Association of adipokines and joint biomarkers with cartilage-modifying effects of weight loss in obese subjects

King, Lauren; Henneicke, Holger; Seibel, Markus J.; March, Lyn; Anandacoomarasmy, A.

doi:10.1016/j.joca.2014.11.020

Cited by 27 publications

(22 citation statements)

References 47 publications

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“…Metabolites characteristics including energy metabolism and lipid and carbohydrate metabolism in the OA patients' synovial tissue cultures were significantly decreased compared with those with little or no evidence of the disease [23, 24]. Obesity increased mass and joint load and altered proinflammatory factor adipokines secretion, leading to the chronic low grade inflammatory status in joint tissues [25, 26]. Additionally, cholesterol accumulation in the cartilage can impair the efflux function of cartilage, hence inducing OA [27, 28].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta‐Analysis

Wang

Cheng

Shao

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Background. Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis. Methods. Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies. Data were extracted separately by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results. The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search. The crude pooled OR is 2.24 (95% CI = 1.38–3.64). Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study. The pooled adjusted OR remained significant with pooled adjusted OR 1.05 (95% CI = 1.03–1.07, p < 0.00001). No publication bias was found in the present meta-analysis. Conclusions. The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta‐Analysis

Wang

Cheng

Shao

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…In addition, Ku et al and Karvonen-Gutierrez et al reported that SF and serum leptin levels are directly correlated with the radiographic severity of OA [141, 142] and also with proinflammatory cytokines, MMP-1, and MMP-3 levels in OA patients, suggesting the possible use of leptin as a potential biomarker for quantitative detection of OA severity. In a recent study, SF leptin concentrations were associated also with knee and hip pain in OA patients [140, 143, 144]. In addition, in Chinese population, serum levels of leptin were independently associated with increased knee cartilage volume assessed by radiography [145].…”

Section: Adipokines In the Pathobiology Of Osteoarthritic Cartilagementioning

confidence: 99%

“…A lower leptin : adiponectin ratio correlated with lower knee OA pain [143]. Furthermore, it has determined that weight loss is associated with an increase in adiponectin and a decrease in leptin and cartilage oligomeric matrix protein plasma levels in obese subjects [144]. This suggests that lower levels of adiponectin are related to a more aggressive disease and that higher levels have anti-inflammatory properties.…”

Section: Adipokines In the Pathobiology Of Osteoarthritic Cartilagementioning

confidence: 99%

Adipokine Contribution to the Pathogenesis of Osteoarthritis

Azamar-Llamas

Hernández-Molina

Ramos-Ávalos

et al. 2017

Mediators of Inflammation

132

106

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Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis. Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines. In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis. Furthermore, drugs such as rosuvastatin or rosiglitazone have demonstrated chondroprotective and anti-inflammatory effects in cartilage explants from patients with OA. Thus, it seems that adipokines are important factors linking obesity, adiposity, and inflammation in OA. In this review, we are focused on establishing the physiological mechanisms of adipokines on cartilage homeostasis and evaluating their role in the pathophysiology of OA based on evidence derived from experimental research as well as from clinical-epidemiological studies.

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“…While a number of biomarker studies have focused on the release of cartilage matrix proteins such as collagens, proteoglycans, or cartilage oligomeric matrix protein in the serum and synovial fluid567, mounting evidence suggests that OA is more than just cartilage wear and tear, as both systemic and local intra-articular metabolic factors such as inflammation appear to play a pivotal role in joint degeneration89. Thus, in addition to matrix degradation products, inflammatory cytokines and adipokines may also have potential as OA biomarkers that are related to disease mechanisms1011.…”

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confidence: 99%

Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair

Kimmerling

Little

et al. 2017

Sci Rep

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High-fat diet-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing. The objective of this study was to determine the associations among serum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and wound healing in a pre-clinical obese mouse model of OA. Male C57BL/6 J mice were fed either a low-fat (10% kcal) or one of three high-fat (HF, 60% kcal) diets rich in saturated fatty acids (SFAs), ω-6 or ω-3 polyunsaturated FAs (PUFAs). OA was induced by destabilization of the medial meniscus. Mice also received an ear punch for evaluating wound healing. Serum and synovial fluid were collected for lipidomic and adipokine analyses. We demonstrated that the serum levels of ω-3 PUFAs were negatively correlated with OA and wound size, but positively correlated with adiponectin levels. In contrast, most ω-6 PUFAs exhibited positive correlations with OA, impaired healing, and inflammatory adipokines. Interestingly, levels of pentadecylic acid (C15:0, an odd-chain SFA) and palmitoleic acid were inversely correlated with joint degradation. This study extends our understanding of the links of FAs with OA, synovitis and wound healing, and reports newly identified serum and synovial fluid FAs as predictive biomarkers of OA in obesity.

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Association of adipokines and joint biomarkers with cartilage-modifying effects of weight loss in obese subjects

Abstract: Adiponectin and leptin may be associated with cartilage loss. Further work will determine the relative contributions of metabolic and mechanical factors in the obesity-related joint changes.

Cited by 27 publications

References 47 publications

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta‐Analysis

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta‐Analysis

Adipokine Contribution to the Pathogenesis of Osteoarthritis

Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair

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