Association of ACE genotype and predominantly diastolic hypertension: a preliminary study

Jiménez, Pablo; Conde, Cecı́lia; Casanegra, Ana I.; Romero, César A; Tabares, Aldo; Orías, Marcelo

doi:10.3317/jraas.2007.006

Cited by 30 publications

(24 citation statements)

References 20 publications

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“…Our results are concordant with those of Jiménez et al [64] who reported on the association between the DD genotype and predominantly diastolic hypertension. Increased blood pressure in homozygous subjects for the D allele could contribute to a more severe clinical course and a steeper development of end-stage renal disease.…”

Section: Discussionsupporting

confidence: 94%

Angiotensin-Converting Enzyme Gene Polymorphism and N-Acetyl-β-<i>D</i>-Glucosaminidase Excretion in Endemic Nephropathy

et al. 2011

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Background: Tubular proteinuria and enzymuria are hallmarks of endemic nephropathy (EN). The role of I/D angiotensin convertase (ACE) gene polymorphism has not yet been elucidated in this peculiar chronic tubulointerstitial nephritis, and our aim was to investigate the role of this polymorphism in EN focusing on the urinary N-acetyl-β-D-glucosaminidase (NAG) excretion, a biomarker of proximal tubular damage. Methods:ACE genotype and allele frequencies were determined in 229 farmers (147 women and 82 men) from an endemic Croatian village. The farmers were stratified according to the WHO criteria into the following subgroups: those ‘at risk’ for EN (n = 37), ‘suspected of having EN’ (n = 57), and ‘others’ (n = 135). Results: There were 74 (32.3%) subjects homozygous for the D allele, 99 (43.2%) heterozygous (ID genotype) and 56 (24.4%) homozygous for the I allele. No differences in allele frequency were found between the established WHO subgroups (p > 0.05). In the whole group, DD subjects had significantly higher values of diastolic blood pressure (p = 0.003) and urinary NAG than subjects with ID and II genotype (5.5 ± 1.2 vs. 4.0 ± 3.0 vs. 3.8 ± 4.2, respectively; p = 0.023). The highest values of serum creatinine (p = 0.02), proteinuria (p = 0.03) and urinary NAG (6.0 ± 3.7 vs. 3.7 ± 2.1 vs. 3.0 ± 1.6, respectively; p = 0.008) were observed in those suspected of having EN group with the DD genotype. Conclusion:ACE gene polymorphism is not a risk factor for EN. However, it might influence the clinical course of EN, and increased excretion of NAG might be a prognostic marker of this chronic tubulointerstitial nephritis.

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Section: Discussionsupporting

confidence: 94%

Angiotensin-Converting Enzyme Gene Polymorphism and N-Acetyl-β-<i>D</i>-Glucosaminidase Excretion in Endemic Nephropathy

et al. 2011

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“…Some explain this inconsistency with genetic and environmental heterogeneity between different ethnic groups (Bautista et al 2004;Zhang et al 2007;Higaki et al 2000;Jiménez et al 2007;Companioni Nápoles et al 2007) as well as ACE I/D polymorphism gene's complex interaction with other genetic factors that contribute to the expression of HT (Nawaz and Hasnain 2008).…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans

Petranović

Škarić‐Jurić

Narančić

et al. 2011

AGE

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The human angiotensin converting enzyme (ACE) gene is one of the most investigated candidate genes for cardiovascular diseases (CVD), but the understanding of its role among the elderly is vague. Therefore, this study focuses at: (a) testing the association of ACE polymorphism with CVD risk factors among the elderly, and (b) detecting the possible unequal distribution of ACE genotypes between senescent and younger segments of the European populations. The association of ACE I/D polymorphism with CVD health status [hypertension (HT), obesity, dislypidemia] in 301 very old subjects (88.2±5 years; F/M=221/80) was tested by means of logistic regression analysis. The meta-analysis of D allele frequency in general vs. elderly (80+ years) groups was conducted using all publicly available data for European populations comprising both age cohorts. Multiple multinomial logistic regression revealed that within this elderly sample, age (younger olds, 80-90 years), female sex (OR=3.13, 95% CI= 1.59-6.19), and elevated triglycerides (OR=2.53, 95% CI=1.29-4.95) were positively associated with HT, while ACE polymorphism was not. It was also established that the DD genotype was twice as high in 80+ cohort compared to general population of Croatia (p<0.00001). This trend was confirmed by the metaanalysis that showed higher D allele frequencies in olds from nine of ten considered European populations (OR=1.19, 95% CI=1.08-1.31). The data in elderly cohort do not confirm previously reported role of ACE DD genotype to the development of HT. Moreover, meta-analysis indicated that ACE D allele has some selective advantage that contributes to longevity in majority of European populations.

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“…3 Furthermore, it is assumed that the reninangiotensin-aldosterone system is part of a pathway implicated in the pathogenesis of different pregnancy complications. 4 In particular, the intron 16 insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE), which critically influences plasma ACE activity 5,6 and angiotensin peptide levels, 7 and which is implicated in the pathogenesis of different diseases, 8,9 is discussed as a possible genetic risk factor for pre-eclampsia. 10,11 Moreover, there are a few studies indicating a possible influence of the ACE I/D genotype on risk of foetal loss (FL) under certain circumstances.…”

Section: Introductionmentioning

confidence: 99%

Association of angiotensin-converting enzyme intron 16 insertion/deletion polymorphism with history of foetal loss

Bukreeva

Grigorov

Kiesewetter

et al. 2009

J Renin Angiotensin Aldosterone Syst

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Introduction. The angiotensin-converting enzyme (ACE) intron 16 insertion/deletion (I/D) polymorphism is associated with ACE activity and has been discussed as a risk factor for pre-eclampsia. Disturbances of uteroplacental circulation are involved in the pathogenesis of pre-eclampsia. In this study, we tested whether the ACE I/D genotype is associated with history of foetal loss (FL) or uteroplacental dysfunction (UPD). Patients and methods. ACE I/D genotype was determined in 312 women presenting with a history of FL and 112 women admitted because of UPD. The association of the ACE I/D genotype with FL or UPD was assessed in a case-control study using 527 patients with diagnoses other than FL or UPD. To exclude potential biases due to associations of this genotype with other diagnoses, we additionally performed a casecontrol study using 553 healthy controls. Results. ACE I/D genotype was significantly associated with history of FL in both case-control studies (patient controls: odds ratio 1.52, p<0.02; healthy controls: odds ratio 1.48, p=0.02). There was no evidence for allele-dose dependency. No association of the ACE I/D genotype with UPD could be detected. Conclusions. The ACE I/D genotype exhibits a statistically significant association with a history of FL. These results corroborate an involvement of the renin-angiotensin system in pregnancy complications.

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Association of ACE genotype and predominantly diastolic hypertension: a preliminary study

Cited by 30 publications

References 20 publications

Angiotensin-Converting Enzyme Gene Polymorphism and N-Acetyl-β-<i>D</i>-Glucosaminidase Excretion in Endemic Nephropathy

Angiotensin-Converting Enzyme Gene Polymorphism and N-Acetyl-β-<i>D</i>-Glucosaminidase Excretion in Endemic Nephropathy

Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans

Association of angiotensin-converting enzyme intron 16 insertion/deletion polymorphism with history of foetal loss

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