Association of ADAM33 gene polymorphisms with psoriasis in a northeastern Chinese population

Abstract

Psoriasis (PS) is a common hyperproliferative and chronic inflammatory disease of the skin. It is influenced by both genetic and environmental factors. The ADAM33 (a disintegrin and metalloproteinase 33) gene located on chromosome 20p13, has recently been identified as an asthma-susceptibility gene by positional cloning. Recently, ADAM33 has been suspected to be associated with PS. To study the association between ADAM33 and PS in the northeastern Chinese population. A total of 240 PS patients and a control group of 237 healthy volunteers were recruited for this study. Five polymorphic loci (V4, T+1, T2, T1, S2) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction-restriction fragment length polymorphism method. We observed the frequency of the rs2787094 C allele was significantly higher in cases than in controls (50 vs. 33%, P < 0.0001).Similarly, the rs528557 C allele exhibited a significantly increased frequency in PS patients compared with healthy controls (35 vs. 21%, P < 0.0001). We also found that the frequencies of H3 (CGGAC), H6 (CGGGG) haplotypes were significantly higher in the case group than in the control group (P = 0.006, 0.028, respectively). In contrast, the haplotype H9 (GAAAG) was more common in the control group than in the case group (P = 0.018). Our data suggest that the ADAM33 polymorphisms may be associated with PS in the northeastern Chinese population.

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

“…Yu et al (2013) reported that the vitamin D/VDR pathway plays an important role in the development of KS. Han et al (2014) found that ADAM33 polymorphism may be associated with keloid scars in the northeastern Chinese population. Findings from another studies suggested the common genetic factors can predispose individuals to the development of KS (Zhu et al, 2013).…”

ADAM 33 gene V4 C/G rs2787094 polymorphism in psoriasis

“…Deng et al (17) observed a decreased frequency in CG and GG genotypes of ADAM33 rs2787094 (V4) in cases compared with controls, while V4 [rs2787094] was signifi cantly associated with psoriasis in the Chinese population (17). Han et al (18) showed that both V4[rs2787094] and S2[rs528557] SNPs were signifi cantly associated with psoriasis in a northeastern Chinese population, although V4[rs2787094] SNP was not signifi cantly associated with psoriasis in a French family-based study (16). A study reported that (19) ADAM33 rs597980 is associated with psoriasis in white North Americans.…”

Psoriasis: An Immunogenetic Perspective

“… 111 The frequency of the rs2787094 C allele of ADAM33 gene was significantly linked with psoriasis in a Han population. 112 The HCP5 gene 335 T> G polymorphism was associated with the increased risk of developing psoriasis in the Indian patients. 113…”