Association of Acute Radiation Syndrome and Rain after the Bombings in Atomic Bomb Survivors

Ozasa, Kotaro; Sakata, Ritsu; Cullings, Harry M.; Grant, Eric J.

doi:10.1667/rr14038.1

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…wooden house or concrete building), outside or unknown. Occurrence of acute radiation injuries (skin epilation that occurred within 2 months, oropharyngeal lesions that occurred within 2 months and flash burns produced by thermal radiation from the blast) was obtained from baseline surveys (1953)(1954)(1955)(1956)(1957)(1958)(1959)(1960)(1961), as in previous studies (Ozasa et al, 2016). Among not-in-city residents, time of entry into the cities was recorded from baseline surveys (1955)(1956)(1957)(1958)(1959)(1960)(1961) and categorised as early v. late entry (⩽30, >30 days).…”

Section: Measures Of Exposure Severitymentioning

confidence: 99%

Lifetime risk of suicide among survivors of the atomic bombings of Japan

Amano

French

Sakata

et al. 2021

Epidemiol Psychiatr Sci

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Aims The long-term physical health effects of the atomic bombings of Hiroshima and Nagasaki are well characterised, but the psychological effects remain unclear. Therefore, we sought to determine whether measures of exposure severity, as indirect measures of psychological trauma arising from exposure to the atomic bombings, are associated with suicide mortality among atomic bomb survivors. Methods The Life Span Study is a prospective cohort study of 93 741 Japanese atomic bomb survivors who were located within 10 km of the hypocentre in Hiroshima or Nagasaki at the time of the bombings in 1945, and 26 579 residents of Hiroshima and Nagasaki who were not in either city at the time of the bombings, matched to survivors on city, sex and age. Measures of exposure severity included: proximity to the hypocentre, type of shielding between the survivor and the blast and self-reported occurrence of acute radiation and thermal injuries. Date of death was obtained from the Japanese National Family Registry system. Cause of death was obtained from death certificates. Adjusted hazard ratios (HRs) were estimated from Cox regression models overall and stratified by sex and age. Results During the 60-year follow-up period (1950–2009), 1150 suicide deaths were recorded among 120 231 participants (23.6 per 100 000 person-years): 510 among 70 092 women (17.2 per 100 000 person-years) and 640 among 50 139 men (33.6 per 100 000 person-years). Overall, there was no association of proximity, type of shielding or the occurrence of acute injuries with suicide mortality. Among those <25 years of age at the time of the bombings, increased suicide risk was observed for survivors outside v. shielded inside any structure (HR: 1.24; 95% confidence interval (CI): 1.03, 1.48; interaction p = 0.054) and for those who reported flash burns (HR: 1.32; 95% CI: 1.00, 1.73; interaction p = 0.025). Sex-stratified analyses indicated that these associations were limited to men. Among women, closer proximity to the hypocentre was associated with a non-significant increase in suicide risk, with a positive association between proximity and suicide risk observed among women <15 years of age (HR: 1.09 per km; 95% CI: 1.00, 1.18; interaction p = 0.067). Conclusions Proximity to the hypocentre, shielding and acute injury presence do not generally appear to influence suicide mortality among atomic bomb survivors. However, heterogeneity may exist by age and sex, with younger survivors potentially more sensitive to psychological trauma. Coupled with other studies, our results suggest the importance of long-term monitoring of mental health among young populations exposed to catastrophic events or mass trauma.

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Section: Measures Of Exposure Severitymentioning

confidence: 99%

Lifetime risk of suicide among survivors of the atomic bombings of Japan

Amano

French

Sakata

et al. 2021

Epidemiol Psychiatr Sci

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“…3 Follow-up studies of mortality and incidence of cancer and prevalence of acute symptoms among those exposed to fallout rain did not indicate strong health effects according to exposure to residual radiation as a group, although adverse health effects among some distally-exposed individuals have been reported. 18 , 19 …”

Section: Building and Maintaining The Cohortmentioning

confidence: 99%

Japanese Legacy Cohorts: The Life Span Study Atomic Bomb Survivor Cohort and Survivors’ Offspring

