Association of age at diagnosis and Crohn's disease phenotype

Abstract

patients diagnosed with CD ≥ 60 were more likely to have colonic disease and non-complicated disease. However, the association between age at diagnosis and complicated disease did not persist after adjustment for confounding variables.

Patients with perianal Crohn's disease have poor disease outcomes after primary bowel resection

“…In this study, patients with perianal disease were younger in age and diagnosed earlier in their lifetime. These results are consistent with previous studies that perianal disease was less common in late‐onset CD . Age of onset was considered as significant prognostic factor, that late‐onset CD was associated with better clinical outcome .…”

“…These results are consistent with previous studies that perianal disease was less common in late-onset CD. [16][17][18] Age of onset was considered as significant prognostic factor, that late-onset CD was associated with better clinical outcome. 19 In our study, we could observe the trend of decreased risk of reoperation as age of diagnosis went up, but it was not statistically significant.…”

Systematic review with meta‐analysis: inflammatory bowel disease in the elderly

“…Genetic factors seem to play a more prevalent role in paediatric patients with IBD than in older individuals . In this respect, older patients are less likely to have a family history of IBD, perhaps reflecting greater environmental influence than in younger patients …”

Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?

“…En nuestro estudio, el compromiso perianal fue similar al analizar los pacientes por edad actual, y tiende a ser similar también cuando evaluamos compromiso perianal en pacientes diagnosticados sobre los 60 años 21 . Otros estudios han demostrado que pacientes con diagnóstico tardío tienen menos compromiso perianal, el cual Enfermedad inflamatoria intestinal en el adulto mayor -D. Simian et al es conocido por ser un factor de mal pronóstico en pacientes con EII 3,9,11,22 . La diferencia puede ser explicada por el menor número de pacientes > 60 años incluidos en nuestro estudio.…”