2010
DOI: 10.1016/j.biopsych.2009.10.015
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Association of a Polyadenylation Polymorphism in the Serotonin Transporter and Panic Disorder

Abstract: Background-Genetic markers in the serotonin transporter are associated with panic disorder. The associated polymorphisms do not include the serotonin transporter-linked polymorphic region and display no obvious functional attributes. A common polymorphism (rs3813034) occurs in one of the two reported polyadenylation signals for the serotonin transporter and is in linkage disequilibrium with the panic disorder-associated markers. If functional, rs3813034 may be the risk factor that explains the association of t… Show more

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Cited by 56 publications
(81 citation statements)
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“…In contrast, mice lacking SERT do not display enhanced fear extinction learning with CR, suggesting SERT has a crucial role in mediating this effect of CR. We also found that CR phenocopies the effects of fluoxetine on fear extinction learning, and the expression of a SERT mRNA species that we previously associated with decreased anxiety states and enhanced fear extinction retention (Gyawali et al, 2010;Hartley et al, 2012). We discuss how these results may be relevant to anorexia nervosa, an eating disorder characterized by both high levels of anxiety and caloric restriction (CR).…”
Section: Introductionmentioning
confidence: 55%
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“…In contrast, mice lacking SERT do not display enhanced fear extinction learning with CR, suggesting SERT has a crucial role in mediating this effect of CR. We also found that CR phenocopies the effects of fluoxetine on fear extinction learning, and the expression of a SERT mRNA species that we previously associated with decreased anxiety states and enhanced fear extinction retention (Gyawali et al, 2010;Hartley et al, 2012). We discuss how these results may be relevant to anorexia nervosa, an eating disorder characterized by both high levels of anxiety and caloric restriction (CR).…”
Section: Introductionmentioning
confidence: 55%
“…Total SERT, distal SERT, and control gene (glyceraldehyde 3-phosphate dehydrogenase, Beta-glucuronidase, hypoxanthine phosphoribosyltransferase 1, and TATA binding protein) mRNA levels were measured in separate reactions via an ABI 7900HT real time-PCR thermal cycler using SYBR green detection of amplified fragments (Gyawali et al, 2010). Samples were reverse transcribed twice and each cDNA sample analyzed in quadruplicate.…”
Section: Quantitative Pcrmentioning
confidence: 99%
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“…We have reported that expression of the longer, or distal, polyadenylation form of the SERT mRNA confers anxiolytic properties on behavior (11,12). Specifically, males express higher levels of the distal polyadenylation form of SERT than females, who display a two-to threefold higher risk for anxiety disorders than males; a common polymorphism that is associated with expression of the SERT polyadenylation forms in human postmortem brain is also associated with risk for panic disorder, trait anxiety, and the ability of human subjects to retain fear extinction learning, a validated endophenotype of anxiety and its disorders (11,12). Finally, treatment of mice with the SERTselective antidepressant/anxiolytic drug fluoxetine, which has also been shown to enhance fear extinction retention, increases expression of the distal polyadenylation form of SERT (12,13).…”
mentioning
confidence: 99%