Ozasa¹,

Grant

Kodama

2018

Journal of Epidemiology

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Cohorts of atomic bomb survivors—including those exposed in utero—and children conceived after parental exposure were established to investigate late health effects of atomic bomb radiation and its transgenerational effects by the Atomic Bomb Casualty Commission (ABCC) in the 1950s. ABCC was reorganized to the Radiation Effects Research Foundation (RERF) in 1975, and all work has been continued at RERF. The Life Span Study, the cohort of survivors, consists of about 120,000 subjects and has been followed since 1950. Cohorts of in utero survivors and the survivors’ children include about 3,600 and 77,000 subjects, respectively, and have been followed since 1945. Atomic bomb radiation dose was estimated for each subject based on location at the time of the bombing and shielding conditions from exposure, which were obtained through enormous efforts of investigators and cooperation of subjects. Outcomes include vital status, cause of death, and cancer incidence. In addition, sub-cohorts of these three cohorts were constructed to examine clinical features of late health effects, and the subjects have been invited to periodic health examinations at clinics of ABCC and RERF. They were also asked to donate biosamples for biomedical investigations. Epidemiological studies have observed increased radiation risks for malignant diseases among survivors, including those exposed in utero, and possible risks for some non-cancer diseases. In children of survivors, no increased risks due to parental exposure to radiation have been observed for malignancies or other diseases, but investigations are continuing, as these cohorts are still relatively young.

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“…Acute radiation syndrome occurred in hibakusha may be augmented by residual radionuclides with short half-life ( Sutou, 2017 ). Nevertheless, both acute radiation syndrome and long-term effects are reportedly not associated with the black rain which fell shortly after the bombing ( Sakata et al., 2014 ; Ozasa et al., 2016 ). Today about 200,000 A-bomb survivors are alive (Japanese Ministry of Health, Labour, and Welfare) and among them, about 53,000 are living in Nagasaki prefecture, Japan ( http://www.mhlw.go.jp/bunya/kenkou/genbaku09/15b.html browsed on Dec. 11, 2017).…”

Section: Introductionmentioning

confidence: 99%

Autoradiographic analysis of internal plutonium radiation exposure in Nagasaki atomic bomb victims

Shichijo

Takatsuji

Fukumoto

et al. 2018

Heliyon

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BackgroundRadiation doses received by Hiroshima and Nagasaki atomic bomb survivors has been evaluated from data related only to external exposure because there was no reliable evidence for internal exposure in atomic bomb victims. However, we assumed that the contribution of internal exposure cannot be ruled out.MethodsAutoradiography was carried out with the 70-year old paraffin-embedded specimens taken from Nagasaki atomic bomb victims who died within 5 months after the bombing. After exposure to photo emulsion for 6 months alpha-tracks were revealed in the specimens. We confirmed the alpha-tracks were emitted from deposited plutonium (Pu) in reference to the track length of the 8.787 MeV alpha-particle of thorium series from Polonium-212. Radioactivity concentration of Pu was obtained by counting alpha-tracks. The absorbed dose of each cell nucleus penetrated by an alpha-particle was estimated by calculating the absorbed energy from the particle.ResultsUsing old paraffin embedded sections processed about 70 years ago, we demonstrated for the first time that conditions in the aftermath of the bombing led to internal exposure to alpha-particles emitted from Pu, the fissile material of the Nagasaki atomic bomb. Dose rate of internal exposure was higher in the victims exposed outdoors than those indoors. Radioactivity concentration was relatively uniform among organs examined in a victim.ConclusionPu was deposited in the bodies of the Nagasaki A-bomb victims presumably via various routes. Organ dose from Pu of the Nagasaki A-bomb victims studied was during their surviving period, which is lower compared with external exposure. However, the impact to the individual cell nucleus by a single alpha-particle might not be negligible, It would be meaningful; to analyze the relationship of the impact of internal exposure at the cellular level and organ dose. The 70-year old pathological specimens utilized in our study are an invaluable source for understanding internal radiation exposure and are crucial in elucidating experimentally unreproducible phenomena.

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Association of Acute Radiation Syndrome and Rain after the Bombings in Atomic Bomb Survivors

Cited by 6 publications

References 15 publications

Lifetime risk of suicide among survivors of the atomic bombings of Japan

Lifetime risk of suicide among survivors of the atomic bombings of Japan

Japanese Legacy Cohorts: The Life Span Study Atomic Bomb Survivor Cohort and Survivors’ Offspring

Autoradiographic analysis of internal plutonium radiation exposure in Nagasaki atomic bomb victims

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