittentCopyright©2021 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

Association of Smoking, Diabetes, and Dialysis with the Presence of Popliteal Lesions in Femoropopliteal Artery Disease

“…First, our data were cross-sectional, and we could not prove causal relationships between cardiovascular risk factors and affected arterial segments. Respective cardiovascular risk factors per se might be complexly linked with one another 26) . Second, details of cardiovascular risk factors [27][28][29][30] , medications [31][32][33][34] , and other general conditions 35,36) were not analyzed in this study.…”