Association of a Common Genetic Factor, <i>PTGER3</i>, With Outcome of Periodontal Therapy and Preterm Birth

Jeffcoat, Robert L.; Tanna, Nipul; Parry, Samuel

doi:10.1902/jop.2013.130006

Cited by 19 publications

(11 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PTGER3 is a gene associated with inflammatory response and plays a role in initiation of labor. However, another study found an increased risk of PTB in women with SNP in PTGER3 [ 44 ]. Polymorphisms in prostaglandin D receptor ( PTGDR ) also increased the risk of post-coital preterm birth in women [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

et al. 2016

View full text Add to dashboard Cite

BackgroundPreterm birth (PTB), birth at <37 weeks of gestation, is a significant global public health problem. World-wide, about 15 million babies are born preterm each year resulting in more than a million deaths of children. Preterm neonates are more prone to problems and need intensive care hospitalization. Health issues may persist through early adulthood and even be carried on to the next generation. Majority (70 %) of PTBs are spontaneous with about a half without any apparent cause and the other half associated with a number of risk factors. Genetic factors are one of the significant risks for PTB. The focus of this review is on single nucleotide gene polymorphisms (SNPs) that are reported to be associated with PTB.ResultsA comprehensive evaluation of studies on SNPs known to confer potential risk of PTB was done by performing a targeted PubMed search for the years 2007–2015 and systematically reviewing all relevant studies. Evaluation of 92 studies identified 119 candidate genes with SNPs that had potential association with PTB. The genes were associated with functions of a wide spectrum of tissue and cell types such as endocrine, tissue remodeling, vascular, metabolic, and immune and inflammatory systems.ConclusionsA number of potential functional candidate gene variants have been reported that predispose women for PTB. Understanding the complex genomic landscape of PTB needs high-throughput genome sequencing methods such as whole-exome sequencing and whole-genome sequencing approaches that will significantly enhance the understanding of PTB. Identification of high risk women, avoidance of possible risk factors, and provision of personalized health care are important to manage PTB.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3089-0) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

et al. 2016

View full text Add to dashboard Cite

show abstract

“…1 ). The 13 studies were excluded for the following reasons: Surgical treatment in some cases and maintenance ( 28 - 35 ); surgical treatment in some cases and patients accepted to be <18 years old ( 36 , 37 ); anti microbial therapy with antibiotics ( 38 ); periodontal therapy performed by hygienist ( 39 ); not systematically healthy patients ( 39 ); sample consisted of patients with aggressive periodontitis ( 40 ). Hand searching of the selected journals did not reveal any additional publication.…”

Section: Resultsmentioning

confidence: 99%

Association of susceptible genotypes to periodontal disease with the clinical outcome and tooth survival after non-surgical periodontal therapy: A systematic review and meta-analysis

Chatzopoulos¹,

Doufexi²,

Kalogirou³

2016

Med Oral

View full text Add to dashboard Cite

BackgroundThe real clinical utility of genetic testing is the prognostic value of genetic factors in the clinical outcome of periodontal treatment and the tooth survival. A meta-analysis was undertaken to estimate the effect of a susceptible genotype to periodontitis on the clinical outcomes of non-surgical periodontal therapy and the tooth survival.Material and MethodsA systematic search of MEDLINE-Pubmed, Cochrane Library and Scopus was performed. Additionally, a hand search was done in three journals. No specific language restriction was applied. Two reviewers screened independently titles and abstracts or full text copies. Quality assessment of all the included studies was held.ResultsInitial screening of electronic databases resulted in 283 articles. Ten studies met the inclusion criteria, nine of them examined the clinical outcome, while the other one investigated the tooth survival in susceptible individuals after non-surgical periodontal therapy. Eight of included studies were selected for the meta-analysis. IL-1 positive genotypes increase the risk of tooth loss, while no association found between the bleeding on probing (BOP), clinical attachment loss (CAL) and plaque index (PI) with the genotype status. Probing pocket depth (PPD) reduction in the first three months and in long-term results found to have a significant association with the genotype.ConclusionsThere is no difference in the clinical measurements after non-surgical periodontal treatment, apart from PPD. More publications are needed to identify a cause-effect relationship. Key words:Periodontal disease, periodontitis, periodontal therapy, clinical outcome, tooth loss, susceptibility, polymorphism, genotype, meta-analysis, systematic review.

show abstract

“…Studies have shown that patients with diabetes have increased prevalence, severity and accelerated progression of periodontitis compared to those without diabetes [ 25 , 27 , 28 ]. Also, uncontrolled periodontitis negatively affects glycemic control in patients with diabetes [ 26 , 29 ], and periodontal intervention may reduce medical costs and improve health outcomes among individuals diagnosed with type 2 diabetes [ 30 , 31 ]. Designing and implementing a person-centered care model in dentistry, dental professionals are supported by a system of care that reinforces collaboration with other health care professionals in improving the overall health and well-being of person with diabetes.…”

Section: Main Textmentioning

confidence: 99%

Person-centered care model in dentistry

et al. 2018

View full text Add to dashboard Cite

BackgroundTo achieve optimal health and oral health, the system of care must place a person and their social well-being at the center of decision making and understand factors spent outside the clinical settings, including individual behavior, context and lifestyle.Main textPerson-centered care offers a unique and compelling opportunity for dentistry, and its practitioners, to improve quality of care and overall health outcomes. For decades, the dominant treatment modalities within dentistry primarily focused on a surgical, treatment-oriented approach as opposed to health promotion and improvement. However, new business and care models are disrupting the dental care system, and transforming it into one that is focused on disease management and prevention-oriented primary care that considers overall health and well-being. We proposed a person-centered care model to improve oral health as an integral part of overall health. The model identified three key players who act as change agents with their respective roles and responsibilities: Person, provider, and health care system designer.ConclusionsWhile previous person-centered models in dentistry focused on the role of providers within the clinical setting, this work emphasizes the role of the care designer in creating an environment where both person and provider are able to communicate effectively and achieve improved health outcomes.

show abstract

Association of a Common Genetic Factor, PTGER3, With Outcome of Periodontal Therapy and Preterm Birth

Abstract: These results demonstrate that the risk of unsuccessful periodontal treatment is associated with tag SNPs in specific genes that regulate the inflammatory response, one of which is also associated with sPTB.

Cited by 19 publications

References 32 publications

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

Association of susceptible genotypes to periodontal disease with the clinical outcome and tooth survival after non-surgical periodontal therapy: A systematic review and meta-analysis

Person-centered care model in dentistry

Contact Info

Product

Resources

About