Association of adiponectin gene variants with idiopathic recurrent miscarriage according to obesity status: a case–control study

Abstract

BackgroundThis study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced by obesity.MethodsRetrospective case–control study performed in outpatient obstetrics/gynecology clinics. Study subjects comprised 308 women with RPL, defined as ≥ 3 consecutive miscarriages of unknown etiology, and 310 control women. ADIPOQ genotyping was done by allele exclusion method on real-time PCR.ResultsOf the 14 ADIPOQ variants tested, the minor allele frequency (MAF) of rs4632532, rs17300539, rs266729, rs182052, rs16861209, and rs7649121 were significantly higher, while rs2241767, and rs1063539 MAF were lower in RPL cases, hence assigning RPL-susceptibility and protection to these variants, respectively. Higher frequencies of heterozygous rs17300539 and rs16861209, and homozygous rs4632532, rs266729, and rs182052 genotypes, and reduced frequencies of heterozygous rs1063539 and rs2241767, homozygous rs2241766 genotypes were seen in RPL cases. ADIPOQ rs4632532, and rs2241766 were associated with RPL in obese, while rs1063539 and rs16861209 were associated with RPL in non-obese women; rs182052 and rs7649121 associated with RPL independently of BMI changes. Based on LD pattern, two haplotype blocks were identified. Within Block 1 containing rs4632532, rs16861194, rs17300539, rs266729, rs182052, rs16861209, rs822396, and rs7649121, increased frequency of CAGGACAT and TAACGAAA, and reduced frequency of TAGCGCAA haplotypes were seen in RPL cases when compared to controls, thereby assigning RPL susceptibility and protection, respectively.ConclusionThis is the first study to document contribution of ADIPOQ variants and haplotypes with RPL, and also to underscore the contribution of obesity to genetic association studies.

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

“…Therefore, preeclamptic -11377GG genotype carriers are likely to express low levels of adiponectin, resulting in impaired control of glycemia. Also, −11377G allele carriers have been associated with chronic hypertension (Ong et al, 2010), recurrent pregnancy loss (Dendana et al, 2018), and gestational diabetes (Pawlik et al, 2017) in non-Latin American populations.…”

Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia

“…Adiponectin (AdipoQ) is a 30 KDa adipokine encoded by the AdipoQ gene, mostly produced by adipocytes and is rich in human plasma ( Dendana et al, 2018 ). AdipoQ is recognized to enhance the insulin susceptibility of target organs including muscles and liver, finally controlling fatty acid metabolism and peripheral glucose levels ( Hotta et al, 2001 ; Yamauchi et al, 2001 , 2002 ).…”

Functional Haplotypes in the ADIPOQ Gene are Associated with Underweight, Immunosuppression and Viral Suppression in Kenyan HIV-1 Infected Antiretroviral Treatment Naive and Experienced Injection Substance Users

“…In contrast, TG carriers were more in HIV-1 ART-naive ISUs compared with -experienced suggesting that ADIPOQ haplotypes could be influencing disease outcomes in HIV-1 ISUs. Previous studies have reported ADIPOQ haplotypes modulating obesity and type 2 diabetes ( 31 ). There is limited data on ADIPOQ haplotype modulation of disease outcomes in infectious diseases including HIV-1.…”

“…Rate of GC carriage was lower in the -naive compared to -experienced ISUs. In contrast, TG carriers were more in HIV-1 ART-naive ISUs compared with -experienced suggesting that ADIPOQ haplotypes could be influencing disease (31). There is limited data on ADIPOQ haplotype modulation of disease outcomes in infectious diseases including HIV-1.…”