Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS-13 in patients with lung cancer

Liu, Xia; Chen, Xiaogang; Yang, Jiezuan; Guo, Renyong

doi:10.3892/ol.2017.6619

Cited by 19 publications

(25 citation statements)

References 33 publications

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“…24 Our results are also supported by previously published studies in which the non-O blood group members have been shown to have greater concentrations of Von Will brand clotting factors. 25,26 Since high cholesterol and high concentration of Von will brand factors in blood type A population (a non-O blood group) puts a person at higher risk of stroke and it is reasonable to assume that the patients of A blood group in Saudi adult population are at higher risk of stroke as suggested by our results in this study. In the current study as expected, we also found a high prevalence of smoking however we found high prevalence of smoking not only in control subjects but also in male stroke patients (Tables 1 and 2).…”

Section: Discussionmentioning

confidence: 78%

Haemorrhagic stroke in Saudi adult male population and the ABO blood group distribution: a comparative analysis

Farshori

Alrashdan

Alshammari

2020

Int J Community Med Public Health

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Background: Globally stroke is leading cause of death and disability. According to WHO every year 15 million people get stroke and one third of these subjects die and about 5 million become permanently disabled. In SA smoking, diabetes, and hypertension are highly prevalent and since these factors are among ten major risk factors for stroke it puts Saudi population at higher risk of stroke. In current study we studied prevalence of hemorrhagic (HS) stroke and analyzed if there is any correlation between incidences of HS and ABO blood groups in Saudi population.Methods: Blood groups and other relevant data were collected for 2304 stroke patients registered at King Khaled hospital between 1/1/2008 to 1/6/2018. Statistical analysis was performed using Z calculator.Results: We saw 5.4-fold increase in prevalence of diabetes type 2 and 8.7 fold increase in prevalence of hypertension among HS patients as compared to control subjects. Prevalence of smoking was higher in both control and HS patients. 21.7% of stroke patients were HS patients. Distribution of A blood group was significantly higher in male HS patients. AB blood group showed statistically significant reduction in HS patients as compared to control group. Results were statistically significant at (p˂0.01). However, blood group B and O showed no significant differences between two groups.Conclusions: Results of our studies show a correlation between ABO and the incidences of hemorrhagic stroke in Saudi adult male population. Larger studies are needed to confirm these results.

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Section: Discussionmentioning

confidence: 78%

Haemorrhagic stroke in Saudi adult male population and the ABO blood group distribution: a comparative analysis

Farshori

Alrashdan

Alshammari

2020

Int J Community Med Public Health

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“…45 Furthermore universal donor type O required for early transfusion of WB, has lower factor VIII activities compared to other blood groups. 46 In clinical practice these small differences in coagulation factor activity will probably have minimal impact on the clinical outcome of patients with major hemorrhage. The reduction of plasma in PAS stored platelets may have a significant effect compared to platelets stored in plasma in this patient category, though this has yet to be shown.…”

Section: Discussionmentioning

confidence: 99%

Prolonged (post‐thaw) shelf life of −80°C frozen AB apheresis plasma

Rijnhout

Noorman²,

Kort³

et al. 2020

Transfusion

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BACKGROUND: Early plasma transfusion is important in the treatment of patients with major hemorrhage. Prolonged shelf life of AB type frozen −80°C and coldstored (4°C) deep frozen plasma (DFP) will improve strategic stock management, minimize need for resupply, and make pre-hospital implementation more feasible. METHODS AND MATERIALS: Plasma products type AB of different age and origin (−30°C Fresh Frozen [(FFP], −80°C DFP [short (AE1 year) and long (AE7 year)] stored) were thawed (Day 0), stored at 4°C, and sampled on Days 7 and 14. Additionally, samples of plasma containing blood products (Octaplas LG ® , whole blood and platelets) were compared for coagulation factor activity, phospholipid clotting time (PPL), and kaolin TEG during 4°C or 22°C storage. RESULTS: Coagulation profiles of FFP, short-and longstored −80°C DFP were not significantly different after thaw. Cold storage did not affect fibrinogen, Protein C, and Antithrombin III activities whereas factor V, VII, VIII, and Protein S decreased in all blood products. After 14 days DFP still meets the guidelines for clinical use, except for Protein S (0.4 IU/mL). With exception of Octaplas LG ® , phospholipid activity and TEG coagulation were similar between plasma containing blood components during storage. CONCLUSION: AB DFP quality was unaffected by almost 7 years of frozen storage. Quality of thawed 14day stored AB DFP met, with exception of Protein S, all minimal guidelines which implies that its quality is sufficient for use in the (pre)-hospital (military) environment for treatment of major hemorrhage.

