Association of 5 Well-Defined Polymorphisms in the Gene Encoding Transforming Growth Factor-β1 With Coronary Artery Disease Among Chinese Patients With Hypertension

Xu, Junxia; Yu, Xiaohong; Huang, Changfu; Qin, Ruiqiang; Peng, Feng; Lin, Jinxiu; Niu, Wenquan

doi:10.1177/0003319714547946

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…TGF- β 1 is also a differentiation and growth regulator with multiple functions and plays a vital role in inflammatory response and tissue repair [ 17 ]. 5-HT is a monoamine released by platelets and mast cells after tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Efficacy on Ultrasound Combined with Neuromuscular Electrical Stimulation in Treating Lumbar Disc Herniation

Chen

Han

et al. 2022

Computational and Mathematical Methods in Medicine

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Purpose. To investigate the clinical efficacy of ultrasound (US) combined with neuromuscular electrical stimulation (NMES) in treating lumbar disc herniation (LDH) and its effect on the level of inflammatory factors. Methods. The data of 240 patients with LDH treated at our hospital from January 2020 to February 2021 were reviewed and classified into an US combined with NMES treatment group (US+NMES, n = 80 ), NMES only treatment group (NMES, n = 80 ), and US only treatment group (US, n = 80 ). Their Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) scores, levels of inflammatory factors and pain mediators, recovery rate, and total recovery time before and after treatment were compared. Additionally, the incidence of complications/adverse reactions was also investigated. Results. Compared with data before treatment, the three groups had lower VAS and ODI scores, inflammatory factor levels (interleukin- [IL-] 1, IL-6, and tumor necrosis factor- [TNF-] α), and pain mediators (transforming growth factor- [TGF-] β1, prostaglandin E2 [PEG2], and 5-hydroxytryptamine [5-HT]) after treatment, with the most significant decrease observed in the US+NMES group. Compared with patients who received US or NMES treatment alone, patients from the US+NMES had faster recovery time and lower incidence of complications/adverse reactions. Conclusion. Collectively, US combined with NMES was associated with significant relief in pain and lumbar dysfunction and reduced local inflammatory response and pain mediator levels in LDH patients, suggesting that this combined approach could achieve better efficacy than US or NMES alone.

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Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Efficacy on Ultrasound Combined with Neuromuscular Electrical Stimulation in Treating Lumbar Disc Herniation

Chen

Han

et al. 2022

Computational and Mathematical Methods in Medicine

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“…The effects of polymorphisms in genes encoding different enzymes, receptors, and growth factors on ISR or CAD are being actively investigated. Previously published reports have suggested a relationship between the occurrence of ISR or CAD and genetic variation occurring as single nucleotide polymorphisms (SNPs) in the endothelial nitric oxide synthase gene ( eNOS ) [ 11 – 13 ], the angiotensin converting enzyme gene ( ACE ) [ 14 ], the angiotensin II type 1 receptor gene ( AT1R ) [ 15 , 16 ], TGF-β [ 17 – 19 ], and VEGF [ 20 , 21 ]. However, the potential roles of functional polymorphisms in these genes in restenosis of DES have not been characterized.…”

Section: Introductionmentioning

confidence: 99%

Association of the Endothelial Nitric Oxide Synthase Gene T786C Polymorphism with In-Stent Restenosis in Chinese Han Patients with Coronary Artery Disease Treated with Drug-Eluting Stent

