Association of age at menarche with adult leg length and trunk height: Speculations in relation to breast cancer risk

Osuch, Janet; Karmaus, Wilfried; Hoekman, Peter; Mudd, Lanay M.; Zhang, Jie; Haan, Pam; Mikucki, Dorota

doi:10.3109/03014460903213845

Cited by 14 publications

(13 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the association of E 2 with tibial length became negative after menarche. This finding explains in part the observation that earlier age at menarche is associated with shorter stature in adulthood45, 46 because an earlier age at menarche, as shown in this study, corresponds to an earlier plateau of E 2 concentration at a high level, which decelerates bone lengthening. Our results echo the findings in animal studies that the effect of estrogen on longitudinal bone growth is biphasic: At low levels, estrogen stimulates growth,13, 47 whereas higher levels of estrogen have potent inhibitory effects on longitudinal growth by accelerating epiphyseal closure 48…”

Section: Discussionsupporting

confidence: 71%

Concerted actions of insulin-like growth factor 1, testosterone, and estradiol on peripubertal bone growth: A 7-year longitudinal study

Wang

et al. 2011

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

A better understanding of how bone growth is regulated during peripuberty is important for optimizing the attainment of peak bone mass and for the prevention of osteoporosis in later life. In this report we used hierarchical models to evaluate the associations of insulin-like growth factor 1 (IGF-1), estradiol (E 2 ), and testosterone (T) with peripubertal bone growth in a 7-year longitudinal study. Two-hundred and fifty-eight healthy girls were assessed at baseline (mean age 11.2 years) and at 1, 2, 3.5, and 7 years. Serum concentrations of IGF-1, E 2 , and T were determined. Musculoskeletal properties in the left lower leg were measured using peripheral quantitative computed tomography (pQCT). Serum levels of IGF-1, E 2 , and T increased dramatically before menarche, whereas they decreased, plateaued, or increased at a lower rate, respectively, after menarche. IGF-1 level was positively associated with periosteal circumference (PC) and total bone mineral content (tBMC) throughout peripuberty but not after adjustment for muscle cross-sectional area (mCSA). On the other hand, IGF-1 was associated with tibial length (TL) independently of mCSA before menarche. T was positively associated with TL, PC, tBMC, and cortical volumetric bone mineral density, independent of mCSA, before menarche but not after. E 2 was associated with TL positively before menarche but negatively after menarche. These findings suggest that during puberty, circulating IGF-1 promotes bone periosteal apposition and mass accrual indirectly, probably through stimulating muscle growth, whereas the effects of sex steroids on bone growth differ before and after menarche, presenting a biphasic pattern. Hence the concerted actions of these hormones are essential for optimal bone development in peripuberty. ß

show abstract

Section: Discussionsupporting

confidence: 71%

Concerted actions of insulin-like growth factor 1, testosterone, and estradiol on peripubertal bone growth: A 7-year longitudinal study

Wang

et al. 2011

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…Although girls typically become taller and reach puberty earlier than boys (boys catch up in later adolescence), the possibility of advancing pubescence by way of a high FS environment is a serious concern. Earlier onset of pubertal milestones has been linked to risk of breast cancer, apart from other types of diseases (27,28) ; however, some studies have challenged this association (29,30) . Although obesity does not appear to induce precocious puberty in boys (31) , it often precedes chronic diseases in adulthood.…”

Section: Fast-food Outlets Body Composition and Gendermentioning

confidence: 99%

Fast-food outlets and walkability in school neighbourhoods predict fatness in boys and height in girls: a Taiwanese population study

Chiang

Wahlqvist

Lee

et al. 2011

Public Health Nutr.

View full text Add to dashboard Cite

Objective: There is increasing evidence that the school food environment contributes to childhood obesity and health in various locations. We investigated the influence of fast-food stores and convenience food stores (FS and CS, respectively) on growth and body composition in a range of residential densities for North-east Asian food culture. Design: Anthropometrics and birth weight of schoolchildren were obtained. Geocoded mapping of schools and food outlets was conducted. Multivariable linear regression models, adjusted for father's ethnicity and education, as well as for household income, pocket money, birth weight, physical activity, television watching, food quality and region, were used to predict body composition from school food environments. Results: Remote and socially disadvantaged locations had the highest prevalence of lower weight, BMI, waist circumference and triceps skinfold thickness. Food store densities, FS and CS, were highest in urban Taiwan and lowest in remote Taiwan. In the fully adjusted models, FS densities predicted weight and BMI in boys; there was a similar association for waist circumference, except when adjusted for region. FS densities also predicted height for girls. Except for weight and BMI in boys, CS did not have effects evident with FS for either boys or girls. Conclusions: A high FS density, more than CS density, in Taiwan increased the risk of general (BMI) and abdominal (waist circumference) obesity in boys and stature in girls. These findings have long-term implications for chronic disease in adulthood.

show abstract

“…For example, a recent paper questions whether the usual relation between adult height and age at menarche holds for women born more recently. [27] This is an important question since both early menarche, and paradoxically, tall stature, are associated with increased risk of breast cancer, even though women with early menarche “tend” possibly? up to now, to be shorter rather than taller.…”

Section: Early Life Origins Of Breast Cancermentioning

confidence: 99%

Developmental and environmental origins of breast cancer: DDT as a case study

Cohn

2011

Reproductive Toxicology

View full text Add to dashboard Cite

More than 20 studies of serum “DDT” and breast cancer have found little support for the hypothesis that exposure influences risk of breast cancer. However, studies share common limitations including the inability to account for exposure in early life when the breast may be most vulnerable and the inability to measure exposure to the primary components of commercial DDT. This paper 1) Summarizes evidence regarding critical windows of exposure for breast cancer 2) Summarizes lessons learned from initial efforts to study DDT and breast cancer 3) Reviews evidence from the Child Health and Development Studies (CHDS) where exposure was measured in young women using blood samples obtained during active exposure, 1- 3 days after delivery. 4) Suggests approaches for human studies that might advance understanding of environmental stressors in the developmental origins of disease.

show abstract

Association of age at menarche with adult leg length and trunk height: Speculations in relation to breast cancer risk

Cited by 14 publications

References 38 publications

Concerted actions of insulin-like growth factor 1, testosterone, and estradiol on peripubertal bone growth: A 7-year longitudinal study

Concerted actions of insulin-like growth factor 1, testosterone, and estradiol on peripubertal bone growth: A 7-year longitudinal study

Fast-food outlets and walkability in school neighbourhoods predict fatness in boys and height in girls: a Taiwanese population study

Developmental and environmental origins of breast cancer: DDT as a case study

Contact Info

Product

Resources

About