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“…Several plausible mechanisms could account for the association between ABO blood group antigens and cancer development and progression (3,(8)(9)(10). Glycosyltransferase is encoded by the ABO gene located on chromosome 9q34.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in the enzymatic activity of ABO glycosyltransferase play an important role in the activation of adhesion molecules, intracellular signaling, and determination of the level of von Willebrand factor (VWF), thereby affecting tumor growth and spread (3,(8)(9)(10). VWF is a multimeric glycoprotein, which is synthesized in endothelial cells, and is one of several platelet adhesion ligands that could potentially modulate cancer development and metastasis (3,8). The VWF antigen level in adults is, on average, about 25% to 30% lower in blood group O individuals than in non-O individuals (26,27).…”

Section: Discussionmentioning

confidence: 99%

The ABO Blood Group Impacts the Survival of Patients Undergoing Pancreatoduodenectomy for Biliary Tract Cancer

Mori

Aoki

Tago

et al. 2020

In Vivo

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Background/Aim: Although ABO blood group has been reported to be associated with the outcome of patients with pancreatic cancer, little is known about its impact on patients with biliary tract cancer (BTC). We evaluated the prognostic relevance of ABO blood group in patients who had undergone resection of BTC. Patients and Methods: A total of 154 patients with BTC undergoing pancreatoduodenectomy were retrospectively reviewed. Associations between ABO blood group and patient survival were evaluated by univariate and multivariate analysis. Results: The 5-year overall survival rate was higher in group O patients (n=46) than in other blood group patients (n=108) (65.8% vs. 47%, p=0.005). Multivariate analysis revealed that a non-O blood group was an independent risk factor for poor survival (p=0.021). Conclusion: ABO blood group is associated with the prognosis of patients with resected BTC; group O patients have a better outcome. The ABO blood group antigens are the most important alloantigens among the human blood group systems, being expressed not only on red blood cell membranes but also on the surfaces of several other cell types and tissues (1-3). The association between ABO blood group and cancer has been studied by a number of investigators since the mid-1900s (4-7); and several plausible mechanisms have been proposed to explain this association, including inflammation, immune response, intercellular adhesion, and cellular membrane signaling (3, 8-10). In fact, the influence of ABO blood group has been reported in various types of malignancy, including cancers of the gastrointestinal tract, urinary tract, respiratory tract, and breast (3, 6). In the pancreato-biliary field, a lower incidence of pancreatic cancer in blood group O individuals was revealed in a two-stage genome-wide association study (GWAS) (11). Some studies have also suggested that blood group O confers a more favorable prognosis than non-O blood groups in patients with pancreatic cancer (12, 13). With regard to biliary tract cancer (BTC), it remains unclear if ABO blood group impacts the clinical outcome. Because BTC is a relatively rare malignancy (14-16), the relationship between blood groups and outcome might be difficult to assess because of the small number of cases. Therefore, the aim of this study was to investigate the associations between the ABO blood groups and outcomes of patients with BTC who had undergone pancreatoduodenectomy (PD), and whether blood group O is associated with a favorable prognosis.

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Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS-13 in patients with lung cancer

Cited by 19 publications

References 33 publications

Haemorrhagic stroke in Saudi adult male population and the ABO blood group distribution: a comparative analysis

Haemorrhagic stroke in Saudi adult male population and the ABO blood group distribution: a comparative analysis

Prolonged (post‐thaw) shelf life of −80°C frozen AB apheresis plasma

The ABO Blood Group Impacts the Survival of Patients Undergoing Pancreatoduodenectomy for Biliary Tract Cancer

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