Association of adverse drug reaction to anti-tuberculosis medication with quality of life in patients in a tertiary referral hospital

Abstract

Introduction: Adverse drug reactions can develop when using anti-tuberculosis medication, and the effects of the drugs can also significantly hinder the treatment of patients. Methods: A cross-sectional survey was conducted in 73 patients using two standardized questionnaires and the World Health Organization Quality of Life-Bref. Results: All patients reported the presence of adverse drug reactions, 71.6% of which are minor and 28.3% both major and minor. The global quality of life analysis showed that patients with tuberculosis have a good average (67.3%). Conclusions: There is an association between quality of life and adverse drug reaction, educational level, and vulnerability.

Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy

“…Some research had proven that tuberculosis and its consequences affected HR-QoL not only due to somatic symptom but also had psychological and social impacts. 20–22 Moreover, in DR-TB, long-term therapy and toxic drugs render the implementation of curing processes more difficult. 23 A systematic review has reported that the HR-QoL of MDR-TB patients was considerably lower than DS-TB patients, especially in the first six months of therapy.…”

“…Two of the studies indicated associations between ADR and HR-QoL. 20 , 22 A study reported by Sineke used the SF-36 questionnaire to investigate the mental component summary (MCS) and the physical component summary (PCS). DR-TB patients with reported ADR more likely had lower MCS (aRR 2.24 95% confidence interval (CI) 1.53–3.27) and PCS (aRR 1.52 95% CI 1.07–2.18) scores than patients who did not report ADR.…”

“… Both DR-TB and DS-TB patients, >18 years old (n= 73) Abbreviated World Health Organization Quality of Life Questionnaire (WHOQOL-Bref) There were significant association between the type of ADR and HRQoL in univariate analysis (p value =0.016) and in multivariate analysis (p value =0.012). Valadares et al, 2020 20 Abbreviations : HRQoL, health-related quality of life; ADR, adverse drug reaction; MCS, mental component summary; PCS, physical component summary; aRR, adjusted relative risk; CI, confidence interval; DR-TB, drug resistant tuberculosis; MDR-TB, multi-drug resistant tuberculosis. …”

Surgical Management of Bacille Calmette-Guérin Vaccine-related Regional Lymphadenitis in Infants

“…Needle aspiration with or without instillation of isoniazid or rifampicin can decrease the occurrence of spontaneous rupture but does not debride the lesions [5,21,26,27] . Surgical management of BCG vaccinerelated lymphadenitis has been reported to have fewer side effects and shorter treatment time [10,13,17,28] .…”

Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review

“…The adverse effects can affect the quality of care, but also the physical, organic integrity of patients and psycho-affective and social, directly interfering with the quality of life [4]. They can lead to major morbidity, including blindness, deafness, myelosuppression, renal failure or liver failure, resulting in hospitalization or even death, as well as treatment interruption or failure [3,5,6].…”