Association of 25‐hydroxyvitamin <scp>D</scp> levels with liver dysfunction and mortality in chronic liver disease

Putz-Bankuti, Csilla; Pilz, Stefan; Stojaković, Tatjana; Scharnagl, Hubert; Pieber, Thomas R.; Trauner, Michael; Obermayer–Pietsch, Barbara; Stauber, Rudolf

doi:10.1111/j.1478-3231.2011.02735.x

Cited by 109 publications

(98 citation statements)

References 34 publications

(72 reference statements)

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“…These results are in agreement with other studies (17,18,19) on (8). Other studies demonstrated the lower serum vitamin D levels, the higher the degree of inflammation and/or stage of fibrosis in chronic HCV patients (15,20,21,22). Arteh et al (23) reported that vitamin D <32 ng/mL was detected in 92% of 118 patients with CLD.…”

Section: Discussionsupporting

confidence: 82%

Does Vitamin D Level Affect the Response to Antiviral Treatment in Egyptian Patients with Chronic Hepatitis C?

Hussein¹,

Mohamad²,

Mashaheet³

et al. 2017

vhd

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Section: Discussionsupporting

confidence: 82%

Does Vitamin D Level Affect the Response to Antiviral Treatment in Egyptian Patients with Chronic Hepatitis C?

Hussein¹,

Mohamad²,

Mashaheet³

et al. 2017

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“…In this single center study, we show that low vitamin D levels are common in patients with cirrhosis, as demonstrated in previous studies (6,7,9,(26)(27)(28). However, the prevalence of low vitamin levels, defined as 25(OH)D levels <20 ng/ml, was less than many previous studies (7,(26)(27)(28), which may be due to higher use of vitamin D supplementation and lower disease severity in our patient population.…”

Section: Discussionsupporting

confidence: 75%

Vitamin D Levels are Associated with Liver Disease Severity in Patients with Cirrhosis

Rech

Roenn

Durazo‐Arvizu

et al. 2017

jrenhep

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Vitamin D deficiency is common in advanced liver disease but its clinical significance remains controversial. The aim of this study was to examine the correlation of 25-hydryoxyvitamin D levels with liver disease severity and calcium levels in adults with cirrhosis. This cross-sectional study included 180 adults with cirrhosis enrolled in a clinical cohort study at a single university hospital. The mean age was 58.8 (±9.2) years, and cirrhosis was attributed to alcohol use in 27.2%, hepatitis C in 35.0%, non-alcoholic steatohepatitis in 27.2%, and both alcohol and hepatitis C in 10.6%. The median model for end-stage liver disease-sodium (MELD-Na) score was 12.0 (interquartile range 9.0-16.0), and mean serum albumin levels were 3.4 (±0.7) gm/dl. Median serum 25-hydroxyvitamin D levels were 28.0 (interquartile range 20-38) ng/mL, with 16 patients (8.9%) having levels <12 ng/ml and 43 (23.9%) with 25(OH)D levels <20 ng/ml. No correlation was noted between levels of 25-hydroxyvitamin D and albumincorrected calcium in the total group and in groups stratified by vitamin D supplementation. In contrast, both serum albumin (r = 0.32; P < 0.001) and MELD-Na scores were significantly correlated with 25-hydroxyvitamin D levels (r = -0.29; P < 0.001). Correlations between 25-hydroxyvitamin D levels and serum albumin (r = −0.39; P < 0.001) and MELD-Na scores did not change substantially after excluding 67 patients receiving vitamin D supplementation (r = −0.33; P = 0.009). In conclusion, total 25-hydroxyvitamin D levels correlate inversely with liver disease severity in adults with cirrhosis.

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“…This is because of most of cases in our study belonged , Putz-Bankuti C et al 19 and Finkelmeier F et al 22 We also found low vitamin D level was associated with poor outcome similar to Finkelmeier F et al 22 Thus our results suggest that vitamin D might be both a biomarker of severity and a potential therapeutic target in CLD.…”

Section: Discussionsupporting

confidence: 69%

“…We found low prevalence of CLD in Females in contrast to earlier study done by Putz Bankuti C et al, 19 which consists of 51 males (68%) and 24 females (32%) with a mean age of 58 ± 11 years (range: 25-89 years).…”

Section: Discussioncontrasting

confidence: 55%

Evaluation Of Vitamin D Deficiency In Patients With Chronic Liver Disease And Its Clinical Significance

Gupta

Saini

Nehara

et al. 2016

IJN

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Association of 25‐hydroxyvitamin D levels with liver dysfunction and mortality in chronic liver disease

Abstract: Our findings show a significant association of 25(OH)D with the degree of liver dysfunction and suggest that low 25(OH)D levels may predict hepatic decompensation and mortality in patients with chronic liver failure.

Cited by 109 publications

References 34 publications

Does Vitamin D Level Affect the Response to Antiviral Treatment in Egyptian Patients with Chronic Hepatitis C?

Does Vitamin D Level Affect the Response to Antiviral Treatment in Egyptian Patients with Chronic Hepatitis C?

Vitamin D Levels are Associated with Liver Disease Severity in Patients with Cirrhosis

Evaluation Of Vitamin D Deficiency In Patients With Chronic Liver Disease And Its Clinical Significance

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