Association of ACE I/D polymorphism in Tunisian patients with dilated cardiomyopathy

Abstract

Primary cardiomyopathies are multifactorial diseases. Genetic factors other than the causal mutations in the modified genes affect the phenotypic expression of dilated cardiomyopathy. The aim of this study was to determine the association of angiotensinconverting enzyme I/D polymorphism with the risk of dilated cardiomyopathy in a Tunisian population. A total of 76 patients with dilated cardiomyopathy was compared to 151 ethnically, age-and gender-matched controls. The frequencies of the DD genotype and D allele were significantly higher in patients as compared with controls, and were associated with increased risk of dilated cardiomyopathy (ACE DD versus ID and II: OR = 3.05 (95% CI, 1.58-5.87; p = 0.001)); D versus I: OR = 2 (95% CI: 1.35-2.97; p = 0.001)). No association was found between the combined genotypes (DD+ID) or D allele and left ventricular end diastolic diameter in dilated cardiomyopathy patients with severe and moderate clinical phenotypes. DD genotype and D allele of angiotensin-converting enzyme I/D gene polymorphism are associated with increased risk of dilated cardiomyopathy in a Tunisian population but do not influence the cardiac phenotype severity.

Molecular Characterization of Phospholamban and Reninangiotensin System Genes Mutations and Clinical Epidemiology in Human Cardiomyopathy

“…The D allele compared with I allele has more than percent increased risk to cardiomyopathy. On comparison, the prevalence of D allele in the present study (Indian population) was slightly higher (about 60%) than Tunisian and Turkish populations (47,48). Association of DD genotype / D allele with HCM and DCM have been reporting in many studies (49,50) and the polymorphism considered as a modifier gene marker to cardiomyopathy.…”

Angiotensin-Converting Enzyme Genetic Polymorphism: Its Impact on Cardiac Remodeling

“…The short interval between exams (only three months after optimization of the BB dose as compared to 65.5 months in this study) might have been insufficient to observe cardiac reverse remodeling in that study. Mahjoub et al 17 have not detected echocardiographic differences between the GPACEs, but those authors have chosen a categorical analysis, dividing the sample into two groups according to the LVDD (≥ 69 mm versus < 69 mm), corresponding to higher or lower severity, respectively. The statistical analysis of the present study used the numerical values of the echocardiographic parameters as continuous variables, having, thus, higher discriminatory power.…”

A study on the polymorphisms of the renin–angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria

“…It was similar to that observed in Omanis (71%) or Somalis (73%), and higher than in Sudanese (64%), Emirati Arab (61%), 19 Egyptian (67%), Jordanian (66%) or Syrian populations (60%). 20 The D allele frequency was also lower in Blacks (60%), 15 in Caucasians (56%), 15 in Tunisians (42%), 21 and even more in Asians (39%). 15 No effect of AGT polymorphisms on SBP, DBP, or PP can be shown in the present study.…”