Association of adiposity with diabetes: A national research among Chinese adults

Abstract

Background Adiposity is an established risk factor for diabetes. The different measurements of adiposity for predicting diabetes have been compared in recent studies in Western countries. However, similar researches among Chinese adults are limited. Methods Data were collected from a national survey conducted during September 2014 and May 2015 Among Chinese adults aged 40 years and older across 30 China's provinces. Multilevel model analysis was performed to examine the impacts of different obesity indices [body mass index (BMI), waist circumference (WC), lipid accumulation product index (LAP), visceral adiposity index (VAI), and body adiposity index (BAI)] on the risk of diabetes. Results A total of 162 880 participants were included in this study. Of them, 54.47% were female. With an increase in BMI, WC, LAP, VAI, and BAI, the prevalence of diabetes significantly grew (P < 0.001). The multilevel model analysis showed that WC has the strongest impact on diabetes prevalence, while BAI was the weakest. For one SD increment in BMI, WC, LAP, VAI, and BAI, the prevalence of diabetes increased by 27.0% (Odds Ratio (OR) = 1.270, 95% Confidence interval (CI) = 1.251–1.289), 37.4% (OR = 1.374, 95% CI = 1.346–1.401), 28.1% (OR = 1.281, 95% CI = 1.266–1.297), 22.0% (OR = 1.220, 95% CI = 1.204–1.236), and 17.4% (OR = 1.174, 95% CI = 1.151–1.192), respectively. Conclusion Obesity indicators of BMI, WC, LAP, VAI, and BAI have significant positive relationships with the risk of diabetes. WC has the strongest impact on diabetes, while BAI has the weakest.

Relationship between obesity indexes and triglyceride glucose index with gastrointestinal cancer among the US population

“…LAP was first proposed as an index in 2009 to predict the cardiovascular risk of polycystic ovary syndrome ( Wiltgen et al, 2009 ). Later research found that LAP also has a good predictive value for diabetes and hypertension ( Fu et al, 2021 , Wang et al, 2021 ). Shi analyzed 13,055 hypertensive patients and found that with the increase of LAP level, the risk of chronic kidney disease increased ( Shi et al, 2022 ).…”

The predictive significance of lipid accumulation products for future diabetes in a non-diabetic population from a gender perspective: an analysis using time-dependent receiver operating characteristics

“…showed that LAP was positively correlated with the incidence of diabetes in females, while there was no significant association in the male population. Nevertheless, most studies ( 28 – 34 , 54 – 57 ) still supported a stronger association of LAP with diabetes in females than in males, which is consistent with the conclusions proposed in a recent meta-analysis ( 36 ) conducted by Khanmohammadi S et al. Our results in a cohort with up to 13 years of follow-up supported this conclusion, and in addition, we did not find effect modifiers that significantly affected the relationship between LAP and diabetes in either gender in the subgroup analysis, and the findings provided new evidence for the previous conclusion.…”

Metabolic (Dysfunction)-Associated Fatty Liver Disease in Chinese Patients with Type 2 Diabetes from a Subcenter of the National Metabolic Management Center

“…Prevalence and Awareness of MAFLD. Mainland China has seen a rapid increase in the burden of metabolic diseases owing to rapid economic transition and unhealthy lifestyles [19]. The latest prevalence of diabetes diagnosed by the American Diabetes Association criteria was 12.8% [11], and the rate of overweight/obesity exceeded 50% [10] among Chinese adults.…”