Association of a functional BDNF polymorphism and anxiety-related personality traits

Lang, Undine E.; Hellweg, Rainer; Kalus, Peter; Bajbouj, Malek; Lenzen, Kirsten P.; Sander, Thomas; Kunz, Dieter; Gallinat, Jürgen

doi:10.1007/s00213-004-2137-7

Cited by 265 publications

(180 citation statements)

References 44 publications

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“…20 In studies with respect to personality traits, the C allele was associated with anxiety-related personality traits, such as higher mean neuroticism scores in the NEO-FFI, 21 and higher levels of trait anxiety in the STAI. 22 Interestingly, the frequency of the T allele in the Japanese and other Asian populations (approximately 41%) was significantly higher than that (approximately 18%) in Caucasians. 23 Thus far, two genetic association studies investigated this variant of the BDNF gene in PD, which observed no significant association in the Japanese or Chinese population.…”

Section: Introductionmentioning

confidence: 87%

No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population

et al. 2009

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Panic disorder (PD) is a severe and chronic psychiatric disorder, with significant genetic components in the etiology. Brain-derived neurotrophic factor (BDNF) gene, which has regulatory effects on neurotransmitter systems such as serotonin and dopamine, is a candidate for susceptibility locus of PD. This study investigated three single-nucleotide polymorphisms (SNPs) of BDNF (rs6265 (Val66Met), rs11030104 and rs7103411) in Japanese patients with PD and controls. No significant association was observed between the three SNPs and PD. No association of the Val66Met was consistent with two small studies in Japanese and Chinese populations. We therefore conclude that the BDNF polymorphism may not play a major role in PD in the East Asian populations. Keywords: brain-derived neurotrophic factor; genetic association; Japanese population; panic disorder; Val66Met polymorphism INTRODUCTION Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety, with a lifetime prevalence of 1-3% and a female/male ratio of 2:1. 1 PD frequently takes a chronic course, with many remissions and relapses, occasionally complicated by comorbidity with other psychiatric disorders, such as agoraphobia and major depression. 2 It is generally accepted that PD has genetic as well as environmental causes. A 2.6-to 20-fold relative risk in the firstdegree relatives of proband with PD compared with the general population suggests a familial component in this disorder. 3,4 Twin studies show that about 40% of the liability toward PD consists of heritable factors. 5-7 Thus far however, the etiology of PD is currently unknown.Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, promotes the survival, differentiation and maintenance of a broad variety of central nervous system neurons. 8,9 BDNF has regulatory effects on multiple neurotransmitter systems, including serotonin 10 and dopamine, 11 and maybe involved in the etiology of stress-related disorders, such as depression and PTSD. Chronic administration of antidepressants, including selective serotonin reuptake inhibitors, increases BDNF expression in the hippocampus. 12 On the other hand, animal studies support the fact that environmental stressors, such as immobilization, decreased central

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Section: Introductionmentioning

confidence: 87%

No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population

et al. 2009

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“…In a recent study, Kaufman et al found that children carrying the met allele of the BDNF gene val66met polymorphism and two short alleles (s/s) of 5-HTTLPR had the highest depression scores, but that this vulnerability was only evident in children with maltreatment history (Kaufman et al, 2006). This result is somewhat surprising, because most reports studying the val66met polymorphism have suggested that the met allele is protective for anxiety (Lang et al, 2005;Hunnerkopf et al, 2007) depression (Schumacher et al, 2005;Strauss et al, 2005;Frodl et al, 2007), but see Jiang et al (2005), and bipolar disorder (Neves-Pereira et al, 2002;Sklar et al, 2002). Indeed, in a separate study, the prevalence of depression due to multiple life events was found to be dramatically increased in s/s elders with one met allele (Kim et al, 2007).…”

Section: Genetic Epistasismentioning

confidence: 99%

Interaction between BDNF and Serotonin: Role in Mood Disorders

Martinowich

2007

Neuropsychopharmacol

676

458

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Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

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“…[24][25][26][27][28][29] Further evidence implicating the BDNF locus' involvement in mood disorders arises from studies of neuroticism, a trait highly correlated with depression. [30][31][32][33] We have recently described an association between the BDNF (GT) n marker and a haplotype containing the Val 66 Met val allele with COMD in 93 case-control pairs. 34 Overall, substantial reason exists to further examine BDNF as a candidate gene for depressive disorders such as COMD.…”

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Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample

et al. 2005

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Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has been implicated in the neurobiology of depression. Our group has previously reported an association between a BDNF variant and childhood-onset mood disorder (COMD) in an adult sample from Pittsburgh. We hypothesize that variants at the BDNF locus are associated with COMD. Six BDNF polymorphisms were genotyped in 258 trios having juvenile probands with childhood-onset DSM-IV major depressive or dysthymic disorder. Keywords: neurotrophic factors; mood disorder; childhood-onset; genetic association; haplotype Mood disorders rank fourth among the most significant global public health problems. 1 The prevalence of the juvenile-onset subtype of depressive disorder increases dramatically across the years of childhood and adolescence, with an estimated lifetime prevalence close to 20% by late adolescence. 2 Juvenile-onset mood disorders are associated with serious morbidity, including recurrence, impaired interpersonal functioning, and increased risks of bipolar disorder and suicide. 2,3 The influence of hereditary factors on susceptibility to major depression has been documented based on twin and adoption studies. 4 Twin studies in youth have identified significant heritability for depressive symptoms. 5,6 It has also been proposed that genetic aspects of liability to mood disorder may be more readily identified in families of childhood-and adolescentonset probands. 7 Accordingly, first-degree relatives of childhood-onset mood disorder probands have higher rates of affective disorder than do first-degree relatives of adult-onset mood disorder probands. 8 Evidence from both preclinical and clinical studies implicates brain-derived neurotrophic factor (BDNF) in mood disorders. Altered BDNF expression in stress-related depression via cellular signalling has been described in animal models. Repeated antidepressant administration, including electroconvulsive seizures, is associated with increased hippocampal BDNF expression, neuronal plasticity and neurogenesis. 9-11 Human neuroimaging 12,13 post mortem 14 and clinical [15][16][17] investigations indirectly support the hypothesis that neurotrophic factors play a key role in depression. As well, human linkage studies in

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Association of a functional BDNF polymorphism and anxiety-related personality traits

Abstract: Our findings support the hypothesis that anxiety- and depression-related personality traits are associated with the BDNF polymorphism although the explained variance is low.

Cited by 265 publications

References 44 publications

No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population

No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population

Interaction between BDNF and Serotonin: Role in Mood Disorders

Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample

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