Abstract:The human nuclear pregnane X receptor (PXR;NR1I2) which regulates the expression of ABCB1 gene which encodes phosphoglycoprotein, an efflux pump for carbamazepine (CBZ). The aim of this study was to investigate whether ABCB1 C3435T and NR1I2 A7635G variants significantly impact the response of epilepsy patients to CBZ monotherapy. ABCB1 C3435T and NR1I2 A7635G genotyping were performed on 168 Malaysian epilepsy subjects (76 drug‐responsive and 92 drug‐resistant) receiving CBZ monotherapy by PCR‐RFLP. The resul… Show more
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