Zeng

Zhang

et al. 2017

PLoS ONE

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Background and aimMany studies have reported that genetic variants correlate with higher risk for coronary artery disease (CAD) or in-stent restenosis (ISR) after bare metal stent (BMS) implantation. However, there is limited data assessing the impact of these variants on ISR in patients treated with drug-eluting stent (DES). The purpose of this study was to investigate the effects of genetic risk factors on ISR in Chinese Han patients treated with DES.MethodsA total of 425 patients with a diagnosis of CAD who underwent successful revascularization in native coronary arteries with DES were included in this retrospective study. Genotyping was performed on six single nucleotide polymorphisms (SNPs) in the endothelial nitric oxide synthase gene (eNOS), the angiotensin converting enzyme gene (ACE), the angiotensin II type 1 receptor gene (AT1R), the transforming growth factor beta gene (TGF-β), and the vascular endothelial growth factor gene (VEGF). Quantitative coronary angiography (QCA) was performed during the follow-up period to detect ISR. Logistic regression models were used to test for association.ResultsFifty-four patients (12.7%) developed ISR during the follow-up period. Of the six analyzed SNPs, the frequency of the C allele of T786C polymorphism in eNOS was significantly higher in the ISR group (22.2%) compared to the non-ISR group (12.7%) (p<0.01). In the ISR group, the frequency of the TT, TC, and CC genotypes was 61.1%, 33.3%, and 5.6%, respectively, and in the non-ISR group, the frequencies were 76.8%, 21.0%, and 2.2%, respectively. The multivariable analysis adjusted for potential confounders and revealed that the T786C polymorphism increased the risk of ISR in both additive and dominant models with odds ratios of 1.870 (95% confidence interval [CI]: 1.079–3.240, p = 0.03) and 2.045 (95% CI: 1.056–3.958, p = 0.03), respectively.ConclusionThe eNOS T786C polymorphism was associated with ISR in Chinese Han patients treated with DES. Genotyping may be helpful to identify patients with higher risks of ISR after DES implantation.

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“…Regarding rs1800468 (−800G/A), CTS patients had an increased frequency of major allele G. It is controversial that minor allele A > G is associated with the occurrence of cervical cancer [ 42 ] and coronary heart disease [ 43 ]. In addition, our results showed that the minor protective A allele (GA and AA) resulted in a significant increase in serum TGF-β1 and MIP-1β levels compared with those carrying the major risk allele, G. Bogacz et al [ 44 ], reported that renal transplant patients with the A allele rs1800468 required a slightly lower dose of the immunosuppressant tacrolimus-TAC than patients with the G allele.…”

Section: Discussionmentioning

confidence: 99%

Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome

Fattah

Selim²,

Fattah

et al. 2023

JPM

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Carpal tunnel syndrome (CTS) is a common entrapment neuropathy in which one of the body’s peripheral nerves becomes pinched or crushed. Transforming growth factor beta 1 (TGF-β1) plays an important role in the pathogenesis of CTS. An association between TGF-β1 polymorphisms and the susceptibility or progression of a number of diseases has been reported. In this study, three TGF-β1 single nucleotide polymorphisms (SNPs), serum TGF-β1, and macrophage inflammatory protein 1 beta (MIP-1β) were investigated as potential diagnostic markers for the progression of CTS in Egyptian patients. One hundred CTS patients and 100 healthy controls were recruited for the study. TGF-β1 SNPs +915G/C, −509C/T and −800G/A were determined by TaqMan genotyping assay. Serum TGF-β1 and MIP-1β levels were measured by ELISA. Serum TGF-β1 and MIP-1β levels increased significantly and were strongly correlated with the occurrence of CTS. The C allele of +915G/C, the T allele of −509C/T, and the G allele of −800G/A occurred more frequently in patients from CTS than in controls. The serum levels of TGF-β1 and MIP-1β in the group of carriers of the genotypes +915G/C GC and CC, the genotype −509C/T TT and the genotype −800G/A GA and AA were significantly higher in CTS patients. TGF-β1 and its +915G/C, −509C/T, and −800G/A SNPs and MIP-1β could be useful prognostic markers for the occurrence of CTS.

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Association of 5 Well-Defined Polymorphisms in the Gene Encoding Transforming Growth Factor-β1 With Coronary Artery Disease Among Chinese Patients With Hypertension

Cited by 8 publications

References 28 publications

Clinical Evaluation of Efficacy on Ultrasound Combined with Neuromuscular Electrical Stimulation in Treating Lumbar Disc Herniation

Clinical Evaluation of Efficacy on Ultrasound Combined with Neuromuscular Electrical Stimulation in Treating Lumbar Disc Herniation

Association of the Endothelial Nitric Oxide Synthase Gene T786C Polymorphism with In-Stent Restenosis in Chinese Han Patients with Coronary Artery Disease Treated with Drug-Eluting Stent

Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome

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