Association of Adenosine Deaminase, Superoxide Dismutase, and Catalase Activities with Helicobacter pylori

Abstract

Our purpose was to investigate associations between adenosine deaminase (ADA), superoxide dismutase (SOD), and catalase (CAT) activities and H. pylori.Ninety-nine patients were studied. Eight antral mucosal biopsies were taken for biochemical assessment of ADA, CAT, AND SOD activity and histological assessment. H. pylori density wAS evaluated according to the updated Sydney system. Patients were divided into three groups according to Sydney classification. ADA activity was found to be higher in patients having H. pylori in the present study. Also, ADA activity was higher in patients with a severe density of H. pylori. SOD level was found to be significantly higher with increased H. pylori density in our study (P < 0.05). In addition, SOD activity was higher in it H. Pylori-positive than H. pylori-negative patients. We did not find CAT activity in some antral tissue specimens. The significantly high levels of ADA activity in patients with H. pylori infection may reflect the regulator role of ADA in acid secretion. The higher ADA level with increased H. pylori density and H. pylori positivity indicate the probable malign lymphoid process of the stomach. But these findings must be confirmed with larger studies that include different gastric lesions.

Implications of antioxidant enzymes in human gastric neoplasms

“…In concordance with the present results, Götz et al (41) reported an increase in MnSOD activity and a slight decrease in Cu/ZnSOD in the inflamed gastric mucosa in HP-infected gastric patients, while Bulbuloglu et al (42) highlighted an increase in total SOD activity in patients with different states of HP infection, as confirmed by the absence of changes recorded in our HP-negative CG samples.…”

“…Tissue damage results from the cytotoxic effects of ammonia or the indirect effect of urease-induced stimulation of the inflammatory response, including recruitment of leukocytes, induction of proinflammatory cytokines, and triggering of an oxidative burst of neutrophils (42).…”

A Study of Oxidative Stress Parameters in Anti-Helicobacter Pylorus Immunoglobulin G Positive and Negative Gastric Cancer Patients

“…Some previous studies have reported that no CAT activity was found in most gastric juices, probably because of their low pH levels, and in some antral tissue specimens 41,42. Akcan, et al2 reported no unchanged of MPO and SOD activity in gastric mucosa of childhood period with HP (+) and (-) subjects, and Bulbuloglu, et al42 also reported no unchanged of CAT activity in antral mucosal between HP (+) and (-) subjects. In the present study, MPO and CAT activities were similar between the subjects included in the study.…”

“…Almost all the previous studies on the association of with HP in adult population were performed in gastric mucosa 12,21,23. Some previous studies have reported that no CAT activity was found in most gastric juices, probably because of their low pH levels, and in some antral tissue specimens 41,42. Akcan, et al2 reported no unchanged of MPO and SOD activity in gastric mucosa of childhood period with HP (+) and (-) subjects, and Bulbuloglu, et al42 also reported no unchanged of CAT activity in antral mucosal between HP (+) and (-) subjects.…”

Serum adenosine deaminase activity in cutaneous anthrax

“…High levels of serum ADA have been reported in infectious diseases such as viral and bacterial pneumonia, HIV infection, extra-pulmonary and pulmonary tuberculosis, H. pylori , acute appendicitis, visceral leishmaniasis, and mononucleosis [11,12,22,23] and might have diagnostic value. Moreover, circulating levels of ADA have been shown to increase in several inflammatory conditions, including Behçet’s disease, systemic lupus erythematosus, rheumatoid arthritis, and certain malignancies, especially those of hematopoietic origin [24–34].…”