Association of 2238T&gt;C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes

Larifla, Laurent; Maimaitiming, Suriya; Vélayoudom-Céphise, Fritz-Line; Ferdinand, Séverine; Blanchet-Deverly, Anne; Benabdallah, S; Donnet, J.-P.; Atallah, A.; Roussel, Ronan; Foucan, Lydia

doi:10.1038/ajh.2011.233

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…Some researchers found that the minor allele G was associated with higher risk of acute coronary syndrome [11] and greater severities of CAD [12], while other studies reported that the major allele A was more prevalent in CAD patients [13] and was associated with a higher risk of hypertension, more adverse ventricular remodeling and a higher rate of hospital readmission [7]. The discrepancy could be explained by diverse patient populations and different outcomes defining CAD.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis

Tse

Pang

et al. 2017

Cardiol Res

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BackgroundPolymorphisms within natriuretic peptide (NP) genes have been associated with clinical outcomes for cardiovascular disease (CVD), but no previous study has compared the effect of these polymorphisms between men and women. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in key genes of the NP system and coronary angiographic outcomes, with the focus on the sexual dimorphism in the effects of these SNPs.MethodsPatients undergoing clinically indicated coronary angiography (n = 513, 328 men and 185 women) were consented and genotyped for NPPA rs5065, NPPB rs198389 and NPR2 rs10758325. Patients were stratified into having normal coronaries, non-obstructive coronary artery disease (CAD) or obstructive CAD, based on the highest stenosis in any epicardial artery. Average luminal narrowing across all four arteries was derived to represent the overall atherosclerotic burden.ResultsThe frequency of NPPB rs198389 AA genotype was significantly higher in women with obstructive CAD (P = 0.014). The same association was not observed in males. With respect to atherosclerotic burden, an association was found between the AA genotype and average luminal narrowing in women (P = 0.005), but not in men.ConclusionsThe current study identified an association between an SNP of the NPPB gene and coronary atherosclerotic burden through angiographic evidence in women but not in men. These results suggest that B-type natriuretic peptide (BNP) may have more important involvement in the development of CAD in women compared to men, and as such, genotyping of the NPPB gene may serve as a potential biomarker to identify women with high risk for CAD.

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Section: Discussionmentioning

confidence: 99%

Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis

Tse

Pang

et al. 2017

Cardiol Res

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“…These variables have already been used in the previous similar studies. [35][36][37][38] Statistically analysis was performed with SPSS software version 19. There are many methods which deals with probabilities of disturbance.…”

Section: Methodsmentioning

confidence: 99%

Effects of Diabetes on The Output of Farmer and Its Policy Implications

Naqvi

Hussain

Shah

et al. 2020

Kesmas: National Public Health Journal

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This study investigated the impact of diabetes on work performance of different farming communities from Punjab, Pakistan. This study was based on cross-sectional data. A representative sample of 374 farmers was collected from five selected districts. Three types of respondents were analyzed in the study e.g.,laborer, small and large growers. Poisson and logistic regression techniques were used for the sake of analysis. According to the investigated results for thelabor category, respondents with more age, less qualification, low earning per month (Rupees), and having positive record of family diabetes, would havemore leave per month. In the same way, findings for small farmers revealed that education, family size, family with diabetic records, marital status and availability at farm (hour/day) were significant. In case of third category, study outcome highlighted that age, education, marital status, having positive record offamily diabetes and number of hours spent at farm would be positively correlated with the reduction in working efficiency at farm due to diabetes. It can beconcluded that diabetes have negative influence on the work performance of selected farming groups.

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“…These polymorphisms were chosen because of different data from the literature: significant associations between rs1799883 and MetS [ 14 ], association of rs1501299 with the concomitant presence of MetS and hypertension in a Taiwanese population [ 15 ], and association of rs5065 with diabetic complications and cardiovascular disease [ 12 , 13 ]. In addition, previous studies in relation with cardiometabolic risk were conducted for rs1501299 and rs5065 in our Afro-Caribbean diabetic population with and without history of CAD [ 16 , 17 ], and in descendants of Indian migrants living in Guadeloupe for rs1799883 [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Gene Polymorphisms of FABP2, ADIPOQ and ANP and Risk of Hypertriglyceridemia and Metabolic Syndrome in Afro-Caribbeans

et al. 2016

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ObjectivesThe metabolic syndrome (MetS) is a cluster of metabolic abnormalities and cardiovascular risk factors that are highly heritable and polygenic. We investigated the association of allelic variants of three candidate genes, rs1799883-FABP2, rs1501299-ADIPOQ and rs5065-ANP with MetS and its components, individually and in combination, using a genetic risk score.MethodsA cross-sectional study was conducted in 462 Afro-Caribbeans subjects without cardiovascular complications or lipid-lowering medications. Cardiovascular risk factors and MetS components (NCEP-ATPIII criteria) were recorded. The 3 SNPs were genotyped. The genetic risk score was calculated by summing the number of risk alleles at each locus. Logistic regressions were used.ResultsFifty-eight participants (12.6%) were diabetics and 116 (25.1%) had a MetS. In a dominant model, rs1799883 was associated with hypertriglyceridemia (OR 2.22; P = 0.014) and hypertriglyceridemic waist (HTGW), (P = 0.014) but not significantly with overweight (P = 0.049), abdominal obesity (P = 0.033) and MetS (P = 0.068). In a dominant model, the OR of MetS and HTGW for rs1501299 were 1.80 (P = 0.028) and 2.19 (P = 0.040) respectively. In a recessive model, the OR of hypertriglyceridemia for rs5065 was 1.94 (P = 0.075). The genetic risk score was significantly associated with MetS. Subjects carrying 4–5 risk alleles (18.8%) had a nearly 2.5-fold-increased risk of MetS compared to those carrying 0–1 risk allele (24.3%): OR 2.31; P = 0.025.ConclusionsThis study supports the association of FABP2, ANP and ADIPOQ gene variants with MetS or its components in Afro-Caribbeans and suggests a cumulative genetic influence of theses variants on this syndrome and a potential effect on lipid metabolism.

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Association of 2238T>C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes

Abstract: The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent. The relevance of ANP polymorphisms for CAD should be determined in different populations.

Cited by 9 publications

References 14 publications

Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis

Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis

Effects of Diabetes on The Output of Farmer and Its Policy Implications

Gene Polymorphisms of FABP2, ADIPOQ and ANP and Risk of Hypertriglyceridemia and Metabolic Syndrome in Afro-Caribbeans

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