Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness

Matok, Ilan; Elizur, Arnon; Perlman, Amichai; Ganor, Shani; Levine, Hagai; Kozer, Eran

doi:10.1177/1060028016678006

Cited by 11 publications

(20 citation statements)

References 71 publications

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“…Of 3933 records identified, 3633 were excluded following title and abstract screening, 276 were excluded following full-text screening, and 4 were ongoing studies. Thus, 19 studies (20 publications 12 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ) were included ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

et al. 2020

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Key Points Question Are there differences in the antipyretic, analgesic, and safety profiles of acetaminophen (paracetamol) compared with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years? Findings In this meta-analysis of 19 studies with 241 138 participants, ibuprofen, compared with acetaminophen, was associated with reduced temperature at less than 4 hours and 4 to 24 hours and less pain at 4 to 24 hours. Adverse events were uncommon. Meaning In this study, use of ibuprofen vs acetaminophen for the treatment of fever or pain in children younger than 2 years was associated with reduced temperature and less pain within the first 24 hours of treatment, with equivalent safety.

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Section: Resultsmentioning

confidence: 99%

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

et al. 2020

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“…It may be argued that a single dose of paracetamol is rather harmless. Still, there are reports of adverse effects, and it is an open question whether perfunctory use of analgesics in dentistry should be acceptable.…”

Section: Discussionmentioning

confidence: 99%

“…The placebo effect, however, should not be underrated, but perhaps an active substance should not be used for this purpose. Whereas both paracetamol and ibuprofen are widely used for children and adolescents to fight fever and pain, some studies have reported an increased risk of exacerbation of asthma symptoms in children taking paracetamol or ibuprofen. Both pharmaceutical substances also seem to enhance the risk of liver damage in children.…”

Section: Discussionmentioning

confidence: 99%

Dentists' attitudes towards acute pharmacological pain management in children and adolescents

Berlin

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Ridell

et al. 2017

Int J Paed Dentistry

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“…Thus, there is hardly any evidence for analgesic use, pre-or postoperatively, to reduce pain after uncomplicated dental treatment in children; this remains a knowledge gap. Based on this, and the fact that all administration of pharmacologic agents comes with a risk (Matok et al 2016;Norman et al 2014), it can be questioned if there is any reason for clinical guidelines in this area. Analogously, there is no rationale for introducing or routinely using administration of analgesics in conjunction with routine dental treatments such as filling therapies or uncomplicated extractions (Berlin et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Postoperative pain profile in 10–15-year-olds after bilateral extraction of maxillary premolars

Berlin

List

Ridell

et al. 2019

Eur Arch Paediatr Dent

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Purpose To study pain perception in 10-15-year-olds, during and after uncomplicated extractions of bilateral maxillary premolars. The study investigated pain's natural course and made comparisons between the first and second extractions. Methods 31 Swedish children in need of orthodontic treatment were identified and consecutively enrolled. Tooth extractions followed a standardised protocol and the two teeth were extracted with at least 10 days between. The participants rated pain intensity using visual analogue scale (VAS) at 14 different time points from treatment and 7 days forward. Results The pain intensity profile followed the same pattern for all patients. Pain intensity peaked 2 h after extractions (mean VAS PI 27.3, SD 20.8; median 23.0) when moderate pain intensity (VAS PI ≥ 40) was registered for 16 (28%) of 57 cases. After that, there was a rapid decrease in pain intensity notable already at 4 h after extractions. There were no statistically significant differences in any VAS PI measurements between the first and second extractions, sexes, or different age groups. Conclusions The majority of the participants who undergo uncomplicated bilateral extraction of maxillary premolars experience mild to moderate levels of postoperative pain during a short period of time, with no differences between the first and second extractions. Bilateral tooth extractions is a suitable model for further studies on pain management.

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Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness

Abstract: Our study suggests that acetaminophen and ibuprofen are not associated with increased risk for wheezing during acute febrile illness.

Cited by 11 publications

References 71 publications

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Dentists' attitudes towards acute pharmacological pain management in children and adolescents

Postoperative pain profile in 10–15-year-olds after bilateral extraction of maxillary premolars

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