Association of a polymorphism in PON-1 gene with steroid-induced osteonecrosis of femoral head in Chinese Han population

Abstract

BackgroundTreatment with steroids covers a wide spectrum of diseases in clinic. However, some users are suffering from serious side effects of steroid administration, while we enjoy the benefit it brings about. Osteonecrosis of the femoral head (ONFH) is a troublesome one among them. Recent studies have demonstrated that lipid metabolism disorder may play a vital role in pathogenesis of ONFH and mutation of the paraoxonase-1 (PON-1) gene may be involved in the occurrence of this disease. However, the relationship between polymorphisms of PON-1 and ONFH has not been thoroughly studied. The aim of this study was to determine whether PON-1 polymorphisms are associated with steroid-induced ONFH through a cohort study among Chinese Han population.MethodsThis trial applied a case–control scheme to compare the clinical data including PON-1 SNP among 94 patients and 106 control subjects to analyze the association between SNP and risk of steroid-induced ONFH. Time of Flight Mass Spectrometer is utilized for genotyping and the result was analyzed in multivariate analysis models.ResultsAccording to polymorphism test of rs662, its SNP was significantly associated with the risk of ONFH in overdominant analysis model [P value: 0.022; odds ratio (OR): 0.39]. However, genotype frequencies of rs662 of PON-1 gene between case and control group showed no differences (P > 0.05).ConclusionsOur data suggest for the first time that SNP (rs662) of the PON-1 gene was associated with the risk of steroid-induced ONFH. In addition, PAI-1 SNPs may play an important role in pathogenesis of ONFH.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/1501829501107336.

The genetic association between PON1 polymorphisms and osteonecrosis of femoral head

“…In 2007, Hadjigeorgiou et al [ 25 ] researched the role of PON1 polymorphisms in ONFH with/without WML in Greek population and the common polymorphisms M55L, R192Q were selects, the results indicated that PON1 192QQ genotype carriers had a significant increased risk to suffer from ONFH and WML, but not M55L polymorphism. In Chinese Han population, Wang et al [ 26 ] conducted a case-control study about PON1 rs662 (R192Q) polymorphism and ONFH risk and also gained a similar conclusion that rs662 was associated with the susceptibility to steroid-induced ONFH. However, the steroid users without developing ONFH were employed as control.…”

Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism

“…Environmental factors include type of prosthesis, implant design, material, surgical technique, fixation method, and postoperative rehabilitation procedure have been widely studied [ 13 , 14 ], but more and more attention is paid to the genetic factors like single nucleotide polymorphisms (SNPs). SNPs are genetic variations that are considered biologically normal and can be found in at least 1% of the population, which may contribute towards individual susceptibilities to certain pathological conditions [ 15 , 16 ]. Various gene SNPs of GNAS1, TNF-238, TNF-a, IL6-174, MMP1, MMP2, and et al were reported to be associated with increased prosthetic loosening.…”

Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population

“…ONFH is a disorder caused by the interactions with complex genetic and environmental factors 9 . A series of genes polymorphisms have been showed to associate with ONFH risk 10 , 11 , 12 while the effects of genes polymorphisms in RANKL/RANK/OPG signaling pathway on the development of ONFH have been remained unclear. RANK/RANKL/OPG pathway plays an important role in the pathogenesis of RA and osteoporosis due to the crucial molecular pathway for coupling between osteoblasts and osteoclasts.…”